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All KERs

Showing 76 to 100 of 3131 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

213	195: Inhibition, NMDARs	52: Decreased, Calcium influx	Nov 29, 2016	Apr 7, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
214	195: Inhibition, NMDARs	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	None
215	195: Inhibition, NMDARs	191: Neuronal dysfunction	Nov 29, 2016	Dec 3, 2016	None
228	201: Binding of antagonist, NMDA receptors	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	None
229	201: Binding of antagonist, NMDA receptors	195: Inhibition, NMDARs	Nov 29, 2016	Jun 13, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
236	209: Peptide Oxidation	134: Increase, Kupffer cell activation	Nov 29, 2016	Dec 3, 2016	None
242	213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin	21: Altered regulation, Alpha hemoglobin	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
243	213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin	118: Formation, Formation of hemoglobin adducts	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
245	213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin	250: Damaging, Red blood cells; hemolysis	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
248	214: Bile accumulation, Pathological condition	288: Activation of specific nuclear receptors, Transcriptional change	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
252	219: Reduction, Plasma 17beta-estradiol concentrations	285: Reduction, Vitellogenin synthesis in liver	Nov 29, 2016	Mar 20, 2017	5 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
253	219: Reduction, Plasma 17beta-estradiol concentrations	309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development	Nov 29, 2016	Nov 29, 2016	None
254	220: Increase, Plasma vitellogenin concentrations	252: Increase, Renal pathology due to VTG deposition	Nov 29, 2016	Jun 24, 2024	2 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
255	221: Reduction, Plasma vitellogenin concentrations	309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development	Nov 29, 2016	Mar 20, 2017	9 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 25: Aromatase inhibition leading to reproductive dysfunction 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
257	231: Decreased, PPAR-alpha activation	140: Decreased, HSD17B10 expression	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
259	232: Decreased, PPAR-beta activation	140: Decreased, HSD17B10 expression	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
260	233: Decreased, PPAR-gamma activation	140: Decreased, HSD17B10 expression	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
261	238: Induction, Pre-mature molting	328: Decrease, Fecundity	Nov 29, 2016	Dec 3, 2016	None
262	238: Induction, Pre-mature molting	350: Increase, Mortality	Nov 29, 2016	Dec 3, 2016	None
263	238: Induction, Pre-mature molting	351: Increased Mortality	Nov 29, 2016	Dec 3, 2016	None
266	240: Feminisation or incomplete development, Primary and accessory male sex organs	337: N/A, Impairment of reproductive capacity	Nov 29, 2016	Dec 3, 2016	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
268	243: Reduction, Prostaglandin E2 concentration	119: N/A, Gap	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure
269	244: Alkylation, Protein	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	1 AOP 38: Protein Alkylation leading to Liver Fibrosis
271	244: Alkylation, Protein	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
272	246: Increase, RBC congestion in liver	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity

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