Key Event Relationships (KERs)

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Showing 201 to 225 of 3130 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
376 396: Covalent Binding, Protein 397: Response, Keratinocytes Nov 29, 2016 Dec 3, 2016 None
378 397: Response, Keratinocytes 398: Activation, Dendritic Cells Nov 29, 2016 Nov 29, 2016 None
395 228: demethylation, PPARg promoter 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Nov 29, 2016 Dec 3, 2016 None
380 397: Response, Keratinocytes 272: Activation/Proliferation, T-cells Nov 29, 2016 Dec 3, 2016 None
383 279: Thyroperoxidase, Inhibition 402: Cognitive function, decreased Nov 29, 2016 Dec 3, 2016 None
393 405: disrupted, ovarian cycle 330: Decrease, Fertility Nov 29, 2016 Dec 3, 2016 None
389 168: Decreased, Lymphocytes 323: Increased, Disease susceptibility Nov 29, 2016 Dec 3, 2016 None
168 158: N/A, Interferences with SH-/selen-proteins 130: Depletion, GSH Nov 29, 2016 Dec 3, 2016 None
228 201: Binding of antagonist, NMDA receptors 341: Impairment, Learning and memory Nov 29, 2016 Dec 3, 2016 None
215 195: Inhibition, NMDARs 191: Neuronal dysfunction Nov 29, 2016 Dec 3, 2016 None
214 195: Inhibition, NMDARs 341: Impairment, Learning and memory Nov 29, 2016 Dec 3, 2016 None
210 191: Neuronal dysfunction 188: Neuroinflammation Nov 29, 2016 Nov 29, 2016 None
200 351: Increased Mortality 361: Decline, Population Nov 29, 2016 Dec 3, 2016 None
199 350: Increase, Mortality 361: Decline, Population Nov 29, 2016 Dec 3, 2016 None
198 350: Increase, Mortality 328: Decrease, Fecundity Nov 29, 2016 Dec 3, 2016 None
197 183: Abnormal, Morphogenesis 366: Increased, Structural malformations Nov 29, 2016 Dec 3, 2016 None
196 183: Abnormal, Morphogenesis 342: Increased, Lethality Nov 29, 2016 Dec 3, 2016 None
88 75: N/A, Covalent binding to protein, possibly lysine residue 151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways Nov 29, 2016 Sep 24, 2020 None
147 134: Increase, Kupffer cell activation 276: Up Regulation, TGFbeta1 expression Nov 29, 2016 Nov 29, 2016 None
146 134: Increase, Kupffer cell activation 209: Peptide Oxidation Nov 29, 2016 Dec 3, 2016 None
135 328: Decrease, Fecundity 361: Decline, Population Nov 29, 2016 Dec 3, 2016 None
96 80: Up Regulation, CYP1A1 209: Peptide Oxidation Nov 29, 2016 Dec 3, 2016 None
104 84: Up Regulation, CYP1B1 3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Nov 29, 2016 Dec 3, 2016 None
116 103: Increase, EcR hyperactivation 60: Induction, Chitin degradation and resorption Nov 29, 2016 Dec 3, 2016 None
360 387: Binding of agonist, NMDARs 388: Overactivation, NMDARs Nov 29, 2016 Nov 29, 2016 None