AOPs With SAAOP Status

Under Development

Open for citation & comment

Title	Point of Contact	MIE	AO
Ecdysone receptor agonism leading to incomplete ecdysis associated mortality	Knut Erik Tollefsen	EcR	mortality

Open for comment. Do not cite

Title	Point of Contact	MIE	AO
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure	Carlie LaLone	unk	colony loss/failure
AOP from chemical insult to cell death	Mathieu Vinken
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure	Carlie LaLone	glucose oxidase	colony loss/failure
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure	Carlie LaLone	metabolic stress is not MIE	colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1	Carlie LaLone	nAChR	colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure	Carlie LaLone	nAChR	colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste	Carlie LaLone	nAChR	colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1	Carlie LaLone	nAChR	colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2	Carlie LaLone	nAChR	colony loss/failure
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure	Carlie LaLone	nAChR	colony loss/failure
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure	Carlie LaLone	nAChR	colony loss/failure
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure	Carlie LaLone	nAChR	colony loss/failure
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure	Carlie LaLone	unclear	colony loss/failure
Suppression of immune system contributes to impaired development and leads to colony loss/failure	Carlie LaLone	unclear	colony loss/failure
Uncoupling of oxidative phosphorylation leading to growth inhibition (1)	You Song

Open for adoption

Title	Point of Contact	MIE	AO
Alkylation of DNA leading to cancer 1	Carole Yauk	DNA alkylation	cancer
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)	Mukesh Patel	AR	adverse effects in the male foetus
Calcium-mediated neuronal ROS production and energy imbalance	Lyle Burgoon	unclear	energy imbalance
Estrogen receptor activation leading to breast cancer	Molly M Morgan
Gastric ulcer formation	Lyle Burgoon
Helicobacter pylori to gastric ulcer	Lyle Burgoon
Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)	Lyle Burgoon
Kidney toxicity induced by activation of 5HT2C	Kevin Crofton	5-HTT2c	kidney toxicity
Mental stress to agitation	Lyle Burgoon
Mental stress to depression	Lyle Burgoon
Molecular events lead to epilepsy	Lyle Burgoon
Network of SSRIs (selective serotonin reuptake inhibitors)	Lyle Burgoon
NFE2/Nrf2 repression to steatosis	Lyle Burgoon
NSAID induced PTGS1 inactivation to gastric ulcer	Lyle Burgoon
NSAID induced PTGS2 inactivation to gastric ulcer	Lyle Burgoon
presynaptic neuron 1 activation to epilepsy	Lyle Burgoon
presynaptic neuron 2 repression to epilepsy	Lyle Burgoon
Serotonin transporter activation to agitation	Lyle Burgoon
Serotonin transporter activation to depression	Lyle Burgoon
Serotonin transporter activation to seizure	Lyle Burgoon
SSRI (Selective serotonin reuptake inhibitor) to hypertension	Lyle Burgoon

Not under active development

Title	Point of Contact	MIE	AO
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity	Florence Pagé-Larivière
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior	Florence Pagé-Larivière
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors	Michelle Embry	nitric oxide	liver tumors
LXR activation leading to hepatic steatosis	Marina Goumenou	LXR	liver steatosis
Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition	Timothy Allen
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening	Timothy Allen
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition	Timothy Allen
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening	Timothy Allen

Under development: Not open for comment. Do not cite

Title	Point of Contact	MIE	AO
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building	Jinhee Choi
DNA Adducts Leading to Liver Hemangiosarcoma	Annie Jarabek
ER mediated breast cancer AOP	Molly M Morgan
Excessive reactive oxygen species production leading to population decline via follicular atresia	Knut Erik Tollefsen
Excessive reactive oxygen species production leading to population decline via reduced fatty acid beta-oxidation	You Song
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality	Knut Erik Tollefsen
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality	Knut Erik Tollefsen
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure	Jinhee Choi
Juvenile hormone receptor agonism leading to male offspring induction associated population decline	Knut Erik Tollefsen
Mitochondrial ATP synthase antagonism leading to growth inhibition (1)	You Song
Mitochondrial ATP synthase antagonism leading to growth inhibition (2)	You Song
Mitochondrial complex III antagonism leading to growth inhibition (1)	You Song
Mitochondrial complex III antagonism leading to growth inhibition (2)	You Song
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans	Jinhee Choi
Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling	Annie Jarabek
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP	Jinhee Choi
Uncoupling of oxidative phosphorylation leading to growth inhibition (2)	You Song
Uncoupling of oxidative phosphorylation leading to growth inhibition (3)	You Song
Uncoupling of oxidative phosphorylation leading to growth inhibition (4)	You Song
Uncoupling of oxidative phosphorylation leading to growth inhibition (5)	You Song
Uncoupling of oxidative phosphorylation leading to growth inhibition (6)	You Song
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation	Jeanelle Martinez

Under Development: Contributions and Comments Welcome

Title	Point of Contact	MIE	AO
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline	Kellie Fay	5-HTT	increased predation
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase	Kellie Fay
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline	Kellie Fay
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase	Kellie Fay
AhR activation leading to hepatic steatosis	Michelle Angrish	AhR	hepatic steatosis
AKT2 activation leading to hepatic steatosis	Michelle Angrish	AKT2	hepatic steatosis
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation	Tammy Stoker	alpha Norad Receptors	delayed ovulation
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)	Charles Wood	Alpha2u	adenomas and carcinomas
Altered ion channel activity leading impaired heart function	Kevin Dreher	multiple	impaired heart function
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat	Charles Wood
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse	Charles Wood
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats	Tammy Stoker
Axonal sodium channel modulation leading to acute mortality	Kellie Fay	sodium channel	acute mortality
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse	Charles Wood
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)	Charles Wood	cytotox is not MIE	hepatocellular adenomas and carcinomas
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.	Charles Wood
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality	Kellie Fay
Cyclooxygenase inhibition leading reproductive failure	Dan Villeneuve	cyclooxygenase	reproductive failure
Cyclooxygenase inhibition leading to reproductive dysfunction	Dalma Martinovic-Weigelt	cyclooxygenase	reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior	Dalma Martinovic-Weigelt	cyclooxygenase	reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release	Dalma Martinovic-Weigelt	cyclooxygenase	reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition	Dalma Martinovic-Weigelt	cyclooxygenase	reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint	Dalma Martinovic-Weigelt	cyclooxygenase	reproductive dysfunction
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)	Charles Wood	cytotox is not MIE	bronchioloalveolar adenomas and carcinomas
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)	Charles Wood	cytotox is not MIE	renal tubular adenomas and carcinomas
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)	Charles Wood	AR	leydig cell tumors
DNA methyltransferase inhibition leading to population decline (1)	You Song
DNA methyltransferase inhibition leading to population decline (2)	You Song
DNA methyltransferase inhibition leading to population decline (4)	You Song
DNA methyltransferase inhibition leading to transgenerational effects (1)	You Song
DNA methyltransferase inhibition leading to transgenerational effects (2)	You Song
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.	Charles Wood
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse	Charles Wood
Epigenetic modification of PPARG leading to adipogenesis	Michelle Angrish	PPARg	adipogenesis
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)	Charles Wood	cytotox not MIE	forestomach tumors
ER agonism leading to reduced survival due to renal failure	Tom Hutchinson	ER	reduced survival
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males	Tom Hutchinson	ER	altered sexual differentiation
Estrogen Receptor Activation and Female Precocious Puberty	Jeff Welch	ER
Estrogen receptor agonism leading to reproductive dysfunction	Tom Hutchinson	ER	reproductive dysfunction
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival	Kellie Fay	ERG	reduced survival
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility	Susan Laws	GR	decreased male fertitlity
Glutamate-gated chloride channel activation leading to acute mortality	Kellie Fay	GluCl Channel	acute mortality
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.	Charles Wood
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.	Charles Wood
Handbook development AOP	Dan Villeneuve
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis	Jonathan Haselman
Histamine (H2) receptor antagonism leading to reduced survival	Kellie Fay	H2	reduced survival
HMG-CoA reductase inhibition leading to decreased fertility	Kellie Fay	HMG-CoA reductase	decreased fertility
HNF4alpha suppression leading to hepatic steatosis	Michelle Angrish	HNF4alpha	hepatic steatosis
HPPD inhibition leading to corneal papillomas and carcinomas (in rat)	Charles Wood	HPPD	corneal papillomas and carcinomas
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)	Charles Wood	dopamine??	endometrial adenocarcinomas
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)	Charles Wood	5α-reductase	leydig cell tumors
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)	Charles Wood	NIS	follicular cell adenomas and carcinomas
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)	Charles Wood	pyruvate dehydrogenase	hepatocellular carcinoma
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)	Charles Wood	TPO	follicular cell adenomas and carcinomas
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis	Gary Klinefelter	GR	modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome	Gary Klinefelter	proteins - undefined	modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell	Gary Klinefelter	multiple	modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis	Gary Klinefelter	estradiol	modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation	Gary Klinefelter	GR	modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis	Gary Klinefelter	unk	modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell	Gary Klinefelter		modulation of leydig cell function
NFE2L2/FXR activation leading to hepatic steatosis	Michelle Angrish	multiple	hepatic steatosis
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure	Carlie LaLone
Nosema infection causes abnormal role change that leads to colony loss/failure	Carlie LaLone
Nosema infection increases energetic demands leading to colony loss/failure	Carlie LaLone
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis	Michelle Angrish	PXR	hepatic steatosis
NR1I3 (CAR) suppression leading to hepatic steatosis	Michelle Angrish	CAR	hepatic steatosis
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality	Kellie Fay	p-amino hippuric acid	renal failure and mortality
Pendrin inhibition leading to altered amphibian metamorphosis	Jonathan Haselman
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis	Michelle Angrish	b-oxidation fatty acid	steatosis
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse	Charles Wood
PPARgamma activation leading to sarcomas in rats, mice, and hamsters	Charles Wood
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation	Dalma Martinovic-Weigelt	Prolyl hydroxylase	reproductive dysfunction
Queen egg-laying decrease leads to colony loss/failure	Carlie LaLone
Sodium channel (Nav1.1) inhibition leading to population decline	Kellie Fay
Sodium channel inhibition leading to congenital malformations	Kellie Fay	sodium channel	congenital malformations
sodium channel inhibition leading to increased predation	Kellie Fay	sodium channel	increased predation
Sodium channel inhibition leading to reduced survival	Kellie Fay	sodium channel	reduced survival
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Mary Gilbert	NIS	neurodevelopmental outcomes
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis	Jonathan Haselman
Thyroperoxidase inhibition leading to altered amphibian metamorphosis	Jonathan Haselman
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman
unknown MIE leading to renal failure and mortality	Kellie Fay
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription	Dalma Martinovic-Weigelt	Unknown	reproductive dysfunction
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)	Charles Wood	unclear	urothelial papillomas and carcinomas
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure	Carlie LaLone
Varroa mite infestation increases virus levels leading to colony loss/failure	Carlie LaLone
Weather event contributes abnormal foraging leading to colony loss/failure	Carlie LaLone
Weather event contributes to colony loss/failure	Carlie LaLone
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity	Tammy Stoker	DBH	reduced fecundity