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Showing 176 to 200 of 3158 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3650	2363: Mito ROS dysfunction	889: Proteostasis, impaired	Oct 3, 2025	Oct 3, 2025	1 AOP 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
3649	1986: Decreased, Gonadotropins	1075: prolonged, estrus cycle	Oct 2, 2025	Jun 2, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
3648	530: Decreased, GnRH pulsatility/release	1075: prolonged, estrus cycle	Oct 2, 2025	Jun 2, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
3647	968: Decreased, release of kisspeptin from AVPV neurons	530: Decreased, GnRH pulsatility/release	Oct 2, 2025	Jun 2, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
3646	1065: Activation, ERα	968: Decreased, release of kisspeptin from AVPV neurons	Oct 2, 2025	Jun 2, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
3645	2370: A1AR Agonism	2371: Increased cortisol	Oct 1, 2025	May 29, 2026	1 AOP 604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression
3644	2375: Decrease, Mis-timed EcR-responsive NR cascade	1522: Inhibition, CHS-1	Sep 29, 2025	Sep 29, 2025	1 AOP 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
3643	2375: Decrease, Mis-timed EcR-responsive NR cascade	988: Decrease, Circulating ETH	Sep 29, 2025	Sep 29, 2025	1 AOP 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
3642	2374: Increase, EcR antagonism	2375: Decrease, Mis-timed EcR-responsive NR cascade	Sep 29, 2025	Sep 29, 2025	2 AOPs 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
3641	2373: Increase, Mis-timed EcR-responsive NR cascade	988: Decrease, Circulating ETH	Sep 29, 2025	Sep 29, 2025	1 AOP 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
3640	103: Increase, EcR hyperactivation	2373: Increase, Mis-timed EcR-responsive NR cascade	Sep 29, 2025	Sep 29, 2025	1 AOP 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
3639	1267: Decrease, Ecdysis motor program activity	993: Decrease, Abdominal muscle contraction	Sep 29, 2025	Sep 29, 2025	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
3638	2258: Inhibition, monocarboxylate transporter 8 (MCT8)	280: T4 in neuronal tissue, Decreased	Sep 29, 2025	Sep 29, 2025	None
3637	1542: Inhibition, Mitochondrial complex III	177: Increase, Mitochondrial dysfunction	Sep 24, 2025	Oct 2, 2025	1 AOP 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits
3636	1767: Increase, Protein oxidation	1505: Cell cycle disruption	Sep 8, 2025	Sep 8, 2025	1 AOP 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption
3635	179: Decrease, Fatty acid β-oxidation	1771: Decrease, ATP pool	Sep 8, 2025	Sep 8, 2025	3 AOPs 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
3634	1767: Increase, Protein oxidation	179: Decrease, Fatty acid β-oxidation	Sep 8, 2025	Sep 8, 2025	3 AOPs 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
3633	1767: Increase, Protein oxidation	1446: Decrease, Coupling of OXPHOS	Sep 8, 2025	Jun 23, 2026	3 AOPs 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
3632	1392: Increase, Oxidative Stress	1767: Increase, Protein oxidation	Sep 8, 2025	Jun 23, 2026	7 AOPs 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
3629	2362: Redox cycling	2363: Mito ROS dysfunction	Sep 7, 2025	Oct 3, 2025	1 AOP 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
3628	2274: Androgen receptor activation, increased	2365: AGD, increased	Sep 5, 2025	Sep 5, 2025	1 AOP 547: Androgen receptor agonism leading to long anogenital distance in female offspring
3627	1066: Promotion, SIX1 positive progenitor cells in endometrium	772: Increase, Hyperplasia (glandular epithelial cells of endometrium)	Sep 3, 2025	Sep 18, 2025	1 AOP 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
3626	1066: Promotion, SIX1 positive progenitor cells in endometrium	1068: Endometrial squamous metaplasia, Increase	Sep 3, 2025	Sep 18, 2025	1 AOP 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
3625	1696: Decrease of egg production and cummulative fecundity	1863: Decrease, Reproduction	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3624	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	1696: Decrease of egg production and cummulative fecundity	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway

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