Key Event Relationships (KERs)

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Showing 201 to 225 of 3131 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
449 12: AchE Inhibition 444: Increased, Atrioventricular block and bradycardia Nov 29, 2016 Dec 3, 2016 None
450 12: AchE Inhibition 445: Respiratory distress/arrest Nov 29, 2016 Dec 20, 2019
451 12: AchE Inhibition 39: Increased Cholinergic Signaling Nov 29, 2016 Dec 20, 2019
452 12: AchE Inhibition 351: Increased Mortality Nov 29, 2016 Dec 20, 2019
453 12: AchE Inhibition 442: Decreased, Population trajectory Nov 29, 2016 Dec 20, 2019 None
454 10: ACh Synaptic Accumulation 444: Increased, Atrioventricular block and bradycardia Nov 29, 2016 Nov 29, 2016 None
456 10: ACh Synaptic Accumulation 39: Increased Cholinergic Signaling Nov 29, 2016 Dec 20, 2019
457 39: Increased Cholinergic Signaling 445: Respiratory distress/arrest Nov 29, 2016 Dec 20, 2019
459 10: ACh Synaptic Accumulation 12: AchE Inhibition Nov 29, 2016 Dec 3, 2016
460 446: Reduction of testosterone 414: Increase, Luteinizing hormone (LH) Nov 29, 2016 Dec 3, 2016 None
461 414: Increase, Luteinizing hormone (LH) 416: Increase proliferation, Leydig cell Nov 29, 2016 Dec 3, 2016
462 415: Hyperplasia, Leydig cell 406: decreased, Fertility Nov 29, 2016 Dec 3, 2016
472 327: Accumulation, Fatty acid 291: Accumulation, Triglyceride Nov 29, 2016 May 28, 2024
473 18: Activation, AhR 451: Inhibition, Mitochondrial fatty acid beta-oxidation Nov 29, 2016 Dec 3, 2016
475 451: Inhibition, Mitochondrial fatty acid beta-oxidation 327: Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
476 456: Suppression, Constitutive androstane receptor, NR1I3 167: Activation, LXR Nov 29, 2016 Dec 3, 2016
477 456: Suppression, Constitutive androstane receptor, NR1I3 228: demethylation, PPARg promoter Nov 29, 2016 Dec 3, 2016
479 167: Activation, LXR 457: Activation, SREBF1 Nov 29, 2016 Dec 3, 2016
482 457: Activation, SREBF1 458: Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016 None
483 66: Activation, ChREBP 458: Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016
484 458: Increased, De Novo FA synthesis 454: Increased, Triglyceride formation Nov 29, 2016 Dec 3, 2016 None
486 454: Increased, Triglyceride formation 459: Increase, Liver steatosis Nov 29, 2016 Dec 3, 2016
487 228: demethylation, PPARg promoter 457: Activation, SREBF1 Nov 29, 2016 Dec 3, 2016
489 457: Activation, SREBF1 462: Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
490 167: Activation, LXR 463: Up Regulation, FAS Nov 29, 2016 Dec 3, 2016