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Showing 101 to 125 of 3158 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3725	2405: Increase, Hepatocellular lipotoxicity	177: Increase, Mitochondrial dysfunction	Feb 10, 2026	Feb 10, 2026	1 AOP 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction
3724	459: Increase, Liver steatosis	2405: Increase, Hepatocellular lipotoxicity	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
3723	115: Increase, FA influx	459: Increase, Liver steatosis	Feb 10, 2026	Feb 10, 2026	None
3722	2408: Increase, Adipose lipolysis	115: Increase, FA influx	Feb 10, 2026	Feb 10, 2026	None
3721	2119: Increase, Insulin resistance	2408: Increase, Adipose lipolysis	Feb 10, 2026	Feb 10, 2026	3 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
3720	2409: Decrease, 11β-HSD2 activity	2119: Increase, Insulin resistance	Feb 10, 2026	Feb 10, 2026	None
3719	1545: Decrease in mitochondrial oxidative phosphorylation	1771: Decrease, ATP pool	Feb 4, 2026	Feb 4, 2026	None
3718	2294: Plasma E2, increased	2306: Persistent vaginal cornification	Jan 29, 2026	Jul 9, 2026	1 AOP 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release
3717	2402: Increased, E2 production in ovaries	2294: Plasma E2, increased	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3716	2137: Increase, Gonadotropins concentration in plasma	2402: Increased, E2 production in ovaries	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3715	1047: Increased, secretion of GnRH from hypothalamus	2137: Increase, Gonadotropins concentration in plasma	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3714	1985: Increased Kisspeptin levels in AVPV	1047: Increased, secretion of GnRH from hypothalamus	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3713	1445: Increase, LPO	902: Inflammation, Liver	Jan 19, 2026	Jan 19, 2026	1 AOP 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
3712	1417: NFE2/Nrf2 repression	1445: Increase, LPO	Jan 19, 2026	Jan 19, 2026	1 AOP 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
3711	1028: Activation of specific nuclear receptors, PPAR-gamma activation	202: Inhibition, Nuclear factor kappa B (NF-kB)	Jan 16, 2026	Jan 16, 2026	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3710	2341: TCA cycle, disrupted	178: Mitochondrial electron transport chain, disrupted	Jan 7, 2026	Jan 7, 2026	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
3709	2342: Fe-S cluster assembly, impaired	178: Mitochondrial electron transport chain, disrupted	Jan 7, 2026	Jan 7, 2026	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
3708	2400: Preputial epithelial morphogenesis, disrupted	2401: Male PPS, failed/delayed	Dec 16, 2025	Jul 7, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
3707	2399: FGF10/FGFR2-IIIb signaling in genital tissue, reduced	2400: Preputial epithelial morphogenesis, disrupted	Dec 16, 2025	Jun 4, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
3706	2393: AR transcriptional activity in GT tissues, reduced	2399: FGF10/FGFR2-IIIb signaling in genital tissue, reduced	Dec 16, 2025	May 7, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
3705	26: Antagonism, Androgen receptor	2393: AR transcriptional activity in GT tissues, reduced	Dec 16, 2025	Apr 8, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
3704	2395: Diminished proliferation of activated B lymphocytes	2396: Diminished differentiation of activated B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3703	2394: Lower survival B lymphocytes	2395: Diminished proliferation of activated B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3702	2398: Reduced antibody production	2397: Diminished vaccine response	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3701	2396: Diminished differentiation of activated B lymphocytes	2398: Reduced antibody production	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response

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