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All KERs

Showing 301 to 325 of 3158 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

649	633: Decrease, histaminergic neuron excitation	634: N/A, sedation	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
650	634: N/A, sedation	635: Decreased, locomotion	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
651	635: Decreased, locomotion	588: Increased, predation	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
654	588: Increased, predation	636: Decreased, survival	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
656	385: Synaptogenesis, Decreased	188: Neuroinflammation	Nov 29, 2016	Dec 3, 2016	None
659	663: Desensitization, Nicotinic acetylcholine receptor	386: Neuronal network function, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
660	177: Increase, Mitochondrial dysfunction	664: Overwhelmed, Mitochondrial DNA repair mechanisms	Nov 29, 2016	Dec 3, 2016	1 AOP 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
661	664: Overwhelmed, Mitochondrial DNA repair mechanisms	570: Accumulation, Damaged mitochondrial DNA	Nov 29, 2016	Dec 3, 2016	1 AOP 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
662	570: Accumulation, Damaged mitochondrial DNA	571: Accelerated, Aging	Nov 29, 2016	Dec 3, 2016	1 AOP 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
663	571: Accelerated, Aging	572: Decrease, Number of worker bees	Nov 29, 2016	Dec 3, 2016	1 AOP 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
664	177: Increase, Mitochondrial dysfunction	583: impaired, Thoracic shivering	Nov 29, 2016	Dec 3, 2016	None
665	583: impaired, Thoracic shivering	568: impaired, Hive thermoregulation	Nov 29, 2016	Dec 3, 2016	None
670	79: Inhibition, Cyclooxygenase activity	672: Reduced, Prostaglandin F2alpha synthesis, ovary	Nov 29, 2016	Dec 3, 2016	1 AOP 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
671	672: Reduced, Prostaglandin F2alpha synthesis, ovary	671: Reduced, Prostaglandin F2alpha concentration, plasma	Nov 29, 2016	Dec 3, 2016	1 AOP 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
672	671: Reduced, Prostaglandin F2alpha concentration, plasma	673: Reduced, Spawning behavior	Nov 29, 2016	Dec 3, 2016	1 AOP 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
673	673: Reduced, Spawning behavior	674: Reduced, Ability to attract spawning mates	Nov 29, 2016	Dec 3, 2016	1 AOP 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
674	674: Reduced, Ability to attract spawning mates	675: Reduced, Reproductive Success	Nov 29, 2016	Dec 3, 2016	2 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
675	675: Reduced, Reproductive Success	360: Decrease, Population growth rate	Nov 29, 2016	Dec 3, 2016	5 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 63: Cyclooxygenase inhibition leading to reproductive dysfunction 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
678	671: Reduced, Prostaglandin F2alpha concentration, plasma	678: Reduced, Pheromone release	Nov 29, 2016	Dec 3, 2016	1 AOP 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
679	678: Reduced, Pheromone release	674: Reduced, Ability to attract spawning mates	Nov 29, 2016	Dec 3, 2016	1 AOP 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
681	79: Inhibition, Cyclooxygenase activity	681: Decreased, Prostaglandin F2alpha synthesis, ovary	Nov 29, 2016	Dec 3, 2016	1 AOP 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
682	681: Decreased, Prostaglandin F2alpha synthesis, ovary	671: Reduced, Prostaglandin F2alpha concentration, plasma	Nov 29, 2016	Dec 3, 2016	1 AOP 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
685	685: Reduced, Prostaglandins, ovary	488: Decrease, Ovulation	Nov 29, 2016	Dec 3, 2016	1 AOP 63: Cyclooxygenase inhibition leading to reproductive dysfunction
686	79: Inhibition, Cyclooxygenase activity	685: Reduced, Prostaglandins, ovary	Nov 29, 2016	Dec 3, 2016	1 AOP 63: Cyclooxygenase inhibition leading to reproductive dysfunction
687	488: Decrease, Ovulation	675: Reduced, Reproductive Success	Nov 29, 2016	Dec 3, 2016	1 AOP 63: Cyclooxygenase inhibition leading to reproductive dysfunction

Key Event Relationships (KERs)

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