Key Event Relationships (KERs)

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Showing 176 to 200 of 3130 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
70 60: Induction, Chitin degradation and resorption 238: Induction, Pre-mature molting Nov 29, 2016 Dec 3, 2016 None
16 17: Altered expression of AHR/ARNT pathway-dependent genes 317: Altered, Cardiovascular development/function Nov 29, 2016 Dec 3, 2016 None
17 17: Altered expression of AHR/ARNT pathway-dependent genes 80: Up Regulation, CYP1A1 Nov 29, 2016 Dec 3, 2016 None
18 18: Activation, AhR 17: Altered expression of AHR/ARNT pathway-dependent genes Nov 29, 2016 Dec 3, 2016 None
62 52: Decreased, Calcium influx 341: Impairment, Learning and memory Nov 29, 2016 Dec 3, 2016 None
51 39: Increased Cholinergic Signaling 360: Decrease, Population growth rate Nov 29, 2016 Dec 3, 2016 None
261 238: Induction, Pre-mature molting 328: Decrease, Fecundity Nov 29, 2016 Dec 3, 2016 None
287 261: Binding, SH-/selen-proteins 158: N/A, Interferences with SH-/selen-proteins Nov 29, 2016 Dec 3, 2016 None
296 366: Increased, Structural malformations 342: Increased, Lethality Nov 29, 2016 Dec 3, 2016 None
301 272: Activation/Proliferation, T-cells 312: N/A, Allergic contact dermatitis on challenge Nov 29, 2016 Dec 3, 2016 None
271 244: Alkylation, Protein 209: Peptide Oxidation Nov 29, 2016 Dec 3, 2016 None
303 276: Up Regulation, TGFbeta1 expression 68: Increase, Collagen accumulation Nov 29, 2016 Dec 3, 2016 None
304 276: Up Regulation, TGFbeta1 expression 265: Increase, HSC activation Nov 29, 2016 Nov 29, 2016 None
263 238: Induction, Pre-mature molting 351: Increased Mortality Nov 29, 2016 Dec 3, 2016 None
262 238: Induction, Pre-mature molting 350: Increase, Mortality Nov 29, 2016 Dec 3, 2016 None
331 301: Binding, VEGF-A 305: Inhibition, VegfR2 Nov 29, 2016 Dec 3, 2016 None
236 209: Peptide Oxidation 134: Increase, Kupffer cell activation Nov 29, 2016 Dec 3, 2016 None
334 304: Decreased, VegfR2 305: Inhibition, VegfR2 Nov 29, 2016 Dec 3, 2016 None
333 302: Production, VEGF-A 304: Decreased, VegfR2 Nov 29, 2016 Dec 3, 2016 None
332 302: Production, VEGF-A 301: Binding, VEGF-A Nov 29, 2016 Dec 3, 2016 None
330 301: Binding, VEGF-A 304: Decreased, VegfR2 Nov 29, 2016 Dec 3, 2016 None
253 219: Reduction, Plasma 17beta-estradiol concentrations 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Nov 29, 2016 Nov 29, 2016 None
329 298: Insufficiency, Vascular 183: Abnormal, Morphogenesis Nov 29, 2016 Dec 3, 2016 None
368 352: N/A, Neurodegeneration 386: Neuronal network function, Decreased Nov 29, 2016 Dec 3, 2016 None
399 289: Decrease, Translocator protein (TSPO) 413: Reduction, Testosterone synthesis in Leydig cells Nov 29, 2016 Dec 3, 2016 None