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All KERs

Showing 26 to 50 of 3131 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

82	68: Increase, Collagen accumulation	344: Increase, Liver fibrosis	Nov 29, 2016	Dec 5, 2018	8 AOPs 38: Protein Alkylation leading to Liver Fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
88	75: N/A, Covalent binding to protein, possibly lysine residue	151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways	Nov 29, 2016	Sep 24, 2020	None
93	77: Production, Critical Metabolites (CGA 330050 and CGA 265307)	164: Induction, Liver “Dysfunctional” Changes by CGA 330050	Nov 29, 2016	Dec 3, 2016	1 AOP 32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
94	78: Reduction, Cumulative fecundity and spawning	360: Decrease, Population growth rate	Nov 29, 2016	Mar 20, 2017	12 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
95	79: Inhibition, Cyclooxygenase activity	243: Reduction, Prostaglandin E2 concentration	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure
96	80: Up Regulation, CYP1A1	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
104	84: Up Regulation, CYP1B1	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Nov 29, 2016	Dec 3, 2016	None
108	87: Release, Cytokine	149: Increase, Inflammation	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
110	89: Synthesis, De Novo Fatty Acid (FA)	291: Accumulation, Triglyceride	Nov 29, 2016	Mar 29, 2024	2 AOPs 34: LXR activation leading to hepatic steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis
116	103: Increase, EcR hyperactivation	60: Induction, Chitin degradation and resorption	Nov 29, 2016	Dec 3, 2016	None
123	106: Reduction, Eggshell thickness	253: N/A, Reproductive failure	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure
125	110: Impairment, Endothelial network	298: Insufficiency, Vascular	Nov 29, 2016	Jan 18, 2022	1 AOP 43: Disruption of VEGFR Signaling Leading to Developmental Defects
126	111: Agonism, Estrogen receptor	363: Altered, Reproductive behaviour	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
127	111: Agonism, Estrogen receptor	364: Impaired development of, Reproductive organs	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
128	111: Agonism, Estrogen receptor	307: Increase, Vitellogenin synthesis in liver	Nov 29, 2016	Jun 24, 2024	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
129	112: Antagonism, Estrogen receptor	285: Reduction, Vitellogenin synthesis in liver	Nov 29, 2016	Nov 30, 2016	1 AOP 30: Estrogen receptor antagonism leading to reproductive dysfunction
132	115: Increase, FA influx	291: Accumulation, Triglyceride	Nov 29, 2016	Mar 29, 2024	2 AOPs 34: LXR activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis
133	116: Activation, FAS	89: Synthesis, De Novo Fatty Acid (FA)	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis
135	328: Decrease, Fecundity	361: Decline, Population	Nov 29, 2016	Dec 3, 2016	None
136	119: N/A, Gap	49: Reduction, Ca and HCO3 transport to shell gland	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure
143	129: Reduction, Gonadotropins, circulating concentrations	274: Reduction, Testosterone synthesis by ovarian theca cells	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
146	134: Increase, Kupffer cell activation	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
147	134: Increase, Kupffer cell activation	276: Up Regulation, TGFbeta1 expression	Nov 29, 2016	Nov 29, 2016	None
154	140: Decreased, HSD17B10 expression	8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
158	142: Hyperplasia, Hyperplasia	334: Promotion, Hepatocelluar carcinoma	Nov 29, 2016	Dec 3, 2016	1 AOP 1: Uncharacterized liver damage leading to hepatocellular carcinoma

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