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All KERs

Showing 51 to 75 of 3131 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

5	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	219: Reduction, Plasma 17beta-estradiol concentrations	Nov 29, 2016	Mar 20, 2017	6 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
36	28: Reduction, Angiogenesis	110: Impairment, Endothelial network	Nov 29, 2016	Jan 18, 2022	1 AOP 43: Disruption of VEGFR Signaling Leading to Developmental Defects
32	25: Agonism, Androgen receptor	274: Reduction, Testosterone synthesis by ovarian theca cells	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
31	25: Agonism, Androgen receptor	129: Reduction, Gonadotropins, circulating concentrations	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
25	97: Alkylation, DNA	185: Increase, Mutations	Nov 29, 2016	Nov 29, 2016	2 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 139: Alkylation of DNA leading to cancer 1
24	97: Alkylation, DNA	155: Inadequate DNA repair	Nov 29, 2016	Dec 10, 2019	3 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 139: Alkylation of DNA leading to cancer 1 322: Alkylation of DNA leading to reduced sperm count
23	97: Alkylation, DNA	336: Increase, Heritable mutations in offspring	Nov 29, 2016	Nov 29, 2016	1 AOP 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
19	18: Activation, AhR	80: Up Regulation, CYP1A1	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
18	18: Activation, AhR	17: Altered expression of AHR/ARNT pathway-dependent genes	Nov 29, 2016	Dec 3, 2016	None
17	17: Altered expression of AHR/ARNT pathway-dependent genes	80: Up Regulation, CYP1A1	Nov 29, 2016	Dec 3, 2016	None
16	17: Altered expression of AHR/ARNT pathway-dependent genes	317: Altered, Cardiovascular development/function	Nov 29, 2016	Dec 3, 2016	None
11	12: AchE Inhibition	10: ACh Synaptic Accumulation	Nov 29, 2016	Sep 10, 2023	4 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
9	8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity	179: Decrease, Fatty acid β-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
198	350: Increase, Mortality	328: Decrease, Fecundity	Nov 29, 2016	Dec 3, 2016	None
169	161: Increase, Liver and splenic hemosiderosis	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
170	164: Induction, Liver “Dysfunctional” Changes by CGA 330050	147: Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307	Nov 29, 2016	Dec 3, 2016	1 AOP 32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
172	165: Activation, Long term AHR receptor driven direct and indirect gene expression changes	139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects	Nov 29, 2016	Nov 29, 2016	1 AOP 41: Sustained AhR Activation leading to Rodent Liver Tumours
173	167: Activation, LXR	54: Up Regulation, CD36	Nov 29, 2016	Dec 3, 2016	2 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis
174	167: Activation, LXR	66: Activation, ChREBP	Nov 29, 2016	Dec 3, 2016	2 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis
175	167: Activation, LXR	116: Activation, FAS	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis
176	167: Activation, LXR	258: Activation, SCD-1	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis
177	167: Activation, LXR	264: Activation, SREBP-1c	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis
182	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	321: N/A, Cyanosis occurs	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
188	178: Mitochondrial electron transport chain, disrupted	40: Mitochondrial ATP production, decreased	Nov 29, 2016	Dec 3, 2016	3 AOPs 26: Calcium-mediated neuronal ROS production and energy imbalance 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
190	179: Decrease, Fatty acid β-oxidation	327: Accumulation, Fatty acid	Nov 29, 2016	Dec 3, 2016	2 AOPs 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis

Key Event Relationships (KERs)

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