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All KERs

Showing 26 to 50 of 3158 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3804	2430: AhR activation	2431: Impact on sirtuins-related aging signaling pathway gene expression	Jul 9, 2026	Jul 9, 2026	None
3803	2430: AhR activation	1392: Increase, Oxidative Stress	Jul 9, 2026	Jul 9, 2026	1 AOP 645: Binding and activation of AhR lead to cardiovascular aging
3708	2400: Preputial epithelial morphogenesis, disrupted	2401: Male PPS, failed/delayed	Dec 16, 2025	Jul 7, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
1910	155: Inadequate DNA repair	1635: Increase, DNA strand breaks	May 19, 2019	Jul 3, 2026	6 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 322: Alkylation of DNA leading to decreased sperm count 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death 644: Bulky DNA adducts leading to chromosomal aberrations and mutations
3802	1262: Apoptosis	1757: Decrease, Sperm count	Jul 3, 2026	Jul 3, 2026	1 AOP 322: Alkylation of DNA leading to decreased sperm count
2075	1365: Increase, Apoptosis	1757: Decrease, Sperm count	Apr 6, 2020	Jul 3, 2026	None
3801	1635: Increase, DNA strand breaks	1262: Apoptosis	Jul 3, 2026	Jul 3, 2026	1 AOP 322: Alkylation of DNA leading to decreased sperm count
2074	1635: Increase, DNA strand breaks	1365: Increase, Apoptosis	Apr 6, 2020	Jul 3, 2026	None
3771	97: Alkylation, DNA	1757: Decrease, Sperm count	Apr 7, 2026	Jul 2, 2026	1 AOP 322: Alkylation of DNA leading to decreased sperm count
3800	1879: Bulky DNA adducts, increase	1635: Increase, DNA strand breaks	Jun 29, 2026	Jun 29, 2026	1 AOP 644: Bulky DNA adducts leading to chromosomal aberrations and mutations
3773	1065: Activation, ERα	2417: Increased, differentiation to ovaries	Apr 17, 2026	Jun 24, 2026	1 AOP 641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
3797	1635: Increase, DNA strand breaks	55: Cell injury/death	May 12, 2026	Jun 23, 2026	1 AOP 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death
3363	1505: Cell cycle disruption	1821: Decrease, Cell proliferation	Oct 8, 2024	Jun 23, 2026	4 AOPs 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption
2767	55: Cell injury/death	1521: Decrease, Growth	Sep 27, 2022	Jun 23, 2026	9 AOPs 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
2768	1771: Decrease, ATP pool	55: Cell injury/death	Sep 27, 2022	Jun 23, 2026	5 AOPs 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
3633	1767: Increase, Protein oxidation	1446: Decrease, Coupling of OXPHOS	Sep 8, 2025	Jun 23, 2026	3 AOPs 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
1599	1445: Increase, LPO	1446: Decrease, Coupling of OXPHOS	Jun 29, 2017	Jun 23, 2026	2 AOPs 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation
3632	1392: Increase, Oxidative Stress	1767: Increase, Protein oxidation	Sep 8, 2025	Jun 23, 2026	7 AOPs 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
3116	1392: Increase, Oxidative Stress	1445: Increase, LPO	Jan 24, 2024	Jun 23, 2026	3 AOPs 521: Essential element imbalance leads to reproductive failure via oxidative stress 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation
2009	1115: Increase, ROS	1392: Increase, Oxidative Stress	Dec 3, 2019	Jun 23, 2026	25 AOPs 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 521: Essential element imbalance leads to reproductive failure via oxidative stress 186: unknown MIE leading to renal failure and mortality 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 462: Activation of reactive oxygen species leading the atherosclerosis 396: Deposition of ionizing energy leads to population decline via impaired meiosis 26: Calcium-mediated neuronal ROS production and energy imbalance 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 595: Emerging OPFRS reproductive outcome pathway 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 472: DNA adduct formation leading to kidney failure 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
1702	1495: Interaction with the lung cell membrane	1496: Increased proinflammatory mediators	Jan 5, 2018	Jun 22, 2026	3 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 451: Interaction with lung resident cell membrane components leads to lung cancer 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
3798	245: Activation, PXR/SXR	2429: Instability of INSIG1	Jun 9, 2026	Jun 9, 2026	None
3707	2399: FGF10/FGFR2-IIIb signaling in genital tissue, reduced	2400: Preputial epithelial morphogenesis, disrupted	Dec 16, 2025	Jun 4, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
3748	2414: COL3A1 Signaling Pathway	1195: modulation, Extracellular Matrix Composition	Mar 25, 2026	Jun 4, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3774	2417: Increased, differentiation to ovaries	2418: Increased, female-biased sex ratio	Apr 17, 2026	Jun 2, 2026	1 AOP 641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries

Key Event Relationships (KERs)

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