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Showing 51 to 75 of 3158 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2104	1775: Increase, Oocyte apoptosis	1366: Decrease, Oogenesis	Apr 30, 2020	Apr 30, 2020	5 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 338: DNA methyltransferase inhibition leading to population decline (3) 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 396: Deposition of ionizing energy leads to population decline via impaired meiosis 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2336	1863: Decrease, Reproduction	360: Decrease, Population growth rate	Apr 11, 2021	Apr 11, 2021	5 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
1909	1634: Increase, Oxidative DNA damage	155: Inadequate DNA repair	May 19, 2019	Mar 8, 2024	5 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 478: Deposition of energy leading to occurrence of cataracts 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death
1703	1496: Increased proinflammatory mediators	1497: Recruitment of inflammatory cells	Jan 5, 2018	May 18, 2023	5 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 409: Frustrated phagocytosis leads to malignant mesothelioma 451: Interaction with lung resident cell membrane components leads to lung cancer 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
1744	1524: Increase, Premature molting	350: Increase, Mortality	May 24, 2018	Feb 17, 2021	5 AOPs 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
1144	560: Abnormal, Foraging activity and behavior	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	5 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 180: Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure 182: Weather event contributes abnormal foraging leading to colony loss/failure 183: Nosema infection increases energetic demands leading to colony loss/failure
1436	1347: Decreased, extracellular serotonin	1328: Inactivated, 5-HTR	Apr 14, 2017	Apr 14, 2017	5 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression
2768	1771: Decrease, ATP pool	55: Cell injury/death	Sep 27, 2022	Jun 23, 2026	5 AOPs 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
2665	1065: Activation, ERα	1985: Increased Kisspeptin levels in AVPV	Jun 6, 2022	Jun 2, 2026	5 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
2497	1901: IFN-I response, antagonized	1847: SARS-CoV-2 production	Oct 24, 2021	Dec 14, 2023	5 AOPs 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2496	1738: SARS-CoV-2 cell entry	1901: IFN-I response, antagonized	Oct 24, 2021	Dec 12, 2023	5 AOPs 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2478	295: Induction, Upregulation of glucuronyltransferase activity	961: Increased, Clearance of thyroxine from serum	Sep 10, 2021	Sep 10, 2021	4 AOPs 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
2460	1115: Increase, ROS	1445: Increase, LPO	Aug 5, 2021	Apr 11, 2024	4 AOPs 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 521: Essential element imbalance leads to reproductive failure via oxidative stress 329: Excessive reactive oxygen species production leading to mortality (3)
2548	1686: Energy Deposition	1115: Increase, ROS	Jan 21, 2022	Jan 21, 2022	4 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2552	1686: Energy Deposition	1194: Increase, DNA Damage	Jan 21, 2022	Jan 21, 2022	4 AOPs 388: Deposition of ionising energy leading to population decline via programmed cell death 435: Deposition of ionising energy leads to population decline via pollen abnormal 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2375	1643: Altered, Visual function	351: Increased Mortality	May 11, 2021	Jul 8, 2022	4 AOPs 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
515	327: Accumulation, Fatty acid	459: Increase, Liver steatosis	Nov 29, 2016	Dec 3, 2016	4 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 57: AhR activation leading to hepatic steatosis
563	566: impaired, Larval development	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	4 AOPs 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
583	341: Impairment, Learning and memory	560: Abnormal, Foraging activity and behavior	Nov 29, 2016	Dec 3, 2016	4 AOPs 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
908	177: Increase, Mitochondrial dysfunction	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	Nov 29, 2016	Oct 3, 2025	4 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits
747	756: Hippocampal gene expression, Altered	757: Hippocampal anatomy, Altered	Nov 29, 2016	Aug 11, 2018	4 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
872	425: Thyroidal Iodide, Decreased	277: TH synthesis, Decreased	Nov 29, 2016	Jun 4, 2018	4 AOPs 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
2038	281: T4 in serum, Decreased	1003: Decreased, Triiodothyronine (T3)	Feb 19, 2020	Oct 10, 2022	4 AOPs 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
3714	1985: Increased Kisspeptin levels in AVPV	1047: Increased, secretion of GnRH from hypothalamus	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3715	1047: Increased, secretion of GnRH from hypothalamus	2137: Increase, Gonadotropins concentration in plasma	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle

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