AOPs With SAAOP Status

Under Development

Open for citation & comment

Title	Point of Contact	MIE	AO
Ecdysone receptor agonism leading to incomplete ecdysis associated mortality	Knut Erik Tollefsen	Increase, Ecdysone receptor agonism

Open for comment. Do not cite

Title	Point of Contact	MIE	AO
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure	Carlie LaLone		impaired, Larval development Death/Failure, Colony
AOP from chemical insult to cell death	Mathieu Vinken	Decompartmentalization Direct mitochondrial inhibition narcosis	Apoptosis Necrosis
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure	Carlie LaLone		impaired, Larval development Death/Failure, Colony
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure	Carlie LaLone		Decrease, Number of worker bees Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1	Carlie LaLone	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure	Carlie LaLone	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste	Carlie LaLone	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1	Carlie LaLone	Activation, Nicotinic acetylcholine receptor	impaired, Larval development Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2	Carlie LaLone	Activation, Nicotinic acetylcholine receptor	impaired, Larval development Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure	Carlie LaLone	Activation, Nicotinic acetylcholine receptor	Decrease, Number of worker bees impaired, Hive thermoregulation Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure	Carlie LaLone	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure	Carlie LaLone	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure	Carlie LaLone		Decrease, Number of worker bees Death/Failure, Colony
Suppression of immune system contributes to impaired development and leads to colony loss/failure	Carlie LaLone		Decrease, Number of worker bees impaired, Hive thermoregulation Death/Failure, Colony

Open for adoption

Title	Point of Contact	MIE	AO
Alkylation of DNA leading to cancer 1	Carole Yauk	Alkylation, DNA	Increase, Cancer
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)	Mukesh Patel	N/A, Androgen receptor, Antagonism	N/A, Impairment of reproductive capacity
Calcium-mediated neuronal ROS production and energy imbalance	Lyle Burgoon	Inhibition, Ca++ ATPase	Increased, Oxidative damage
Estrogen receptor activation leading to breast cancer	Molly M Morgan	Activation, Estrogen receptor	N/A, Breast Cancer
Gastric ulcer formation	Lyle Burgoon		Inhibit, gastric ulcer formation Activated, gastric ulcer formation
Helicobacter pylori to gastric ulcer	Lyle Burgoon	Helicobacter pylori infection	Activated, gastric ulcer formation
Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)	Lyle Burgoon	Inhibition, Fatty Acid Beta Oxidation	N/A, Steatohepatisis
Kidney toxicity induced by activation of 5HT2C	Kevin Crofton	Activation, 5HT2c	Increased, Kidney Failure
Mental stress to agitation	Lyle Burgoon	Increased, glucocorticoid receptor activity	Increased, agitation
Mental stress to depression	Lyle Burgoon	Increased, glucocorticoid receptor activity	Increased, depression
Molecular events lead to epilepsy	Lyle Burgoon		Increase, seizure Increased, hippocampal hyperdepolarization Increased, epilepsy
Network of SSRIs (selective serotonin reuptake inhibitors)	Lyle Burgoon		Increased, seizure Increased, agitation Increased, depression Increase, hypertension
NFE2/Nrf2 repression to steatosis	Lyle Burgoon	NFE2/Nrf2 repression	Increased, steatosis
NSAID induced PTGS1 inactivation to gastric ulcer	Lyle Burgoon	Reduced, PTGS1 function	Activated, gastric ulcer formation
NSAID induced PTGS2 inactivation to gastric ulcer	Lyle Burgoon	Reduced, PTGS2 function	Activated, gastric ulcer formation
presynaptic neuron 1 activation to epilepsy	Lyle Burgoon	Activated, presynaptic neuron 1	Increased, epilepsy
presynaptic neuron 2 repression to epilepsy	Lyle Burgoon	Reduced, presynaptic neuron 2 activity	Increased, epilepsy
Serotonin transporter activation to agitation	Lyle Burgoon		Increased, agitation
Serotonin transporter activation to depression	Lyle Burgoon	Increased, serotonin transporter activity	Increased, depression
Serotonin transporter activation to seizure	Lyle Burgoon	Increased, serotonin transporter activity	Increased, seizure
SSRI (Selective serotonin reuptake inhibitor) to hypertension	Lyle Burgoon	Decreased, serotonin transporter activity	Increase, hypertension

Not under active development

Title	Point of Contact	MIE	AO
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity	Florence Pagé-Larivière	CYP7B activity, inhibition	Decrease, Population growth rate
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior	Florence Pagé-Larivière	CYP7B activity, inhibition	Decrease, Population growth rate
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors	Michelle Embry
LXR activation leading to hepatic steatosis	Marina Goumenou	Activation, LXR peroxisome proliferator activated receptor promoter demethylation	N/A, Liver Steatosis
Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition	Timothy Allen	Mu Opioid Receptor Agonism	Analgesia
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening	Timothy Allen	Mu Opioid Receptor Agonism	Analgesia
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition	Timothy Allen	Serotonin 1A Receptor Agonism	Anti-depressant Activity
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening	Timothy Allen	Serotonin 1A Receptor Agonism	Anti-depressant Activity

Under development: Not open for comment. Do not cite

Title	Point of Contact	MIE	AO
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building	Jinhee Choi		Reproductive failure
Deposition of energy leading to population decline via DNA oxidation and follicular atresia	You Song	Deposition of Energy	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
Deposition of energy leading to population decline via DNA strand breaks and follicular atresia	Knut Erik Tollefsen	Deposition of Energy	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
DNA Adducts Leading to Liver Hemangiosarcoma	Annie Jarabek
ER mediated breast cancer AOP	Molly M Morgan
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality	Knut Erik Tollefsen	Activation, Glutamate-gated chloride channels	Increased Mortality
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality	Knut Erik Tollefsen	Activation, ionotropic GABA Receptor chloride channel	Increased Mortality
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure	Jinhee Choi		Reproductive failure
Mitochondrial ATP synthase antagonism leading to growth inhibition (1)	You Song	Increase, Mitochondrial ATP synthase antagonism	Decrease, Growth
Mitochondrial ATP synthase antagonism leading to growth inhibition (2)	You Song	Increase, Mitochondrial ATP synthase antagonism	Decrease, Growth
Mitochondrial complex III antagonism leading to growth inhibition (1)	You Song	Increase, Mitochondrial complex III antagonism	Decrease, Growth
Mitochondrial complex III antagonism leading to growth inhibition (2)	You Song	Increase, Mitochondrial complex III antagonism	Decrease, Growth
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans	Jinhee Choi	Activation, NADPH Oxidase	Reproductive failure
Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling	Annie Jarabek
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP	Jinhee Choi		Hepatotoxicity
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation	Jeanelle Martinez	TRPA1 activation, TRPA1 Receptor	Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea Irritation of nasal mucosa inducing sneeze reflex Increased Respiratory irritability and Chronic Cough,

Under Development: Contributions and Comments Welcome

Title	Point of Contact	MIE	AO
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline	Kellie Fay	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Increase, predation Decrease, Population growth rate
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase	Kellie Fay	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Increased, Population
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline	Kellie Fay	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Decreased, Reproductive Success Decrease, Population growth rate
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase	Kellie Fay	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Increased, Reproductive Success Increased, Population
AhR activation leading to hepatic steatosis	Michelle Angrish	Activation, AhR	Accumulation, Liver lipid
AKT2 activation leading to hepatic steatosis	Michelle Angrish	systemic inflammation leading to hepatic steatosis	Increased, Liver Steatosis
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation	Tammy Stoker	Inhibition, Antgonism of NE receptor	Decreased, Decreased fecundity
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)	Charles Wood	Increased, Binding of chemicals to 2u (serum)	Increase, Adenomas/carcinomas (renal tubular)
Altered ion channel activity leading impaired heart function	Kevin Dreher	impaired, ion channels	Increased Mortality
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat	Charles Wood		Increased, Adenomas/carcinomas (mammary)
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse	Charles Wood		Promotion, ovarian adenomas Promotion, ovarian granular cell tumors
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats	Tammy Stoker	Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol	Decreased fertility, Reduced number of oocytes ovulated
Axonal sodium channel modulation leading to acute mortality	Kellie Fay	modulation, sodium channel	Increased Mortality
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse	Charles Wood	Activation, beta-2 adrenergic receptor	Promotion, mesovarian leiomyomas
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)	Charles Wood	Increase, Cytotoxicity (hepatocytes)	Increase, hepatocellular adenomas and carcinomas
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.	Charles Wood		Increased, mesotheliomas
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality	Kellie Fay	Inhibition, Cyclooxygenase 1 activity	Increased Mortality Decrease, Population growth rate
Cyclooxygenase inhibition leading reproductive failure	Dan Villeneuve	Inhibition, Cyclooxygenase activity	N/A, Reproductive failure
Cyclooxygenase inhibition leading to reproductive dysfunction	Dalma Martinovic-Weigelt	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior	Dalma Martinovic-Weigelt	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release	Dalma Martinovic-Weigelt	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition	Dalma Martinovic-Weigelt	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint	Dalma Martinovic-Weigelt	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)	Charles Wood	Increase, Cytotoxicity (club cells)	Increase, Adenomas/carcinomas (bronchioloalveolar)
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)	Charles Wood	Increase, Cytotoxicity (tubular epithelial cells)	Increase, Adenomas/carcinomas (renal tubular)
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)	Charles Wood	Decreased, Androgen receptor activity	Increase, Leydig cell tumors
DNA methyltransferase inhibition leading to population decline (1)	You Song	Increase, DNA methyltransferase inhibition	Decrease, Fecundity Decrease, Population growth rate
DNA methyltransferase inhibition leading to population decline (2)	You Song	Increase, DNA methyltransferase inhibition	Decrease, Fecundity Decrease, Population growth rate
DNA methyltransferase inhibition leading to population decline (4)	You Song	Increase, DNA methyltransferase inhibition	Decrease, Fecundity Decrease, Population growth rate
DNA methyltransferase inhibition leading to transgenerational effects (1)	You Song	Increase, DNA methyltransferase inhibition	Decrease, Fecundity (F3) Decrease, Population growth rate
DNA methyltransferase inhibition leading to transgenerational effects (2)	You Song	Increase, DNA methyltransferase inhibition	Decrease, Fecundity (F3) Decrease, Population growth rate
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	Inhibition, Dual oxidase	Altered, Amphibian metamorphosis
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.	Charles Wood	prepubertal increase, Estrogen receptor (ER) activity	Increased, adenosquamous carcinomas of endometrium
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse	Charles Wood		Increase, Adenomas/carcinomas (follicular cell)
Epigenetic modification of PPARG leading to adipogenesis	Michelle Angrish	peroxisome proliferator activated receptor promoter demethylation chronic high fat diet	obesity
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)	Charles Wood	Increase, Cytotoxicity (epithelial cells)	Increase, Papillomas/carcinomas (squamous cells)
ER agonism leading to reduced survival due to renal failure	Tom Hutchinson	Agonism, Estrogen receptor
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males	Tom Hutchinson	Agonism, Estrogen receptor	skewed, sex ratio
Estrogen Receptor Activation and Female Precocious Puberty	Jeff Welch
Estrogen receptor agonism leading to reproductive dysfunction	Tom Hutchinson	Agonism, Estrogen receptor	Decrease, Population growth rate Altered, Reproductive behaviour Altered, Larval development Impaired development of, Reproductive organs
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival	Kellie Fay	Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel	Reduced, survival
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility	Susan Laws	Glucocorticoid Receptor Agonist, Activation	impaired, Fertility
Glutamate-gated chloride channel activation leading to acute mortality	Helen Poynton	Activation, Glutamate-gated chloride channel	Increased Mortality Decreased, population 1
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.	Charles Wood		Increased, Adenomas/carcinomas (mammary)
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.	Charles Wood		Increased, adenomas (pituitary)
Handbook development AOP	Dan Villeneuve
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis	Jonathan Haselman	Activation, Hepatic nuclear receptor(s)	Altered, Amphibian metamorphosis
Histamine (H2) receptor antagonism leading to reduced survival	Kellie Fay	Antagonism, Histamine Receptor (H2)	Decreased, survival Increased, predation
HMG-CoA reductase inhibition leading to decreased fertility	Kellie Fay	Inhibition, HMG-CoA reductase	Decrease, Fertility
HNF4alpha suppression leading to hepatic steatosis	Michelle Angrish	Suppression, HNF4alpha
HPPD inhibition leading to corneal papillomas and carcinomas (in rat)	Charles Wood	Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme	Increase, Papillomas/carcinomas (squamous cells)
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)	Charles Wood	Increase, Dopaminergic activity	Increase, Endometrial adenocarcinomas
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)	Charles Wood	Inhibition, 5α-reductase activity	Increase, Leydig cell tumors
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)	Charles Wood	Inhibition, Na+/I- symporter (NIS)	Increase, Adenomas/carcinomas (follicular cell)
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)	Charles Wood	Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme	Increase, hepatocellular adenomas and carcinomas
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)	Charles Wood	Thyroperoxidase, Inhibition	Increase, Adenomas/carcinomas (follicular cell)
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	Inhibition, Iodotyrosine deiodinase (IYD)	Altered, Amphibian metamorphosis
Juvenile hormone receptor agonism leading to male offspring induction associated population decline	Knut Erik Tollefsen	Activation, Juvenile hormone receptor	Increased, Male offspring Decline, Population Alteration, Food-web structures
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis	Gary Klinefelter	Decreased testosterone by the fetal Leydig cells, Increased corticosterone Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists	Decreased sperm quantity / quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome	Gary Klinefelter	Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome	Decreased sperm quantity / quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell	Gary Klinefelter	Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol Decreased Cholesterol, Decreased Uptake of Lipoproteins Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane	Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis	Gary Klinefelter	Decreased testosterone by the fetal Leydig cells, Increased estradiol Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists	Decreased sperm quantity / quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation	Gary Klinefelter	Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid	Decreased sperm quantity or quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis	Gary Klinefelter	Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis	Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell	Gary Klinefelter	Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell	Decreased sperm quantity or quality in the adult, Decreased fertility
NFE2L2/FXR activation leading to hepatic steatosis	Michelle Angrish	Activation, NRF2 Activation, NR1H4	Increased, Liver Steatosis
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure	Carlie LaLone	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony
Nosema infection causes abnormal role change that leads to colony loss/failure	Carlie LaLone		Death/Failure, Colony
Nosema infection increases energetic demands leading to colony loss/failure	Carlie LaLone		Death/Failure, Colony
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis	Michelle Angrish	Activation, PXR/SXR	Increased, Liver Steatosis
NR1I3 (CAR) suppression leading to hepatic steatosis	Michelle Angrish	Suppression, Constitutive androstane receptor, NR1l3 Inhibition, PPAR alpha Activation, LXR peroxisome proliferator activated receptor promoter demethylation	Increased, Liver Steatosis
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality	Kellie Fay	Inhibition, organic anion transporter 1 (OAT1)	Increased Mortality Decrease, Population growth rate
Pendrin inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	Inhibition, Pendrin	Altered, Amphibian metamorphosis
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis	Michelle Angrish	Decreased, PPAR-alpha activation Decreased, PPAR-beta activation Decreased, PPAR-gamma activation	Increased, Liver Steatosis
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse	Charles Wood		Increased, Pancreatic acinar tumors
PPARgamma activation leading to sarcomas in rats, mice, and hamsters	Charles Wood	Activation of specific nuclear receptors, PPAR-gamma activation
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation	Dalma Martinovic-Weigelt	Inhibition, Prolyl hydroxylases	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
Queen egg-laying decrease leads to colony loss/failure	Carlie LaLone		Death/Failure, Colony
Sodium channel (Nav1.1) inhibition leading to population decline	Kellie Fay	Inhibition, sodium channel
Sodium channel inhibition leading to congenital malformations	Kellie Fay	Inhibition, sodium channel	Increased, amputations
sodium channel inhibition leading to increased predation	Kellie Fay	Inhibition, sodium channel	Increased, predation
Sodium channel inhibition leading to reduced survival	Kellie Fay	Inhibition, sodium channel	Reduced, feeding 1 Increased, predation Reduced, survival
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Mary Gilbert	Inhibition, Na+/I- symporter (NIS)	Cognitive Function, Decreased
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	Inhibition, Na+/I- symporter (NIS)	Altered, Amphibian metamorphosis
Thyroperoxidase inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	Thyroperoxidase, Inhibition	Altered, Amphibian metamorphosis
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	Inhibition, Deiodinase 1	Altered, Amphibian metamorphosis
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	Inhibition, Deiodinase 2	Altered, Amphibian metamorphosis
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	Inhibition, Deiodinase 3	Altered, Amphibian metamorphosis
unknown MIE leading to renal failure and mortality	Kellie Fay	Unknown, MIE	Increased Mortality
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription	Dalma Martinovic-Weigelt	modulation, Unknown	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)	Charles Wood	Increase, Urinary bladder calculi	Increase, Adenomas/carcinomas (urothelial)
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure	Carlie LaLone		Death/Failure, Colony
Varroa mite infestation increases virus levels leading to colony loss/failure	Carlie LaLone		Death/Failure, Colony
Weather event contributes abnormal foraging leading to colony loss/failure	Carlie LaLone		Death/Failure, Colony
Weather event contributes to colony loss/failure	Carlie LaLone		Death/Failure, Colony
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity	Tammy Stoker	Inhibition, Inhibition of Dopamine-beta-hydroxylase	Decreased, Decreased fecundity