AOPs With SAAOP Status

Under Development

Open for citation & comment

Title Point of Contact MIE AO
Ecdysone receptor agonism leading to incomplete ecdysis associated mortality Knut Erik Tollefsen
  • Increase, Ecdysone receptor agonism

Open for comment. Do not cite

Title Point of Contact MIE AO
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Carlie LaLone
  • impaired, Larval development
  • Death/Failure, Colony
AOP from chemical insult to cell death Mathieu Vinken
  • Decompartmentalization
  • Direct mitochondrial inhibition
  • narcosis
  • Apoptosis
  • Necrosis
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Carlie LaLone
  • impaired, Larval development
  • Death/Failure, Colony
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone
  • Decrease, Number of worker bees
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Carlie LaLone
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Carlie LaLone
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Carlie LaLone
  • Activation, Nicotinic acetylcholine receptor
  • impaired, Larval development
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Carlie LaLone
  • Activation, Nicotinic acetylcholine receptor
  • impaired, Larval development
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Carlie LaLone
  • Activation, Nicotinic acetylcholine receptor
  • Decrease, Number of worker bees
  • impaired, Hive thermoregulation
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Carlie LaLone
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Carlie LaLone
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone
  • Decrease, Number of worker bees
  • Death/Failure, Colony
Suppression of immune system contributes to impaired development and leads to colony loss/failure Carlie LaLone
  • Decrease, Number of worker bees
  • impaired, Hive thermoregulation
  • Death/Failure, Colony

Open for adoption

Title Point of Contact MIE AO
Alkylation of DNA leading to cancer 1 Carole Yauk
  • Alkylation, DNA
  • Increase, Cancer
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel
  • N/A, Androgen receptor, Antagonism
  • N/A, Impairment of reproductive capacity
Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon
  • Inhibition, Ca++ ATPase
  • Increased, Oxidative damage
Estrogen receptor activation leading to breast cancer Molly M Morgan
  • Activation, Estrogen receptor
  • N/A, Breast Cancer
Gastric ulcer formation Lyle Burgoon
  • Inhibit, gastric ulcer formation
  • Activated, gastric ulcer formation
Helicobacter pylori to gastric ulcer Lyle Burgoon
  • Helicobacter pylori infection
  • Activated, gastric ulcer formation
Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon
  • Inhibition, Fatty Acid Beta Oxidation
  • N/A, Steatohepatisis
Kidney toxicity induced by activation of 5HT2C Kevin Crofton
  • Activation, 5HT2c
  • Increased, Kidney Failure
Mental stress to agitation Lyle Burgoon
  • Increased, glucocorticoid receptor activity
  • Increased, agitation
Mental stress to depression Lyle Burgoon
  • Increased, glucocorticoid receptor activity
  • Increased, depression
Molecular events lead to epilepsy Lyle Burgoon
  • Increase, seizure
  • Increased, hippocampal hyperdepolarization
  • Increased, epilepsy
Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon
  • Increased, seizure
  • Increased, agitation
  • Increased, depression
  • Increase, hypertension
NFE2/Nrf2 repression to steatosis Lyle Burgoon
  • NFE2/Nrf2 repression
  • Increased, steatosis
NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon
  • Reduced, PTGS1 function
  • Activated, gastric ulcer formation
NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon
  • Reduced, PTGS2 function
  • Activated, gastric ulcer formation
presynaptic neuron 1 activation to epilepsy Lyle Burgoon
  • Activated, presynaptic neuron 1
  • Increased, epilepsy
presynaptic neuron 2 repression to epilepsy Lyle Burgoon
  • Reduced, presynaptic neuron 2 activity
  • Increased, epilepsy
Serotonin transporter activation to agitation Lyle Burgoon
  • Increased, agitation
Serotonin transporter activation to depression Lyle Burgoon
  • Increased, serotonin transporter activity
  • Increased, depression
Serotonin transporter activation to seizure Lyle Burgoon
  • Increased, serotonin transporter activity
  • Increased, seizure
SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon
  • Decreased, serotonin transporter activity
  • Increase, hypertension

Not under active development

Title Point of Contact MIE AO
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière
  • CYP7B activity, inhibition
  • Decrease, Population growth rate
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière
  • CYP7B activity, inhibition
  • Decrease, Population growth rate
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Michelle Embry
LXR activation leading to hepatic steatosis Marina Goumenou
  • Activation, LXR
  • peroxisome proliferator activated receptor promoter demethylation
  • N/A, Liver Steatosis
Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Timothy Allen
  • Mu Opioid Receptor Agonism
  • Analgesia
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen
  • Mu Opioid Receptor Agonism
  • Analgesia
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Timothy Allen
  • Serotonin 1A Receptor Agonism
  • Anti-depressant Activity
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Timothy Allen
  • Serotonin 1A Receptor Agonism
  • Anti-depressant Activity

Under development: Not open for comment. Do not cite

Title Point of Contact MIE AO
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi
  • Reproductive failure
Deposition of energy leading to population decline via DNA oxidation and follicular atresia You Song
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
Deposition of energy leading to population decline via DNA strand breaks and follicular atresia Knut Erik Tollefsen
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
DNA Adducts Leading to Liver Hemangiosarcoma Annie Jarabek
ER mediated breast cancer AOP Molly M Morgan
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen
  • Activation, Glutamate-gated chloride channels
  • Increased Mortality
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen
  • Activation, ionotropic GABA Receptor chloride channel
  • Increased Mortality
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi
  • Reproductive failure
Mitochondrial ATP synthase antagonism leading to growth inhibition (1) You Song
  • Increase, Mitochondrial ATP synthase antagonism
  • Decrease, Growth
Mitochondrial ATP synthase antagonism leading to growth inhibition (2) You Song
  • Increase, Mitochondrial ATP synthase antagonism
  • Decrease, Growth
Mitochondrial complex III antagonism leading to growth inhibition (1) You Song
  • Increase, Mitochondrial complex III antagonism
  • Decrease, Growth
Mitochondrial complex III antagonism leading to growth inhibition (2) You Song
  • Increase, Mitochondrial complex III antagonism
  • Decrease, Growth
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Jinhee Choi
  • Activation, NADPH Oxidase
  • Reproductive failure
Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Annie Jarabek
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi
  • Hepatotoxicity
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Jeanelle Martinez
  • TRPA1 activation, TRPA1 Receptor
  • Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
  • Irritation of nasal mucosa inducing sneeze reflex
  • Increased Respiratory irritability and Chronic Cough,

Under Development: Contributions and Comments Welcome

Title Point of Contact MIE AO
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Kellie Fay
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increase, predation
  • Decrease, Population growth rate
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increased, Population
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Kellie Fay
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Decreased, Reproductive Success
  • Decrease, Population growth rate
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Kellie Fay
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increased, Reproductive Success
  • Increased, Population
AhR activation leading to hepatic steatosis Michelle Angrish
  • Activation, AhR
  • Accumulation, Liver lipid
AKT2 activation leading to hepatic steatosis Michelle Angrish
  • systemic inflammation leading to hepatic steatosis
  • Increased, Liver Steatosis
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Tammy Stoker
  • Inhibition, Antgonism of NE receptor
  • Decreased, Decreased fecundity
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood
  • Increased, Binding of chemicals to 2u (serum)
  • Increase, Adenomas/carcinomas (renal tubular)
Altered ion channel activity leading impaired heart function Kevin Dreher
  • impaired, ion channels
  • Increased Mortality
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Charles Wood
  • Increased, Adenomas/carcinomas (mammary)
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Charles Wood
  • Promotion, ovarian adenomas
  • Promotion, ovarian granular cell tumors
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Tammy Stoker
  • Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
  • Decreased fertility, Reduced number of oocytes ovulated
Axonal sodium channel modulation leading to acute mortality Kellie Fay
  • modulation, sodium channel
  • Increased Mortality
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Charles Wood
  • Activation, beta-2 adrenergic receptor
  • Promotion, mesovarian leiomyomas
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood
  • Increase, Cytotoxicity (hepatocytes)
  • Increase, hepatocellular adenomas and carcinomas
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Charles Wood
  • Increased, mesotheliomas
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Kellie Fay
  • Inhibition, Cyclooxygenase 1 activity
  • Increased Mortality
  • Decrease, Population growth rate
Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve
  • Inhibition, Cyclooxygenase activity
  • N/A, Reproductive failure
Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Dalma Martinovic-Weigelt
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood
  • Increase, Cytotoxicity (club cells)
  • Increase, Adenomas/carcinomas (bronchioloalveolar)
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood
  • Increase, Cytotoxicity (tubular epithelial cells)
  • Increase, Adenomas/carcinomas (renal tubular)
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Charles Wood
  • Decreased, Androgen receptor activity
  • Increase, Leydig cell tumors
DNA methyltransferase inhibition leading to population decline (1) You Song
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
DNA methyltransferase inhibition leading to population decline (2) You Song
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
DNA methyltransferase inhibition leading to population decline (4) You Song
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
DNA methyltransferase inhibition leading to transgenerational effects (1) You Song
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity (F3)
  • Decrease, Population growth rate
DNA methyltransferase inhibition leading to transgenerational effects (2) You Song
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity (F3)
  • Decrease, Population growth rate
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman
  • Inhibition, Dual oxidase
  • Altered, Amphibian metamorphosis
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Charles Wood
  • prepubertal increase, Estrogen receptor (ER) activity
  • Increased, adenosquamous carcinomas of endometrium
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Charles Wood
  • Increase, Adenomas/carcinomas (follicular cell)
Epigenetic modification of PPARG leading to adipogenesis Michelle Angrish
  • peroxisome proliferator activated receptor promoter demethylation
  • chronic high fat diet
  • obesity
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood
  • Increase, Cytotoxicity (epithelial cells)
  • Increase, Papillomas/carcinomas (squamous cells)
ER agonism leading to reduced survival due to renal failure Tom Hutchinson
  • Agonism, Estrogen receptor
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Tom Hutchinson
  • Agonism, Estrogen receptor
  • skewed, sex ratio
Estrogen Receptor Activation and Female Precocious Puberty Jeff Welch
Estrogen receptor agonism leading to reproductive dysfunction Tom Hutchinson
  • Agonism, Estrogen receptor
  • Decrease, Population growth rate
  • Altered, Reproductive behaviour
  • Altered, Larval development
  • Impaired development of, Reproductive organs
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Kellie Fay
  • Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
  • Reduced, survival
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Susan Laws
  • Glucocorticoid Receptor Agonist, Activation
  • impaired, Fertility
Glutamate-gated chloride channel activation leading to acute mortality Helen Poynton
  • Activation, Glutamate-gated chloride channel
  • Increased Mortality
  • Decreased, population 1
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Charles Wood
  • Increased, Adenomas/carcinomas (mammary)
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Charles Wood
  • Increased, adenomas (pituitary)
Handbook development AOP Dan Villeneuve
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman
  • Activation, Hepatic nuclear receptor(s)
  • Altered, Amphibian metamorphosis
Histamine (H2) receptor antagonism leading to reduced survival Kellie Fay
  • Antagonism, Histamine Receptor (H2)
  • Decreased, survival
  • Increased, predation
HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay
  • Inhibition, HMG-CoA reductase
  • Decrease, Fertility
HNF4alpha suppression leading to hepatic steatosis Michelle Angrish
  • Suppression, HNF4alpha
HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood
  • Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
  • Increase, Papillomas/carcinomas (squamous cells)
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood
  • Increase, Dopaminergic activity
  • Increase, Endometrial adenocarcinomas
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood
  • Inhibition, 5α-reductase activity
  • Increase, Leydig cell tumors
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood
  • Inhibition, Na+/I- symporter (NIS)
  • Increase, Adenomas/carcinomas (follicular cell)
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood
  • Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
  • Increase, hepatocellular adenomas and carcinomas
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood
  • Thyroperoxidase, Inhibition
  • Increase, Adenomas/carcinomas (follicular cell)
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman
  • Inhibition, Iodotyrosine deiodinase (IYD)
  • Altered, Amphibian metamorphosis
Juvenile hormone receptor agonism leading to male offspring induction associated population decline Knut Erik Tollefsen
  • Activation, Juvenile hormone receptor
  • Increased, Male offspring
  • Decline, Population
  • Alteration, Food-web structures
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Gary Klinefelter
  • Decreased testosterone by the fetal Leydig cells, Increased corticosterone
  • Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
  • Decreased sperm quantity / quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Gary Klinefelter
  • Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
  • Decreased sperm quantity / quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Gary Klinefelter
  • Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol
  • Decreased Cholesterol, Decreased Uptake of Lipoproteins
  • Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
  • Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Gary Klinefelter
  • Decreased testosterone by the fetal Leydig cells, Increased estradiol
  • Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists
  • Decreased sperm quantity / quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Gary Klinefelter
  • Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
  • Decreased sperm quantity or quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Gary Klinefelter
  • Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
  • Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Gary Klinefelter
  • Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
  • Decreased sperm quantity or quality in the adult, Decreased fertility
NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish
  • Activation, NRF2
  • Activation, NR1H4
  • Increased, Liver Steatosis
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Carlie LaLone
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
Nosema infection causes abnormal role change that leads to colony loss/failure Carlie LaLone
  • Death/Failure, Colony
Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone
  • Death/Failure, Colony
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish
  • Activation, PXR/SXR
  • Increased, Liver Steatosis
NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish
  • Suppression, Constitutive androstane receptor, NR1l3
  • Inhibition, PPAR alpha
  • Activation, LXR
  • peroxisome proliferator activated receptor promoter demethylation
  • Increased, Liver Steatosis
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay
  • Inhibition, organic anion transporter 1 (OAT1)
  • Increased Mortality
  • Decrease, Population growth rate
Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman
  • Inhibition, Pendrin
  • Altered, Amphibian metamorphosis
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish
  • Decreased, PPAR-alpha activation
  • Decreased, PPAR-beta activation
  • Decreased, PPAR-gamma activation
  • Increased, Liver Steatosis
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Charles Wood
  • Increased, Pancreatic acinar tumors
PPARgamma activation leading to sarcomas in rats, mice, and hamsters Charles Wood
  • Activation of specific nuclear receptors, PPAR-gamma activation
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt
  • Inhibition, Prolyl hydroxylases
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
Queen egg-laying decrease leads to colony loss/failure Carlie LaLone
  • Death/Failure, Colony
Sodium channel (Nav1.1) inhibition leading to population decline Kellie Fay
  • Inhibition, sodium channel
Sodium channel inhibition leading to congenital malformations Kellie Fay
  • Inhibition, sodium channel
  • Increased, amputations
sodium channel inhibition leading to increased predation Kellie Fay
  • Inhibition, sodium channel
  • Increased, predation
Sodium channel inhibition leading to reduced survival Kellie Fay
  • Inhibition, sodium channel
  • Reduced, feeding 1
  • Increased, predation
  • Reduced, survival
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert
  • Inhibition, Na+/I- symporter (NIS)
  • Cognitive Function, Decreased
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Jonathan Haselman
  • Inhibition, Na+/I- symporter (NIS)
  • Altered, Amphibian metamorphosis
Thyroperoxidase inhibition leading to altered amphibian metamorphosis Jonathan Haselman
  • Thyroperoxidase, Inhibition
  • Altered, Amphibian metamorphosis
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman
  • Inhibition, Deiodinase 1
  • Altered, Amphibian metamorphosis
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman
  • Inhibition, Deiodinase 2
  • Altered, Amphibian metamorphosis
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman
  • Inhibition, Deiodinase 3
  • Altered, Amphibian metamorphosis
unknown MIE leading to renal failure and mortality Kellie Fay
  • Unknown, MIE
  • Increased Mortality
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt
  • modulation, Unknown
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood
  • Increase, Urinary bladder calculi
  • Increase, Adenomas/carcinomas (urothelial)
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Carlie LaLone
  • Death/Failure, Colony
Varroa mite infestation increases virus levels leading to colony loss/failure Carlie LaLone
  • Death/Failure, Colony
Weather event contributes abnormal foraging leading to colony loss/failure Carlie LaLone
  • Death/Failure, Colony
Weather event contributes to colony loss/failure Carlie LaLone
  • Death/Failure, Colony
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Tammy Stoker
  • Inhibition, Inhibition of Dopamine-beta-hydroxylase
  • Decreased, Decreased fecundity