Key Event Relationships (KERs)

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Showing 176 to 200 of 3131 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
393 405: disrupted, ovarian cycle 330: Decrease, Fertility Nov 29, 2016 Dec 3, 2016 None
394 405: disrupted, ovarian cycle 406: decreased, Fertility Nov 29, 2016 Mar 18, 2025
395 228: demethylation, PPARg promoter 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Nov 29, 2016 Dec 3, 2016 None
396 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) 3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Nov 29, 2016 Nov 29, 2016
398 416: Increase proliferation, Leydig cell 415: Hyperplasia, Leydig cell Nov 29, 2016 Dec 3, 2016
399 289: Decrease, Translocator protein (TSPO) 413: Reduction, Testosterone synthesis in Leydig cells Nov 29, 2016 Dec 3, 2016 None
402 409: Metabolism of AFB1, Production of Reactive Electrophiles 373: Formation, Pro-mutagenic DNA Adducts Nov 29, 2016 Nov 29, 2016
403 281: T4 in serum, Decreased 402: Cognitive function, decreased Nov 29, 2016 Apr 27, 2026
405 348: Malformation, Male reproductive tract 406: decreased, Fertility Nov 29, 2016 Dec 2, 2016
411 228: demethylation, PPARg promoter 54: Up Regulation, CD36 Nov 29, 2016 Nov 29, 2016
428 351: Increased Mortality 442: Decreased, Population trajectory Nov 29, 2016 Dec 20, 2019 None
432 444: Increased, Atrioventricular block and bradycardia 351: Increased Mortality Nov 29, 2016 Nov 29, 2016 None
433 445: Respiratory distress/arrest 351: Increased Mortality Nov 29, 2016 Dec 20, 2019
434 39: Increased Cholinergic Signaling 351: Increased Mortality Nov 29, 2016 Dec 3, 2016 None
436 266: Decrease, Steroidogenic acute regulatory protein (STAR) 447: Reduction, Cholesterol transport in mitochondria Nov 29, 2016 Apr 8, 2025
437 289: Decrease, Translocator protein (TSPO) 447: Reduction, Cholesterol transport in mitochondria Nov 29, 2016 Dec 2, 2016
438 447: Reduction, Cholesterol transport in mitochondria 413: Reduction, Testosterone synthesis in Leydig cells Nov 29, 2016 Dec 2, 2016
439 413: Reduction, Testosterone synthesis in Leydig cells 446: Reduction of testosterone Nov 29, 2016 Dec 2, 2016 None
442 424: Inhibition, Na+/I- symporter (NIS) 425: Thyroidal Iodide, Decreased Nov 29, 2016 May 29, 2018
443 425: Thyroidal Iodide, Decreased 281: T4 in serum, Decreased Nov 29, 2016 Nov 29, 2016 None
444 280: T4 in neuronal tissue, Decreased 381: BDNF, Reduced Nov 29, 2016 Apr 4, 2019
445 381: BDNF, Reduced 427: Down Regulation, K-Cl co-transporter 2 (KCC2) Nov 29, 2016 Dec 3, 2016 None
446 427: Down Regulation, K-Cl co-transporter 2 (KCC2) 428: Delay, Developmental GABA shift Nov 29, 2016 Dec 3, 2016 None
447 428: Delay, Developmental GABA shift 385: Synaptogenesis, Decreased Nov 29, 2016 Dec 3, 2016 None
448 381: BDNF, Reduced 385: Synaptogenesis, Decreased Nov 29, 2016 Apr 4, 2019