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All KERs

Showing 76 to 100 of 3131 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

196	183: Abnormal, Morphogenesis	342: Increased, Lethality	Nov 29, 2016	Dec 3, 2016	None
197	183: Abnormal, Morphogenesis	366: Increased, Structural malformations	Nov 29, 2016	Dec 3, 2016	None
168	158: N/A, Interferences with SH-/selen-proteins	130: Depletion, GSH	Nov 29, 2016	Dec 3, 2016	None
199	350: Increase, Mortality	361: Decline, Population	Nov 29, 2016	Dec 3, 2016	None
200	351: Increased Mortality	361: Decline, Population	Nov 29, 2016	Dec 3, 2016	None
202	185: Increase, Mutations	336: Increase, Heritable mutations in offspring	Nov 29, 2016	Nov 29, 2016	1 AOP 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
203	186: Altered, Neuroanatomy	192: Altered, Neurophysiology	Nov 29, 2016	Nov 29, 2016	1 AOP 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
207	352: N/A, Neurodegeneration	188: Neuroinflammation	Nov 29, 2016	Jun 13, 2018	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
208	188: Neuroinflammation	352: N/A, Neurodegeneration	Nov 29, 2016	Feb 23, 2021	4 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 471: Neuron defect induced early behavioral change
210	191: Neuronal dysfunction	188: Neuroinflammation	Nov 29, 2016	Nov 29, 2016	None
212	193: Decreased, Nitric Oxide	166: Decreased, Long-term potentiation (LTP)	Nov 29, 2016	Dec 3, 2016	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance
213	195: Inhibition, NMDARs	52: Decreased, Calcium influx	Nov 29, 2016	Apr 7, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
214	195: Inhibition, NMDARs	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	None
215	195: Inhibition, NMDARs	191: Neuronal dysfunction	Nov 29, 2016	Dec 3, 2016	None
228	201: Binding of antagonist, NMDA receptors	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	None
128	111: Agonism, Estrogen receptor	307: Increase, Vitellogenin synthesis in liver	Nov 29, 2016	Jun 24, 2024	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
93	77: Production, Critical Metabolites (CGA 330050 and CGA 265307)	164: Induction, Liver “Dysfunctional” Changes by CGA 330050	Nov 29, 2016	Dec 3, 2016	1 AOP 32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
94	78: Reduction, Cumulative fecundity and spawning	360: Decrease, Population growth rate	Nov 29, 2016	Mar 20, 2017	12 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
95	79: Inhibition, Cyclooxygenase activity	243: Reduction, Prostaglandin E2 concentration	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure
96	80: Up Regulation, CYP1A1	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
104	84: Up Regulation, CYP1B1	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Nov 29, 2016	Dec 3, 2016	None
108	87: Release, Cytokine	149: Increase, Inflammation	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
110	89: Synthesis, De Novo Fatty Acid (FA)	291: Accumulation, Triglyceride	Nov 29, 2016	Mar 29, 2024	2 AOPs 34: LXR activation leading to hepatic steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis
116	103: Increase, EcR hyperactivation	60: Induction, Chitin degradation and resorption	Nov 29, 2016	Dec 3, 2016	None
123	106: Reduction, Eggshell thickness	253: N/A, Reproductive failure	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure

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