5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline |
Kellie Fay |
619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) |
623: Increase, predation and 360: Decrease, Population growth rate |
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase |
Kellie Fay |
619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) |
1164: Increased, Population |
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline |
Kellie Fay |
619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) |
1141: Decreased, Reproductive Success and 360: Decrease, Population growth rate |
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase |
Kellie Fay |
619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) |
1163: Increased, Reproductive Success and 1164: Increased, Population |
AhR activation leading to hepatic steatosis |
Michelle Angrish |
18: Activation, AhR |
455: Accumulation, Liver lipid |
AKT2 activation leading to hepatic steatosis |
Michelle Angrish |
486: systemic inflammation leading to hepatic steatosis |
459: Increased, Liver Steatosis |
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation |
Tammy Stoker |
849: Inhibition, Antgonism of NE receptor |
527: Decreased, Decreased fecundity |
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) |
Charles Wood |
714: Increased, Binding of chemicals to 2u (serum) |
713: Increase, Adenomas/carcinomas (renal tubular) |
Altered ion channel activity leading impaired heart function |
Kevin Dreher |
697: impaired, ion channels |
351: Increased Mortality |
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat |
Charles Wood |
|
1079: Increased, Adenomas/carcinomas (mammary) |
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse |
Charles Wood |
|
1053: Promotion, ovarian adenomas and 1054: Promotion, ovarian granular cell tumors |
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats |
Tammy Stoker |
964: Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol |
972: Decreased fertility, Reduced number of oocytes ovulated |
Axonal sodium channel modulation leading to acute mortality |
Kellie Fay |
598: modulation, sodium channel |
351: Increased Mortality |
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse |
Charles Wood |
1038: Activation, beta-2 adrenergic receptor |
1044: Promotion, mesovarian leiomyomas |
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
786: Increase, Cytotoxicity (hepatocytes) |
719: Increase, hepatocellular adenomas and carcinomas |
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. |
Charles Wood |
|
1090: Increased, mesotheliomas |
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality |
Kellie Fay |
1103: Inhibition, Cyclooxygenase 1 activity |
351: Increased Mortality and 360: Decrease, Population growth rate |
Cyclooxygenase inhibition leading reproductive failure |
Dan Villeneuve |
79: Inhibition, Cyclooxygenase activity |
253: N/A, Reproductive failure |
Cyclooxygenase inhibition leading to reproductive dysfunction |
Dalma Martinovic-Weigelt |
79: Inhibition, Cyclooxygenase activity |
675: Reduced, Reproductive Success and 360: Decrease, Population trajectory |
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior |
Dalma Martinovic-Weigelt |
79: Inhibition, Cyclooxygenase activity |
675: Reduced, Reproductive Success and 360: Decrease, Population trajectory |
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release |
Dalma Martinovic-Weigelt |
79: Inhibition, Cyclooxygenase activity |
675: Reduced, Reproductive Success and 360: Decrease, Population trajectory |
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition |
Dalma Martinovic-Weigelt |
79: Inhibition, Cyclooxygenase activity |
675: Reduced, Reproductive Success and 360: Decrease, Population trajectory |
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint |
Dalma Martinovic-Weigelt |
79: Inhibition, Cyclooxygenase activity |
675: Reduced, Reproductive Success and 360: Decrease, Population trajectory |
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) |
Charles Wood |
770: Increase, Cytotoxicity (club cells) |
736: Increase, Adenomas/carcinomas (bronchioloalveolar) |
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) |
Charles Wood |
783: Increase, Cytotoxicity (tubular epithelial cells) |
713: Increase, Adenomas/carcinomas (renal tubular) |
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) |
Charles Wood |
742: Decreased, Androgen receptor activity |
745: Increase, Leydig cell tumors |
DNA methyltransferase inhibition leading to population decline (1) |
You Song |
1619: Increase, DNA methyltransferase inhibition |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
DNA methyltransferase inhibition leading to population decline (2) |
You Song |
1619: Increase, DNA methyltransferase inhibition |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
DNA methyltransferase inhibition leading to population decline (4) |
You Song |
1619: Increase, DNA methyltransferase inhibition |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
DNA methyltransferase inhibition leading to transgenerational effects (1) |
You Song |
1619: Increase, DNA methyltransferase inhibition |
1781: Decrease, Fecundity (F3) and 360: Decrease, Population trajectory |
DNA methyltransferase inhibition leading to transgenerational effects (2) |
You Song |
1619: Increase, DNA methyltransferase inhibition |
1781: Decrease, Fecundity (F3) and 360: Decrease, Population trajectory |
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
1156: Inhibition, Dual oxidase |
1101: Altered, Amphibian metamorphosis |
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. |
Charles Wood |
1064: prepubertal increase, Estrogen receptor (ER) activity |
1070: Increased, adenosquamous carcinomas of endometrium |
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse |
Charles Wood |
|
1026: Increased Apoptosis, Adenomas/carcinomas (follicular cell) |
Epigenetic modification of PPARG leading to adipogenesis |
Michelle Angrish |
228: peroxisome proliferator activated receptor promoter demethylation and 1454: chronic high fat diet |
1447: obesity |
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) |
Charles Wood |
780: Increase, Cytotoxicity (epithelial cells) |
779: Increase, Papillomas/carcinomas (squamous cells) |
ER agonism leading to reduced survival due to renal failure |
Tom Hutchinson |
111: Agonism, Estrogen receptor |
|
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males |
Tom Hutchinson |
111: Agonism, Estrogen receptor |
417: skewed, sex ratio |
Estrogen Receptor Activation and Female Precocious Puberty |
Jeff Welch |
|
|
Estrogen receptor agonism leading to reproductive dysfunction |
Tom Hutchinson |
111: Agonism, Estrogen receptor |
360: Decrease, Population trajectory and 363: Altered, Reproductive behaviour and 339: Altered, Larval development and 364: Impaired development of, Reproductive organs |
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival |
Kellie Fay |
593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel |
592: Reduced, survival |
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility |
Susan Laws |
494: Glucocorticoid Receptor Agonist, Activation |
406: impaired, Fertility |
Glutamate-gated chloride channel activation leading to acute mortality |
Helen Poynton |
760: Activation, Glutamate-gated chloride channel |
351: Increased Mortality and 765: Decreased, population 1 |
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. |
Charles Wood |
|
1079: Increased, Adenomas/carcinomas (mammary) |
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. |
Charles Wood |
|
1082: Increased, adenomas (pituitary) |
Handbook development AOP |
Dan Villeneuve |
|
|
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis |
Jonathan Haselman |
1157: Activation, Hepatic nuclear receptor(s) |
1101: Altered, Amphibian metamorphosis |
Histamine (H2) receptor antagonism leading to reduced survival |
Kellie Fay |
638: Antagonism, Histamine Receptor (H2) |
636: Decreased, survival and 588: Increased, predation |
HMG-CoA reductase inhibition leading to decreased fertility |
Kellie Fay |
804: Inhibition, HMG-CoA reductase |
330: Decrease, Fertility |
HNF4alpha suppression leading to hepatic steatosis |
Michelle Angrish |
461: Suppression, HNF4alpha |
|
HPPD inhibition leading to corneal papillomas and carcinomas (in rat) |
Charles Wood |
766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme |
779: Increase, Papillomas/carcinomas (squamous cells) |
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) |
Charles Wood |
746: Increase, Dopaminergic activity |
773: Increase, Endometrial adenocarcinomas |
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) |
Charles Wood |
790: Inhibition, 5α-reductase activity |
745: Increase, Leydig cell tumors |
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) |
Charles Wood |
737: Decreased, Uptake of inorganic iodide |
741: Increase, Adenomas/carcinomas (follicular cell) |
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme |
719: Increase, hepatocellular adenomas and carcinomas |
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) |
Charles Wood |
279: Thyroperoxidase, Inhibition |
741: Increase, Adenomas/carcinomas (follicular cell) |
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
1152: Inhibition, Iodotyrosine deiodinase (IYD) |
1101: Altered, Amphibian metamorphosis |
Juvenile hormone receptor agonism leading to male offspring induction associated population decline |
Knut Erik Tollefsen |
1205: Activation, Juvenile hormone receptor |
1208: Increased, Male offspring and 361: Decline, Population and 1210: Alteration, Food-web structures |
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis |
Gary Klinefelter |
653: Decreased testosterone by the fetal Leydig cells, Increased corticosterone and 654: Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists |
505: Decreased sperm quantity / quality in the adult, Decreased fertility |
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome |
Gary Klinefelter |
661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome |
505: Decreased sperm quantity / quality in the adult, Decreased fertility |
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell |
Gary Klinefelter |
642: Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol and 643: Decreased Cholesterol, Decreased Uptake of Lipoproteins and 644: Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane |
646: Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis |
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis |
Gary Klinefelter |
658: Decreased testosterone by the fetal Leydig cells, Increased estradiol and 659: Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists |
505: Decreased sperm quantity / quality in the adult, Decreased fertility |
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation |
Gary Klinefelter |
650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid |
520: Decreased sperm quantity or quality in the adult, Decreased fertility |
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis |
Gary Klinefelter |
662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis |
543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis |
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell |
Gary Klinefelter |
640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell |
520: Decreased sperm quantity or quality in the adult, Decreased fertility |
NFE2L2/FXR activation leading to hepatic steatosis |
Michelle Angrish |
478: Activation, NRF2 and 479: Activation, NR1H4 |
459: Increased, Liver Steatosis |
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure |
Carlie LaLone |
559: Activation, Nicotinic acetylcholine receptor |
563: Death/Failure, Colony |
Nosema infection causes abnormal role change that leads to colony loss/failure |
Carlie LaLone |
|
563: Death/Failure, Colony |
Nosema infection increases energetic demands leading to colony loss/failure |
Carlie LaLone |
|
563: Death/Failure, Colony |
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis |
Michelle Angrish |
245: Activation, PXR/SXR |
459: Increased, Liver Steatosis |
NR1I3 (CAR) suppression leading to hepatic steatosis |
Michelle Angrish |
456: Suppression, Constitutive androstane receptor, NR1l3 and 468: Inhibition, PPAR alpha and 167: Activation, LXR and 228: peroxisome proliferator activated receptor promoter demethylation |
459: Increased, Liver Steatosis |
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality |
Kellie Fay |
877: Inhibition, organic anion transporter 1 (OAT1) |
351: Increased Mortality and 360: Decrease, Population growth rate |
Pendrin inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
1155: Inhibition, Pendrin |
1101: Altered, Amphibian metamorphosis |
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis |
Michelle Angrish |
231: Decreased, PPAR-alpha activation and 232: Decreased, PPAR-beta activation and 233: Decreased, PPAR-gamma activation |
459: Increased, Liver Steatosis |
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse |
Charles Wood |
|
1063: Increased, Pancreatic acinar tumors |
PPARgamma activation leading to sarcomas in rats, mice, and hamsters |
Charles Wood |
1028: Activation of specific nuclear receptors, PPAR-gamma activation |
|
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation |
Dalma Martinovic-Weigelt |
798: Inhibition, Prolyl hydroxylases |
78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory |
Queen egg-laying decrease leads to colony loss/failure |
Carlie LaLone |
|
563: Death/Failure, Colony |
Sodium channel (Nav1.1) inhibition leading to population decline |
Kellie Fay |
584: Inhibition, sodium channel |
|
Sodium channel inhibition leading to congenital malformations |
Kellie Fay |
584: Inhibition, sodium channel |
591: Increased, amputations |
sodium channel inhibition leading to increased predation |
Kellie Fay |
584: Inhibition, sodium channel |
588: Increased, predation |
Sodium channel inhibition leading to reduced survival |
Kellie Fay |
584: Inhibition, sodium channel |
587: Reduced, feeding 1 and 588: Increased, predation and 592: Reduced, survival |
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Mary Gilbert |
424: Inhibition, Na+/I- symporter (NIS) |
402: Cognitive Function, Decreased |
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
424: Inhibition, Na+/I- symporter (NIS) |
1101: Altered, Amphibian metamorphosis |
Thyroperoxidase inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
279: Thyroperoxidase, Inhibition |
1101: Altered, Amphibian metamorphosis |
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
1009: Inhibition, Deiodinase 1 |
1101: Altered, Amphibian metamorphosis |
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
1002: Inhibition, Deiodinase 2 |
1101: Altered, Amphibian metamorphosis |
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
1153: Inhibition, Deiodinase 3 |
1101: Altered, Amphibian metamorphosis |
unknown MIE leading to renal failure and mortality |
Kellie Fay |
1114: Unknown, MIE |
351: Increased Mortality |
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription |
Dalma Martinovic-Weigelt |
801: modulation, Unknown |
78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory |
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) |
Charles Wood |
793: Increase, Urinary bladder calculi |
797: Increase, Adenomas/carcinomas (urothelial) |
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure |
Carlie LaLone |
|
563: Death/Failure, Colony |
Varroa mite infestation increases virus levels leading to colony loss/failure |
Carlie LaLone |
|
563: Death/Failure, Colony |
Weather event contributes abnormal foraging leading to colony loss/failure |
Carlie LaLone |
|
563: Death/Failure, Colony |
Weather event contributes to colony loss/failure |
Carlie LaLone |
|
563: Death/Failure, Colony |
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity |
Tammy Stoker |
526: Inhibition, Inhibition of Dopamine-beta-hydroxylase |
527: Decreased, Decreased fecundity |