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Showing 51 to 75 of 3130 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3387 2275: Co-localization of gluten reactive adaptive T-cells with APC 2252: Formation of HLA-DQ2/8-gluten complexes Nov 12, 2024 Nov 12, 2024 None
3623 495: Repressed expression of steroidogenic enzymes 3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Sep 3, 2025 Sep 3, 2025 None
3609 1560: Cell differentiation, altered 772: Increase, Hyperplasia (glandular epithelial cells of endometrium) Aug 26, 2025 Aug 29, 2025 None
3638 2258: Inhibition, monocarboxylate transporter 8 (MCT8) 280: T4 in neuronal tissue, Decreased Sep 29, 2025 Sep 29, 2025 None
3482 18: Activation, AhR 1883: Decreased, ovarian reserve Jan 22, 2025 Jan 22, 2025 None
3492 1115: Increase, ROS 1446: Decrease, Coupling of OXPHOS Feb 25, 2025 Feb 25, 2025 None
3330 2254: Generation of gluten-reactive and TG2-reactive B cell receptors 272: Activation/Proliferation, T-cells Aug 13, 2024 Aug 13, 2024 None
3339 2253: Generation of gluten-reactive T cell receptors 2260: Activation of gluten-reactive CD4+ T cells Sep 13, 2024 Sep 13, 2024 None
3338 2252: Formation of HLA-DQ2/8-gluten complexes 2260: Activation of gluten-reactive CD4+ T cells Sep 13, 2024 Sep 13, 2024 None
3337 272: Activation/Proliferation, T-cells 2252: Formation of HLA-DQ2/8-gluten complexes Aug 13, 2024 Aug 13, 2024 None
3336 2256: Activation of gluten- and TG2-reactive B cells 272: Activation/Proliferation, T-cells Aug 13, 2024 Aug 13, 2024 None
3340 2254: Generation of gluten-reactive and TG2-reactive B cell receptors 2260: Activation of gluten-reactive CD4+ T cells Sep 13, 2024 Sep 13, 2024 None
3334 272: Activation/Proliferation, T-cells 1931: Disruption of the intestinal barrier Aug 13, 2024 Aug 13, 2024 None
3332 272: Activation/Proliferation, T-cells 2256: Activation of gluten- and TG2-reactive B cells Aug 13, 2024 Aug 13, 2024 None
3331 2255: Activation of the innate immune response 272: Activation/Proliferation, T-cells Aug 13, 2024 Aug 13, 2024 None
3329 2253: Generation of gluten-reactive T cell receptors 272: Activation/Proliferation, T-cells Aug 13, 2024 Aug 13, 2024 None
3328 2252: Formation of HLA-DQ2/8-gluten complexes 272: Activation/Proliferation, T-cells Aug 13, 2024 Aug 13, 2024 None
3343 2260: Activation of gluten-reactive CD4+ T cells 1931: Disruption of the intestinal barrier Sep 13, 2024 Sep 13, 2024 None
3344 2260: Activation of gluten-reactive CD4+ T cells 2252: Formation of HLA-DQ2/8-gluten complexes Sep 13, 2024 Sep 13, 2024 None
3345 2256: Activation of gluten- and TG2-reactive B cells 2260: Activation of gluten-reactive CD4+ T cells Sep 13, 2024 Sep 13, 2024 None
3422 2286: Na⁺/K⁺-ATPase 1535: Heart failure Nov 21, 2024 Nov 21, 2024 None
3423 2286: Na⁺/K⁺-ATPase 1321: Increased, intracellular sodium (Na+) Nov 21, 2024 Nov 21, 2024 None
3427 2288: Phosphodiesterase (PDE) 2284: Intracellular cAMP Nov 22, 2024 Nov 22, 2024 None
3428 2284: Intracellular cAMP 2289: RyR2 hyperphosphorylation Nov 22, 2024 Nov 22, 2024 None
3409 2281: uncoordinated cardiac contraction 1929: Increased incidence of cardiovascular morbidity and mortality Nov 20, 2024 Nov 20, 2024 None