AOPs With SAAOP Status


Under Development

Open for citation & comment

Title Point of Contact MIE AO
Ecdysone receptor agonism leading to incomplete ecdysis associated mortality Knut Erik Tollefsen EcR mortality

Open for comment. Do not cite

Title Point of Contact MIE AO
AOP from chemical insult to cell death Mathieu Vinken

Under development: Not open for comment. Do not cite

Title Point of Contact MIE AO
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh 5-HTT increased predation
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Kellie Fay 5-HTT increased predation
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Kellie Fay
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Kellie Fay
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Carlie LaLone unk colony loss/failure
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi
AhR activation leading to hepatic steatosis Michelle Angrish AhR hepatic steatosis
AKT2 activation leading to hepatic steatosis Michelle Angrish AKT2 hepatic steatosis
Alkylation of DNA leading to cancer 1 Carole Yauk DNA alkylation cancer
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Tammy Stoker alpha Norad Receptors delayed ovulation
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood Alpha2u adenomas and carcinomas
Altered ion channel activity leading impaired heart function Kevin Dreher multiple impaired heart function
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel AR adverse effects in the male foetus
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Charles Wood
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Charles Wood
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Tammy Stoker
Axonal sodium channel modulation leading to acute mortality Kellie Fay sodium channel acute mortality
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Charles Wood
Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon unclear energy imbalance
Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti tubulin? aneuploid offspring
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood cytotox is not MIE hepatocellular adenomas and carcinomas
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Charles Wood
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Kellie Fay
Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve cyclooxygenase reproductive failure
Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt cyclooxygenase reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Dalma Martinovic-Weigelt cyclooxygenase reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt cyclooxygenase reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt cyclooxygenase reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt cyclooxygenase reproductive dysfunction
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood cytotox is not MIE bronchioloalveolar adenomas and carcinomas
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood cytotox is not MIE renal tubular adenomas and carcinomas
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Carlie LaLone glucose oxidase colony loss/failure
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Charles Wood AR leydig cell tumors
DNA Adducts Leading to Liver Hemangiosarcoma Annie Jarabek
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Charles Wood
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Charles Wood
Epigenetic modification of PPARG leading to adipogenesis Michelle Angrish PPARg adipogenesis
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood cytotox not MIE forestomach tumors
ER agonism leading to reduced survival due to renal failure Tom Hutchinson ER reduced survival
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Tom Hutchinson ER altered sexual differentiation
ER mediated breast cancer AOP Molly M Morgan
Estrogen Receptor Activation and Female Precocious Puberty Jeff Welch ER
Estrogen receptor activation leading to breast cancer Molly M Morgan
Estrogen receptor agonism leading to reproductive dysfunction Tom Hutchinson ER reproductive dysfunction
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Kellie Fay ERG reduced survival
Excessive reactive oxygen species production leading to oocyte apoptosis-associated reproduction decline Knut Erik Tollefsen
Gastric ulcer formation Lyle Burgoon
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Susan Laws GR decreased male fertitlity
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone GR increased disease susceptibility
Glutamate-gated chloride channel activation leading to acute mortality Kellie Fay GluCl Channel acute mortality
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Charles Wood
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Charles Wood
Handbook development AOP Dan Villeneuve
Helicobacter pylori to gastric ulcer Lyle Burgoon
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman
Histamine (H2) receptor antagonism leading to reduced survival Kellie Fay H2 reduced survival
HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay HMG-CoA reductase decreased fertility
HNF4alpha suppression leading to hepatic steatosis Michelle Angrish HNF4alpha hepatic steatosis
HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood HPPD corneal papillomas and carcinomas
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood dopamine?? endometrial adenocarcinomas
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone metabolic stress is not MIE colony loss/failure
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood 5α-reductase leydig cell tumors
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière
Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Michelle Embry nitric oxide liver tumors
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood NIS follicular cell adenomas and carcinomas
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood pyruvate dehydrogenase hepatocellular carcinoma
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood TPO follicular cell adenomas and carcinomas
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi
Juvenile hormone receptor agonism leading to male offspring induction associated population decline Knut Erik Tollefsen
Kidney toxicity induced by activation of 5HT2C Kevin Crofton 5-HTT2c kidney toxicity
LXR activation leading to hepatic steatosis Marina Goumenou LXR liver steatosis
Mental stress to agitation Lyle Burgoon
Mental stress to depression Lyle Burgoon
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Gary Klinefelter GR modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Gary Klinefelter proteins - undefined modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Gary Klinefelter multiple modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Gary Klinefelter estradiol modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Gary Klinefelter GR modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Gary Klinefelter unk modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Gary Klinefelter modulation of leydig cell function
Molecular events lead to epilepsy Lyle Burgoon
Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Timothy Allen
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Jinhee Choi
Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon
NFE2/Nrf2 repression to steatosis Lyle Burgoon
NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish multiple hepatic steatosis
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Carlie LaLone nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Carlie LaLone nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Carlie LaLone nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Carlie LaLone nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Carlie LaLone nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Carlie LaLone nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Carlie LaLone
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Carlie LaLone nAChR colony loss/failure
Nosema infection causes abnormal role change that leads to colony loss/failure Carlie LaLone
Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish PXR hepatic steatosis
NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish CAR hepatic steatosis
NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon
NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay p-amino hippuric acid renal failure and mortality
Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Annie Jarabek
Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish b-oxidation fatty acid steatosis
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Charles Wood
PPARgamma activation leading to sarcomas in rats, mice, and hamsters Charles Wood
presynaptic neuron 1 activation to epilepsy Lyle Burgoon
presynaptic neuron 2 repression to epilepsy Lyle Burgoon
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt Prolyl hydroxylase reproductive dysfunction
Queen egg-laying decrease leads to colony loss/failure Carlie LaLone
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Timothy Allen
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Timothy Allen
Serotonin transporter activation to agitation Lyle Burgoon
Serotonin transporter activation to depression Lyle Burgoon
Serotonin transporter activation to seizure Lyle Burgoon
Sodium channel (Nav1.1) inhibition leading to population decline Kellie Fay
Sodium channel inhibition leading to congenital malformations Kellie Fay sodium channel congenital malformations
sodium channel inhibition leading to increased predation Kellie Fay sodium channel increased predation
Sodium channel inhibition leading to reduced survival Kellie Fay sodium channel reduced survival
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert NIS neurodevelopmental outcomes
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Jonathan Haselman
SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone unclear colony loss/failure
Suppression of immune system contributes to impaired development and leads to colony loss/failure Carlie LaLone unclear colony loss/failure
Thyroperoxidase inhibition leading to altered amphibian metamorphosis Jonathan Haselman
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman
unknown MIE leading to renal failure and mortality Kellie Fay
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt Unknown reproductive dysfunction
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood unclear urothelial papillomas and carcinomas
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Carlie LaLone
Varroa mite infestation increases virus levels leading to colony loss/failure Carlie LaLone
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Jeanelle Martinez
Weather event contributes abnormal foraging leading to colony loss/failure Carlie LaLone
Weather event contributes to colony loss/failure Carlie LaLone
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Tammy Stoker DBH reduced fecundity