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Showing 126 to 150 of 3158 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1010	993: Decrease, Abdominal muscle contraction	990: Increase, Incomplete ecdysis	Nov 29, 2016	Dec 3, 2016	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
1035	1003: Decreased, Triiodothyronine (T3)	1007: Reduced, Anterior swim bladder inflation	Nov 29, 2016	Oct 7, 2022	3 AOPs 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
1034	1007: Reduced, Anterior swim bladder inflation	1005: Reduced, Swimming performance	Nov 29, 2016	Oct 7, 2022	3 AOPs 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
1134	1097: Occurrence, renal proximal tubular necrosis	1098: Increased, blood potassium concentration	Nov 29, 2016	Dec 3, 2016	3 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
1140	1098: Increased, blood potassium concentration	1106: Occurrence, cardiac arrhythmia	Nov 29, 2016	Dec 3, 2016	3 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
1141	1106: Occurrence, cardiac arrhythmia	351: Increased Mortality	Nov 29, 2016	Dec 3, 2016	3 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
1151	1108: Abnormal, Role change within caste	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	3 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 184: Nosema infection causes abnormal role change that leads to colony loss/failure
1247	1182: Increase, Cell Proliferation (Epithelial Cells)	1192: Increased, Ductal Hyperplasia	Nov 29, 2016	Dec 3, 2016	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1252	1192: Increased, Ductal Hyperplasia	1193: N/A, Breast Cancer	Nov 29, 2016	May 8, 2019	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
442	424: Inhibition, Na+/I- symporter (NIS)	425: Thyroidal Iodide, Decreased	Nov 29, 2016	May 29, 2018	3 AOPs 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
188	178: Mitochondrial electron transport chain, disrupted	40: Mitochondrial ATP production, decreased	Nov 29, 2016	Dec 3, 2016	3 AOPs 26: Calcium-mediated neuronal ROS production and energy imbalance 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
128	111: Agonism, Estrogen receptor	307: Increase, Vitellogenin synthesis in liver	Nov 29, 2016	Jun 24, 2024	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
365	55: Cell injury/death	188: Neuroinflammation	Nov 29, 2016	Jul 15, 2022	3 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
394	405: disrupted, ovarian cycle	406: decreased, Fertility	Nov 29, 2016	Mar 18, 2025	3 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 345: Androgen receptor (AR) antagonism leading to decreased fertility in females
336	307: Increase, Vitellogenin synthesis in liver	220: Increase, Plasma vitellogenin concentrations	Nov 29, 2016	Jun 24, 2024	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
24	97: Alkylation, DNA	155: Inadequate DNA repair	Nov 29, 2016	Dec 10, 2019	3 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 139: Alkylation of DNA leading to cancer 1 322: Alkylation of DNA leading to decreased sperm count
1939	1635: Increase, DNA strand breaks	1636: Increase, Chromosomal aberrations	Jun 3, 2019	Jan 9, 2023	3 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 644: Bulky DNA adducts leading to chromosomal aberrations and mutations
2479	1158: Increased, Hepatic thyroid hormone uptake/transport	961: Increased, Clearance of thyroxine from serum	Sep 10, 2021	Sep 10, 2021	3 AOPs 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
2422	281: T4 in serum, Decreased	1023: Increased, Thyroid-stimulating hormone (TSH)	Jul 7, 2021	Jul 7, 2021	3 AOPs 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
2424	1023: Increased, Thyroid-stimulating hormone (TSH)	739: Increase, Hypertrophy and proliferation (follicular cell)	Jul 7, 2021	Jul 7, 2021	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
2443	1909: MCC, Decreased	1250: Decreased lung function	Jul 19, 2021	Mar 24, 2023	3 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
2442	1908: CBF, Decreased	1909: MCC, Decreased	Jul 19, 2021	Mar 24, 2023	3 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
456	10: ACh Synaptic Accumulation	39: Increased Cholinergic Signaling	Nov 29, 2016	Dec 20, 2019	3 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
501	54: Up Regulation, CD36	465: Increased, FA Influx	Nov 29, 2016	Dec 3, 2016	3 AOPs 57: AhR activation leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis
505	465: Increased, FA Influx	327: Accumulation, Fatty acid	Nov 29, 2016	Dec 3, 2016	3 AOPs 57: AhR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis

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