AOPs With SAAOP Status

Under Development

Open for citation & comment

Title Point of Contact MIE AO
Ecdysone receptor agonism leading to incomplete ecdysis associated mortality Knut Erik Tollefsen 103: Increase, Ecdysone receptor agonism

Open for comment. Do not cite

Title Point of Contact MIE AO
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Carlie LaLone 566: impaired, Larval development and 563: Death/Failure, Colony
AOP from chemical insult to cell death Mathieu Vinken 1258: Decompartmentalization and 1260: Direct mitochondrial inhibition and 1259: narcosis 1262: Apoptosis and 1263: Necrosis
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Carlie LaLone 566: impaired, Larval development and 563: Death/Failure, Colony
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone 572: Decrease, Number of worker bees and 563: Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Carlie LaLone 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Carlie LaLone 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Carlie LaLone 559: Activation, Nicotinic acetylcholine receptor 566: impaired, Larval development and 563: Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Carlie LaLone 559: Activation, Nicotinic acetylcholine receptor 566: impaired, Larval development and 563: Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Carlie LaLone 559: Activation, Nicotinic acetylcholine receptor 572: Decrease, Number of worker bees and 568: impaired, Hive thermoregulation and 563: Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Carlie LaLone 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Carlie LaLone 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone 572: Decrease, Number of worker bees and 563: Death/Failure, Colony
Suppression of immune system contributes to impaired development and leads to colony loss/failure Carlie LaLone 572: Decrease, Number of worker bees and 568: impaired, Hive thermoregulation and 563: Death/Failure, Colony

Open for adoption

Title Point of Contact MIE AO
Alkylation of DNA leading to cancer 1 Carole Yauk 97: Alkylation, DNA 885: Increase, Cancer
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel 27: N/A, Androgen receptor, Antagonism 337: N/A, Impairment of reproductive capacity
Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon 51: Inhibition, Ca++ ATPase 356: Increased, Oxidative damage
Estrogen receptor activation leading to breast cancer Molly M Morgan 1181: Activation, Estrogen receptor 1193: N/A, Breast Cancer
Gastric ulcer formation Lyle Burgoon 1367: Inhibit, gastric ulcer formation and 1385: Activated, gastric ulcer formation
Helicobacter pylori to gastric ulcer Lyle Burgoon 1412: Helicobacter pylori infection 1385: Activated, gastric ulcer formation
Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon 1490: Inhibition, Fatty Acid Beta Oxidation 1489: N/A, Steatohepatisis
Kidney toxicity induced by activation of 5HT2C Kevin Crofton 9: Activation, 5HT2c 759: Increased, Kidney Failure
Mental stress to agitation Lyle Burgoon 1396: Increased, glucocorticoid receptor activity 1345: Increased, agitation
Mental stress to depression Lyle Burgoon 1396: Increased, glucocorticoid receptor activity 1346: Increased, depression
Molecular events lead to epilepsy Lyle Burgoon 1348: Increase, seizure and 1362: Increased, hippocampal hyperdepolarization and 1363: Increased, epilepsy
Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon 1344: Increased, seizure and 1345: Increased, agitation and 1346: Increased, depression and 1343: Increase, hypertension
NFE2/Nrf2 repression to steatosis Lyle Burgoon 1417: NFE2/Nrf2 repression 1418: Increased, steatosis
NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon 1402: Reduced, PTGS1 function 1385: Activated, gastric ulcer formation
NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon 1408: Reduced, PTGS2 function 1385: Activated, gastric ulcer formation
presynaptic neuron 1 activation to epilepsy Lyle Burgoon 1349: Activated, presynaptic neuron 1 1363: Increased, epilepsy
presynaptic neuron 2 repression to epilepsy Lyle Burgoon 1413: Reduced, presynaptic neuron 2 activity 1363: Increased, epilepsy
Serotonin transporter activation to agitation Lyle Burgoon 1345: Increased, agitation
Serotonin transporter activation to depression Lyle Burgoon 1397: Increased, serotonin transporter activity 1346: Increased, depression
Serotonin transporter activation to seizure Lyle Burgoon 1397: Increased, serotonin transporter activity 1344: Increased, seizure
SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon 1317: Decreased, serotonin transporter activity 1343: Increase, hypertension

Not under active development

Title Point of Contact MIE AO
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière 1386: CYP7B activity, inhibition 442: Decreased, Population trajectory
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière 1386: CYP7B activity, inhibition 442: Decreased, Population trajectory
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Michelle Embry
LXR activation leading to hepatic steatosis Marina Goumenou 167: Activation, LXR and 228: peroxisome proliferator activated receptor promoter demethylation 345: N/A, Liver Steatosis
Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Timothy Allen 1425: Mu Opioid Receptor Agonism 1428: Analgesia
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen 1425: Mu Opioid Receptor Agonism 1428: Analgesia
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Timothy Allen 1431: Serotonin 1A Receptor Agonism 1432: Anti-depressant Activity
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Timothy Allen 1431: Serotonin 1A Receptor Agonism 1432: Anti-depressant Activity

Under development: Not open for comment. Do not cite

Title Point of Contact MIE AO
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi 1277: Reproductive failure
DNA Adducts Leading to Liver Hemangiosarcoma Annie Jarabek
ER mediated breast cancer AOP Molly M Morgan
Excessive reactive oxygen species production leading to population decline via follicular atresia Knut Erik Tollefsen 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Excessive reactive oxygen species production leading to population decline via reduced fatty acid beta-oxidation You Song 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen 1018: Activation, Glutamate-gated chloride channels 351: Increased Mortality
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen 762: Activation, ionotropic GABA Receptor chloride channel 351: Increased Mortality
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi 1277: Reproductive failure
Juvenile hormone receptor agonism leading to male offspring induction associated population decline Knut Erik Tollefsen 1205: Activation, Juvenile hormone receptor 1208: Increased, Male offspring and 361: Decline, Population and 1210: Alteration, Food-web structures
Mitochondrial ATP synthase antagonism leading to growth inhibition (1) You Song 1785: Increase, Mitochondrial ATP synthase antagonism 1521: Decrease, Growth
Mitochondrial ATP synthase antagonism leading to growth inhibition (2) You Song 1785: Increase, Mitochondrial ATP synthase antagonism 1521: Decrease, Growth
Mitochondrial complex III antagonism leading to growth inhibition (1) You Song 1542: Increase, Mitochondrial complex III antagonism 1521: Decrease, Growth
Mitochondrial complex III antagonism leading to growth inhibition (2) You Song 1542: Increase, Mitochondrial complex III antagonism 1521: Decrease, Growth
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Jinhee Choi 1174: Activation, NADPH Oxidase 1277: Reproductive failure
Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Annie Jarabek
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi 1291: Hepatotoxicity
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Jeanelle Martinez 1215: TRPA1 activation, TRPA1 Receptor 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea and 1434: Irritation of nasal mucosa inducing sneeze reflex and 1226: Increased Respiratory irritability and Chronic Cough,

Under Development: Contributions and Comments Welcome

Title Point of Contact MIE AO
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Kellie Fay 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 623: Increase, predation and 361: Decline, Population
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1164: Increased, Population
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Kellie Fay 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1141: Decreased, Reproductive Success and 361: Decline, Population
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Kellie Fay 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1163: Increased, Reproductive Success and 1164: Increased, Population
AhR activation leading to hepatic steatosis Michelle Angrish 18: Activation, AhR 455: Accumulation, Liver lipid
AKT2 activation leading to hepatic steatosis Michelle Angrish 486: systemic inflammation leading to hepatic steatosis 459: Increased, Liver Steatosis
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Tammy Stoker 849: Inhibition, Antgonism of NE receptor 527: Decreased, Decreased fecundity
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood 714: Increased, Binding of chemicals to 2u (serum) 713: Increase, Adenomas/carcinomas (renal tubular)
Altered ion channel activity leading impaired heart function Kevin Dreher 697: impaired, ion channels 351: Increased Mortality
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Charles Wood 1079: Increased, Adenomas/carcinomas (mammary)
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Charles Wood 1053: Promotion, ovarian adenomas and 1054: Promotion, ovarian granular cell tumors
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Tammy Stoker 964: Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol 972: Decreased fertility, Reduced number of oocytes ovulated
Axonal sodium channel modulation leading to acute mortality Kellie Fay 598: modulation, sodium channel 351: Increased Mortality
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Charles Wood 1038: Activation, beta-2 adrenergic receptor 1044: Promotion, mesovarian leiomyomas
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood 786: Increase, Cytotoxicity (hepatocytes) 719: Increase, hepatocellular adenomas and carcinomas
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Charles Wood 1090: Increased, mesotheliomas
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Kellie Fay 1103: Inhibition, Cyclooxygenase 1 activity 351: Increased Mortality and 361: Decline, Population
Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve 79: Inhibition, Cyclooxygenase activity 253: N/A, Reproductive failure
Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Dalma Martinovic-Weigelt 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood 770: Increase, Cytotoxicity (club cells) 736: Increase, Adenomas/carcinomas (bronchioloalveolar)
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood 783: Increase, Cytotoxicity (tubular epithelial cells) 713: Increase, Adenomas/carcinomas (renal tubular)
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Charles Wood 742: Decreased, Androgen receptor activity 745: Increase, Leydig cell tumors
DNA methyltransferase inhibition leading to population decline (1) You Song 1619: Increase, DNA methyltransferase inhibition 328: Decrease, Fecundity and 360: Decrease, Population trajectory
DNA methyltransferase inhibition leading to population decline (2) You Song 1619: Increase, DNA methyltransferase inhibition 328: Decrease, Fecundity and 360: Decrease, Population trajectory
DNA methyltransferase inhibition leading to population decline (4) You Song 1619: Increase, DNA methyltransferase inhibition 328: Decrease, Fecundity and 360: Decrease, Population trajectory
DNA methyltransferase inhibition leading to transgenerational effects (1) You Song 1619: Increase, DNA methyltransferase inhibition 1781: Decrease, Fecundity (F3) and 360: Decrease, Population trajectory
DNA methyltransferase inhibition leading to transgenerational effects (2) You Song 1619: Increase, DNA methyltransferase inhibition 1781: Decrease, Fecundity (F3) and 360: Decrease, Population trajectory
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman 1156: Inhibition, Dual oxidase 1101: Altered, Amphibian metamorphosis
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Charles Wood 1064: prepubertal increase, Estrogen receptor (ER) activity 1070: Increased, adenosquamous carcinomas of endometrium
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Charles Wood 1026: Increased Apoptosis, Adenomas/carcinomas (follicular cell)
Epigenetic modification of PPARG leading to adipogenesis Michelle Angrish 228: peroxisome proliferator activated receptor promoter demethylation and 1454: chronic high fat diet 1447: obesity
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood 780: Increase, Cytotoxicity (epithelial cells) 779: Increase, Papillomas/carcinomas (squamous cells)
ER agonism leading to reduced survival due to renal failure Tom Hutchinson 111: Agonism, Estrogen receptor
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Tom Hutchinson 111: Agonism, Estrogen receptor 417: skewed, sex ratio
Estrogen Receptor Activation and Female Precocious Puberty Jeff Welch
Estrogen receptor agonism leading to reproductive dysfunction Tom Hutchinson 111: Agonism, Estrogen receptor 360: Decrease, Population trajectory and 363: Altered, Reproductive behaviour and 339: Altered, Larval development and 364: Impaired development of, Reproductive organs
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Kellie Fay 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel 592: Reduced, survival
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Susan Laws 494: Glucocorticoid Receptor Agonist, Activation 406: impaired, Fertility
Glutamate-gated chloride channel activation leading to acute mortality Kellie Fay 760: Activation, Glutamate-gated chloride channel 351: Increased Mortality and 765: Decreased, population 1
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Charles Wood 1079: Increased, Adenomas/carcinomas (mammary)
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Charles Wood 1082: Increased, adenomas (pituitary)
Handbook development AOP Dan Villeneuve
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman 1157: Activation, Hepatic nuclear receptor(s) 1101: Altered, Amphibian metamorphosis
Histamine (H2) receptor antagonism leading to reduced survival Kellie Fay 638: Antagonism, Histamine Receptor (H2) 636: Decreased, survival and 588: Increased, predation
HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay 804: Inhibition, HMG-CoA reductase 330: Decrease, Fertility
HNF4alpha suppression leading to hepatic steatosis Michelle Angrish 461: Suppression, HNF4alpha
HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood 766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme 779: Increase, Papillomas/carcinomas (squamous cells)
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood 746: Increase, Dopaminergic activity 773: Increase, Endometrial adenocarcinomas
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood 790: Inhibition, 5α-reductase activity 745: Increase, Leydig cell tumors
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood 737: Decreased, Uptake of inorganic iodide 741: Increase, Adenomas/carcinomas (follicular cell)
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood 724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme 719: Increase, hepatocellular adenomas and carcinomas
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood 279: Thyroperoxidase, Inhibition 741: Increase, Adenomas/carcinomas (follicular cell)
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman 1152: Inhibition, Iodotyrosine deiodinase (IYD) 1101: Altered, Amphibian metamorphosis
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Gary Klinefelter 653: Decreased testosterone by the fetal Leydig cells, Increased corticosterone and 654: Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists 505: Decreased sperm quantity / quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Gary Klinefelter 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome 505: Decreased sperm quantity / quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Gary Klinefelter 642: Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol and 643: Decreased Cholesterol, Decreased Uptake of Lipoproteins and 644: Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane 646: Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Gary Klinefelter 658: Decreased testosterone by the fetal Leydig cells, Increased estradiol and 659: Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists 505: Decreased sperm quantity / quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Gary Klinefelter 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid 520: Decreased sperm quantity or quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Gary Klinefelter 662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis 543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Gary Klinefelter 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell 520: Decreased sperm quantity or quality in the adult, Decreased fertility
NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish 478: Activation, NRF2 and 479: Activation, NR1H4 459: Increased, Liver Steatosis
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Carlie LaLone 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
Nosema infection causes abnormal role change that leads to colony loss/failure Carlie LaLone 563: Death/Failure, Colony
Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone 563: Death/Failure, Colony
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish 245: Activation, PXR/SXR 459: Increased, Liver Steatosis
NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish 456: Suppression, Constitutive androstane receptor, NR1l3 and 468: Inhibition, PPAR alpha and 167: Activation, LXR and 228: peroxisome proliferator activated receptor promoter demethylation 459: Increased, Liver Steatosis
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay 877: Inhibition, organic anion transporter 1 (OAT1) 351: Increased Mortality and 361: Decline, Population
Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman 1155: Inhibition, Pendrin 1101: Altered, Amphibian metamorphosis
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish 231: Decreased, PPAR-alpha activation and 232: Decreased, PPAR-beta activation and 233: Decreased, PPAR-gamma activation 459: Increased, Liver Steatosis
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Charles Wood 1063: Increased, Pancreatic acinar tumors
PPARgamma activation leading to sarcomas in rats, mice, and hamsters Charles Wood 1028: Activation of specific nuclear receptors, PPAR-gamma activation
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt 798: Inhibition, Prolyl hydroxylases 78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory
Queen egg-laying decrease leads to colony loss/failure Carlie LaLone 563: Death/Failure, Colony
Sodium channel (Nav1.1) inhibition leading to population decline Kellie Fay 584: Inhibition, sodium channel
Sodium channel inhibition leading to congenital malformations Kellie Fay 584: Inhibition, sodium channel 591: Increased, amputations
sodium channel inhibition leading to increased predation Kellie Fay 584: Inhibition, sodium channel 588: Increased, predation
Sodium channel inhibition leading to reduced survival Kellie Fay 584: Inhibition, sodium channel 587: Reduced, feeding 1 and 588: Increased, predation and 592: Reduced, survival
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert 424: Inhibition, Na+/I- symporter (NIS) 402: Cognitive Function, Decreased
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Jonathan Haselman 424: Inhibition, Na+/I- symporter (NIS) 1101: Altered, Amphibian metamorphosis
Thyroperoxidase inhibition leading to altered amphibian metamorphosis Jonathan Haselman 279: Thyroperoxidase, Inhibition 1101: Altered, Amphibian metamorphosis
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman 1009: Inhibition, Deiodinase 1 1101: Altered, Amphibian metamorphosis
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman 1002: Inhibition, Deiodinase 2 1101: Altered, Amphibian metamorphosis
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman 1153: Inhibition, Deiodinase 3 1101: Altered, Amphibian metamorphosis
unknown MIE leading to renal failure and mortality Kellie Fay 1114: Unknown, MIE 351: Increased Mortality
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt 801: modulation, Unknown 78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood 793: Increase, Urinary bladder calculi 797: Increase, Adenomas/carcinomas (urothelial)
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Carlie LaLone 563: Death/Failure, Colony
Varroa mite infestation increases virus levels leading to colony loss/failure Carlie LaLone 563: Death/Failure, Colony
Weather event contributes abnormal foraging leading to colony loss/failure Carlie LaLone 563: Death/Failure, Colony
Weather event contributes to colony loss/failure Carlie LaLone 563: Death/Failure, Colony
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Tammy Stoker 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase 527: Decreased, Decreased fecundity