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All KERs

Showing 51 to 75 of 3131 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

159	147: Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307	270: Induction, Sustained Hepatotoxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
164	155: Inadequate DNA repair	185: Increase, Mutations	Nov 29, 2016	Mar 8, 2024	8 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 141: Alkylation of DNA leading to cancer 2 139: Alkylation of DNA leading to cancer 1 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 397: Bulky DNA adducts leading to mutations 443: DNA damage and mutations leading to Metastatic Breast Cancer 478: Deposition of energy leading to occurrence of cataracts
168	158: N/A, Interferences with SH-/selen-proteins	130: Depletion, GSH	Nov 29, 2016	Dec 3, 2016	None
169	161: Increase, Liver and splenic hemosiderosis	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
170	164: Induction, Liver “Dysfunctional” Changes by CGA 330050	147: Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307	Nov 29, 2016	Dec 3, 2016	1 AOP 32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
172	165: Activation, Long term AHR receptor driven direct and indirect gene expression changes	139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects	Nov 29, 2016	Nov 29, 2016	1 AOP 41: Sustained AhR Activation leading to Rodent Liver Tumours
173	167: Activation, LXR	54: Up Regulation, CD36	Nov 29, 2016	Dec 3, 2016	2 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis
174	167: Activation, LXR	66: Activation, ChREBP	Nov 29, 2016	Dec 3, 2016	2 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis
175	167: Activation, LXR	116: Activation, FAS	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis
176	167: Activation, LXR	258: Activation, SCD-1	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis
177	167: Activation, LXR	264: Activation, SREBP-1c	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis
182	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	321: N/A, Cyanosis occurs	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
188	178: Mitochondrial electron transport chain, disrupted	40: Mitochondrial ATP production, decreased	Nov 29, 2016	Dec 3, 2016	3 AOPs 26: Calcium-mediated neuronal ROS production and energy imbalance 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
190	179: Decrease, Fatty acid β-oxidation	327: Accumulation, Fatty acid	Nov 29, 2016	Dec 3, 2016	2 AOPs 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
196	183: Abnormal, Morphogenesis	342: Increased, Lethality	Nov 29, 2016	Dec 3, 2016	None
197	183: Abnormal, Morphogenesis	366: Increased, Structural malformations	Nov 29, 2016	Dec 3, 2016	None
198	350: Increase, Mortality	328: Decrease, Fecundity	Nov 29, 2016	Dec 3, 2016	None
199	350: Increase, Mortality	361: Decline, Population	Nov 29, 2016	Dec 3, 2016	None
200	351: Increased Mortality	361: Decline, Population	Nov 29, 2016	Dec 3, 2016	None
202	185: Increase, Mutations	336: Increase, Heritable mutations in offspring	Nov 29, 2016	Nov 29, 2016	1 AOP 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
203	186: Altered, Neuroanatomy	192: Altered, Neurophysiology	Nov 29, 2016	Nov 29, 2016	1 AOP 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
207	352: N/A, Neurodegeneration	188: Neuroinflammation	Nov 29, 2016	Jun 13, 2018	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
208	188: Neuroinflammation	352: N/A, Neurodegeneration	Nov 29, 2016	Feb 23, 2021	4 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 471: Neuron defect induced early behavioral change
210	191: Neuronal dysfunction	188: Neuroinflammation	Nov 29, 2016	Nov 29, 2016	None
212	193: Decreased, Nitric Oxide	166: Decreased, Long-term potentiation (LTP)	Nov 29, 2016	Dec 3, 2016	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance

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