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Showing 1 to 25 of 3131 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3798	245: Activation, PXR/SXR	2429: Instability of INSIG1	Jun 9, 2026	Jun 9, 2026	None
3707	2399: FGF10/FGFR2-IIIb signaling in genital tissue, reduced	2400: Preputial epithelial morphogenesis, disrupted	Dec 16, 2025	Jun 4, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
3748	2414: COL3A1 Signaling Pathway	1195: modulation, Extracellular Matrix Composition	Mar 25, 2026	Jun 4, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3773	1065: Activation, ERα	2417: Increased, differentiation to ovaries	Apr 17, 2026	Jun 2, 2026	1 AOP 641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
3774	2417: Increased, differentiation to ovaries	2418: Increased, female-biased sex ratio	Apr 17, 2026	Jun 2, 2026	1 AOP 641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
3770	1075: prolonged, estrus cycle	406: decreased, Fertility	Apr 6, 2026	Jun 2, 2026	1 AOP 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3761	2294: Plasma E2, increased	2415: Precocious puberty	Mar 26, 2026	Jun 2, 2026	1 AOP 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release
3746	2294: Plasma E2, increased	2413: Increased, uterine weight	Mar 13, 2026	Jun 2, 2026	1 AOP 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining
3717	2402: Increased, E2 production in ovaries	2294: Plasma E2, increased	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3718	2294: Plasma E2, increased	2306: Persistent vaginal cornification	Jan 29, 2026	Jun 2, 2026	1 AOP 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release
3716	2137: Increase, Gonadotropins concentration in plasma	2402: Increased, E2 production in ovaries	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3715	1047: Increased, secretion of GnRH from hypothalamus	2137: Increase, Gonadotropins concentration in plasma	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3714	1985: Increased Kisspeptin levels in AVPV	1047: Increased, secretion of GnRH from hypothalamus	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
2665	1065: Activation, ERα	1985: Increased Kisspeptin levels in AVPV	Jun 6, 2022	Jun 2, 2026	5 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3646	1065: Activation, ERα	968: Decreased, release of kisspeptin from AVPV neurons	Oct 2, 2025	Jun 2, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
3649	1986: Decreased, Gonadotropins	1075: prolonged, estrus cycle	Oct 2, 2025	Jun 2, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
3648	530: Decreased, GnRH pulsatility/release	1075: prolonged, estrus cycle	Oct 2, 2025	Jun 2, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
3647	968: Decreased, release of kisspeptin from AVPV neurons	530: Decreased, GnRH pulsatility/release	Oct 2, 2025	Jun 2, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
3645	2370: A1AR Agonism	2371: Increased cortisol	Oct 1, 2025	May 29, 2026	1 AOP 604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression
3797	1635: Increase, DNA strand breaks	55: Cell injury/death	May 12, 2026	May 12, 2026	1 AOP 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death
3706	2393: AR transcriptional activity in GT tissues, reduced	2399: FGF10/FGFR2-IIIb signaling in genital tissue, reduced	Dec 16, 2025	May 7, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
3796	2423: Hepatic SHP, decreased	1421: Activated, LXR	Apr 28, 2026	Apr 28, 2026	1 AOP 232: NFE2/Nrf2 repression to steatosis
3795	2421: FXR inhibition	2423: Hepatic SHP, decreased	Apr 28, 2026	Apr 28, 2026	1 AOP 232: NFE2/Nrf2 repression to steatosis
3794	1417: NFE2/Nrf2 repression	2421: FXR inhibition	Apr 28, 2026	Apr 28, 2026	1 AOP 232: NFE2/Nrf2 repression to steatosis
3793	902: Inflammation, Liver	1489: Increase, Steatohepatitis	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation

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