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Showing 201 to 225 of 3158 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3366	2268: Decreased, INSIG1 protein activity	2269: Increased, SREBP2 protein expression	Oct 22, 2024	Feb 10, 2025	2 AOPs 545: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis 548: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
3355	2266: Demyelination, increased	2267: Delayed neuropathy, increased	Oct 1, 2024	Oct 1, 2024	2 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
3351	2262: NTE, inhibited	2263: LPS, increased	Oct 1, 2024	Oct 1, 2024	2 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
3354	2265: Oligodendrocyte death, increased	2266: Demyelination, increased	Oct 1, 2024	Oct 1, 2024	2 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
3434	2291: Bradycardia	2292: Altered Cardiac Electrical Conduction	Nov 22, 2024	Nov 22, 2024	2 AOPs 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias
3435	2292: Altered Cardiac Electrical Conduction	1106: Occurrence, cardiac arrhythmia	Nov 22, 2024	Nov 22, 2024	2 AOPs 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias
3405	2280: Prolonged atrioventricular (AV)	1106: Occurrence, cardiac arrhythmia	Nov 20, 2024	Nov 20, 2024	2 AOPs 551: Increased Muscarinic M2 Receptor leading to Arrhythmia 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
3426	389: Increased, Intracellular Calcium overload	1532: Decrease, Cardiac contractility	Nov 21, 2024	Nov 21, 2024	2 AOPs 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
3392	25: Agonism, Androgen receptor	286: Altered, Transcription of genes by the AR	Nov 16, 2024	Nov 16, 2024	2 AOPs 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 495: Androgen receptor activation leading to prostate cancer
2792	1262: Apoptosis	2041: Decrease, facial prominence outgrowth	Oct 27, 2022	Apr 4, 2025	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
2821	105: Inhibition, ETC complexes of the respiratory chain	177: Increase, Mitochondrial dysfunction	Jan 5, 2023	Jan 5, 2023	2 AOPs 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
2822	177: Increase, Mitochondrial dysfunction	40: Mitochondrial ATP production, decreased	Jan 5, 2023	Jan 5, 2023	2 AOPs 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 258: Renal protein alkylation leading to kidney toxicity
2776	1392: Increase, Oxidative Stress	2068: Increase, Endothelial Dysfunction	Sep 28, 2022	Aug 27, 2024	2 AOPs 470: Deposition of energy leads to abnormal vascular remodeling 462: Activation of reactive oxygen species leading the atherosclerosis
1979	1636: Increase, Chromosomal aberrations	870: Increase, Cell Proliferation	Aug 29, 2019	Mar 8, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1978	185: Increase, Mutations	870: Increase, Cell Proliferation	Aug 29, 2019	Mar 8, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1967	870: Increase, Cell Proliferation	1670: Lung cancer	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 451: Interaction with lung resident cell membrane components leads to lung cancer
1966	1669: Increased, DNA damage and mutation	870: Increase, Cell Proliferation	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 451: Interaction with lung resident cell membrane components leads to lung cancer
1965	1115: Increase, ROS	1669: Increased, DNA damage and mutation	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
1964	1497: Recruitment of inflammatory cells	1115: Increase, ROS	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
1963	87: Release, Cytokine	1497: Recruitment of inflammatory cells	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1981	1686: Energy Deposition	185: Increase, Mutations	Aug 29, 2019	Dec 17, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1982	1686: Energy Deposition	1636: Increase, Chromosomal aberrations	Aug 29, 2019	Dec 17, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1052	761: Increased, Chloride conductance	1015: Increased, Neuronal synaptic inhibition	Nov 29, 2016	Dec 3, 2016	2 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
1053	1015: Increased, Neuronal synaptic inhibition	1012: Increased, Inhibitory postsynaptic potential	Nov 29, 2016	Dec 3, 2016	2 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
1054	1012: Increased, Inhibitory postsynaptic potential	1014: Induction, Somatic muscle paralysis	Nov 29, 2016	Dec 3, 2016	2 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 471: Neuron defect induced early behavioral change

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