|
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
|
Jinhee Choi |
|
|
|
Alkylation of DNA leading to cancer 1
|
Carole Yauk |
DNA alkylation |
cancer |
|
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
|
Mukesh Patel |
AR |
adverse effects in the male foetus |
|
Calcium-mediated neuronal ROS production and energy imbalance
|
Lyle Burgoon |
unclear |
energy imbalance |
|
Chemical binding to tubulin in oocytes leading to aneuploid offspring
|
Francesco Marchetti |
tubulin? |
aneuploid offspring |
|
ER mediated breast cancer AOP
|
Molly M Morgan |
|
|
|
Estrogen receptor activation leading to breast cancer
|
Molly M Morgan |
|
|
|
Excessive reactive oxygen species production leading to reproductive dysfunction
|
Knut Erik Tollefsen |
|
|
|
Gastric ulcer formation
|
Lyle Burgoon |
|
|
|
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
|
Knut Erik Tollefsen |
|
|
|
Helicobacter pylori to gastric ulcer
|
Lyle Burgoon |
|
|
|
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
|
Florence Pagé-Larivière |
|
|
|
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
|
Florence Pagé-Larivière |
|
|
|
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
|
Michelle Embry |
nitric oxide |
liver tumors |
|
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
|
Knut Erik Tollefsen |
|
|
|
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
|
Jinhee Choi |
|
|
|
Juvenile hormone receptor agonism leading to male offspring induction associated population decline
|
Knut Erik Tollefsen |
|
|
|
Kidney toxicity induced by activation of 5HT2C
|
Kevin Crofton |
5-HTT2c |
kidney toxicity |
|
LXR activation leading to hepatic steatosis
|
Marina Goumenou |
LXR |
liver steatosis |
|
Mental stress to agitation
|
Lyle Burgoon |
|
|
|
Mental stress to depression
|
Lyle Burgoon |
|
|
|
Molecular events lead to epilepsy
|
Lyle Burgoon |
|
|
|
Molecular events lead to nonalcoholic hepatic steatosis (NASH)
|
Lyle Burgoon |
|
|
|
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
|
Timothy Allen |
|
|
|
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans : Case study on silver nanoparticle
|
Jinhee Choi |
|
|
|
Network of SSRIs (selective serotonin reuptake inhibitors)
|
Lyle Burgoon |
|
|
|
NFE2/Nrf2 repression to steatosis
|
Lyle Burgoon |
|
|
|
NSAID induced PTGS1 inactivation to gastric ulcer
|
Lyle Burgoon |
|
|
|
NSAID induced PTGS2 inactivation to gastric ulcer
|
Lyle Burgoon |
|
|
|
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
|
Jinhee Choi |
|
|
|
presynaptic neuron 1 activation to epilepsy
|
Lyle Burgoon |
|
|
|
presynaptic neuron 2 repression to epilepsy
|
Lyle Burgoon |
|
|
|
Serotonin transporter activation to agitation
|
Lyle Burgoon |
|
|
|
Serotonin transporter activation to depression
|
Lyle Burgoon |
|
|
|
Serotonin transporter activation to seizure
|
Lyle Burgoon |
|
|
|
SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
Lyle Burgoon |
|
|
|
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
|
Jeanelle Martinez |
|
|