AOPs With SAAOP Status


Proposed for OECD Work Plan

Under development: Not open for comment. Do not cite

Under Development

Open for citation & comment

Title Point of Contact MIE AO
Ecdysone receptor agonism leading to mortality Knut Erik Tollefsen EcR mortality

Open for comment. Do not cite

Title Point of Contact MIE AO
AOP from chemical insult to cell death Mathieu Vinken

Under development: Not open for comment. Do not cite

Title Point of Contact MIE AO
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi
Alkylation of DNA leading to cancer 1 Carole Yauk DNA alkylation cancer
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel AR adverse effects in the male foetus
Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon unclear energy imbalance
Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti tubulin? aneuploid offspring
ER mediated breast cancer AOP Molly M Morgan
Estrogen receptor activation leading to breast cancer Molly M Morgan
Excessive reactive oxygen species production leading to reproductive dysfunction Knut Erik Tollefsen
Gastric ulcer formation Lyle Burgoon
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen
Helicobacter pylori to gastric ulcer Lyle Burgoon
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière
Inhibition of fatty acid beta oxidation leading to nonalcoholic hepatic steatosis (NASH) Lyle Burgoon
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Michelle Embry nitric oxide liver tumors
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi
Juvenile hormone receptor agonism leading to male offspring induction associated population decline Knut Erik Tollefsen
Kidney toxicity induced by activation of 5HT2C Kevin Crofton 5-HTT2c kidney toxicity
LXR activation leading to hepatic steatosis Marina Goumenou LXR liver steatosis
Mental stress to agitation Lyle Burgoon
Mental stress to depression Lyle Burgoon
Molecular events lead to epilepsy Lyle Burgoon
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans : Case study on silver nanoparticle Jinhee Choi
Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon
NFE2/Nrf2 repression to steatosis Lyle Burgoon
NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon
NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi
presynaptic neuron 1 activation to epilepsy Lyle Burgoon
presynaptic neuron 2 repression to epilepsy Lyle Burgoon
Serotonin transporter activation to agitation Lyle Burgoon
Serotonin transporter activation to depression Lyle Burgoon
Serotonin transporter activation to seizure Lyle Burgoon
SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Jeanelle Martinez