5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline |
Kellie Fay |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
- Increase, predation
- Decrease, Population growth rate
|
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase |
Kellie Fay |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
|
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline |
Kellie Fay |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
- Decreased, Reproductive Success
- Decrease, Population growth rate
|
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase |
Kellie Fay |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
- Increased, Reproductive Success
- Increased, Population
|
AhR activation leading to hepatic steatosis |
Michelle Angrish |
|
- Accumulation, Liver lipid
|
AKT2 activation leading to hepatic steatosis |
Michelle Angrish |
- systemic inflammation leading to hepatic steatosis
|
- Increased, Liver Steatosis
|
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation |
Tammy Stoker |
- Inhibition, Antgonism of NE receptor
|
- Decreased, Decreased fecundity
|
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) |
Charles Wood |
- Increased, Binding of chemicals to 2u (serum)
|
- Increase, Adenomas/carcinomas (renal tubular)
|
Altered ion channel activity leading impaired heart function |
Kevin Dreher |
|
|
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat |
Charles Wood |
|
- Increased, Adenomas/carcinomas (mammary)
|
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse |
Charles Wood |
|
- Promotion, ovarian adenomas
- Promotion, ovarian granular cell tumors
|
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats |
Tammy Stoker |
- Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
|
- Decreased fertility, Reduced number of oocytes ovulated
|
Axonal sodium channel modulation leading to acute mortality |
Kellie Fay |
- modulation, sodium channel
|
|
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse |
Charles Wood |
- Activation, beta-2 adrenergic receptor
|
- Promotion, mesovarian leiomyomas
|
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
- Increase, Cytotoxicity (hepatocytes)
|
- Increase, hepatocellular adenomas and carcinomas
|
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. |
Charles Wood |
|
|
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality |
Kellie Fay |
- Inhibition, Cyclooxygenase 1 activity
|
- Increased Mortality
- Decrease, Population growth rate
|
Cyclooxygenase inhibition leading reproductive failure |
Dan Villeneuve |
- Inhibition, Cyclooxygenase activity
|
- N/A, Reproductive failure
|
Cyclooxygenase inhibition leading to reproductive dysfunction |
Dalma Martinovic-Weigelt |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
|
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior |
Dalma Martinovic-Weigelt |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
|
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release |
Dalma Martinovic-Weigelt |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
|
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition |
Dalma Martinovic-Weigelt |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
|
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint |
Dalma Martinovic-Weigelt |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
|
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) |
Charles Wood |
- Increase, Cytotoxicity (club cells)
|
- Increase, Adenomas/carcinomas (bronchioloalveolar)
|
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) |
Charles Wood |
- Increase, Cytotoxicity (tubular epithelial cells)
|
- Increase, Adenomas/carcinomas (renal tubular)
|
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) |
Charles Wood |
- Decreased, Androgen receptor activity
|
- Increase, Leydig cell tumors
|
DNA methyltransferase inhibition leading to population decline (1) |
You Song |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity
- Decrease, Population growth rate
|
DNA methyltransferase inhibition leading to population decline (2) |
You Song |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity
- Decrease, Population growth rate
|
DNA methyltransferase inhibition leading to population decline (4) |
You Song |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity
- Decrease, Population growth rate
|
DNA methyltransferase inhibition leading to transgenerational effects (1) |
You Song |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity (F3)
- Decrease, Population growth rate
|
DNA methyltransferase inhibition leading to transgenerational effects (2) |
You Song |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity (F3)
- Decrease, Population growth rate
|
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
|
- Altered, Amphibian metamorphosis
|
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. |
Charles Wood |
- prepubertal increase, Estrogen receptor (ER) activity
|
- Increased, adenosquamous carcinomas of endometrium
|
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse |
Charles Wood |
|
- Increase, Adenomas/carcinomas (follicular cell)
|
Epigenetic modification of PPARG leading to adipogenesis |
Michelle Angrish |
- peroxisome proliferator activated receptor promoter demethylation
- chronic high fat diet
|
|
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) |
Charles Wood |
- Increase, Cytotoxicity (epithelial cells)
|
- Increase, Papillomas/carcinomas (squamous cells)
|
ER agonism leading to reduced survival due to renal failure |
Tom Hutchinson |
- Agonism, Estrogen receptor
|
|
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males |
Tom Hutchinson |
- Agonism, Estrogen receptor
|
|
Estrogen Receptor Activation and Female Precocious Puberty |
Jeff Welch |
|
|
Estrogen receptor agonism leading to reproductive dysfunction |
Tom Hutchinson |
- Agonism, Estrogen receptor
|
- Decrease, Population growth rate
- Altered, Reproductive behaviour
- Altered, Larval development
- Impaired development of, Reproductive organs
|
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival |
Kellie Fay |
- Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
|
|
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility |
Susan Laws |
- Glucocorticoid Receptor Agonist, Activation
|
|
Glutamate-gated chloride channel activation leading to acute mortality |
Helen Poynton |
- Activation, Glutamate-gated chloride channel
|
- Increased Mortality
- Decreased, population 1
|
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. |
Charles Wood |
|
- Increased, Adenomas/carcinomas (mammary)
|
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. |
Charles Wood |
|
- Increased, adenomas (pituitary)
|
Handbook development AOP |
Dan Villeneuve |
|
|
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis |
Jonathan Haselman |
- Activation, Hepatic nuclear receptor(s)
|
- Altered, Amphibian metamorphosis
|
Histamine (H2) receptor antagonism leading to reduced survival |
Kellie Fay |
- Antagonism, Histamine Receptor (H2)
|
- Decreased, survival
- Increased, predation
|
HMG-CoA reductase inhibition leading to decreased fertility |
Kellie Fay |
- Inhibition, HMG-CoA reductase
|
|
HNF4alpha suppression leading to hepatic steatosis |
Michelle Angrish |
|
|
HPPD inhibition leading to corneal papillomas and carcinomas (in rat) |
Charles Wood |
- Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
|
- Increase, Papillomas/carcinomas (squamous cells)
|
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) |
Charles Wood |
- Increase, Dopaminergic activity
|
- Increase, Endometrial adenocarcinomas
|
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) |
Charles Wood |
- Inhibition, 5α-reductase activity
|
- Increase, Leydig cell tumors
|
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) |
Charles Wood |
- Inhibition, Na+/I- symporter (NIS)
|
- Increase, Adenomas/carcinomas (follicular cell)
|
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
- Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
|
- Increase, hepatocellular adenomas and carcinomas
|
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) |
Charles Wood |
- Thyroperoxidase, Inhibition
|
- Increase, Adenomas/carcinomas (follicular cell)
|
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
- Inhibition, Iodotyrosine deiodinase (IYD)
|
- Altered, Amphibian metamorphosis
|
Juvenile hormone receptor agonism leading to male offspring induction associated population decline |
Knut Erik Tollefsen |
- Activation, Juvenile hormone receptor
|
- Increased, Male offspring
- Decline, Population
- Alteration, Food-web structures
|
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis |
Gary Klinefelter |
- Decreased testosterone by the fetal Leydig cells, Increased corticosterone
- Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
|
- Decreased sperm quantity / quality in the adult, Decreased fertility
|
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome |
Gary Klinefelter |
- Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
|
- Decreased sperm quantity / quality in the adult, Decreased fertility
|
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell |
Gary Klinefelter |
- Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol
- Decreased Cholesterol, Decreased Uptake of Lipoproteins
- Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
|
- Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
|
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis |
Gary Klinefelter |
- Decreased testosterone by the fetal Leydig cells, Increased estradiol
- Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists
|
- Decreased sperm quantity / quality in the adult, Decreased fertility
|
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation |
Gary Klinefelter |
- Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
|
- Decreased sperm quantity or quality in the adult, Decreased fertility
|
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis |
Gary Klinefelter |
- Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
|
- Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
|
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell |
Gary Klinefelter |
- Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
|
- Decreased sperm quantity or quality in the adult, Decreased fertility
|
NFE2L2/FXR activation leading to hepatic steatosis |
Michelle Angrish |
- Activation, NRF2
- Activation, NR1H4
|
- Increased, Liver Steatosis
|
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure |
Carlie LaLone |
- Activation, Nicotinic acetylcholine receptor
|
|
Nosema infection causes abnormal role change that leads to colony loss/failure |
Carlie LaLone |
|
|
Nosema infection increases energetic demands leading to colony loss/failure |
Carlie LaLone |
|
|
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis |
Michelle Angrish |
|
- Increased, Liver Steatosis
|
NR1I3 (CAR) suppression leading to hepatic steatosis |
Michelle Angrish |
- Suppression, Constitutive androstane receptor, NR1l3
- Inhibition, PPAR alpha
- Activation, LXR
- peroxisome proliferator activated receptor promoter demethylation
|
- Increased, Liver Steatosis
|
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality |
Kellie Fay |
- Inhibition, organic anion transporter 1 (OAT1)
|
- Increased Mortality
- Decrease, Population growth rate
|
Pendrin inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
|
- Altered, Amphibian metamorphosis
|
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis |
Michelle Angrish |
- Decreased, PPAR-alpha activation
- Decreased, PPAR-beta activation
- Decreased, PPAR-gamma activation
|
- Increased, Liver Steatosis
|
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse |
Charles Wood |
|
- Increased, Pancreatic acinar tumors
|
PPARgamma activation leading to sarcomas in rats, mice, and hamsters |
Charles Wood |
- Activation of specific nuclear receptors, PPAR-gamma activation
|
|
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation |
Dalma Martinovic-Weigelt |
- Inhibition, Prolyl hydroxylases
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
|
Queen egg-laying decrease leads to colony loss/failure |
Carlie LaLone |
|
|
Sodium channel (Nav1.1) inhibition leading to population decline |
Kellie Fay |
- Inhibition, sodium channel
|
|
Sodium channel inhibition leading to congenital malformations |
Kellie Fay |
- Inhibition, sodium channel
|
|
sodium channel inhibition leading to increased predation |
Kellie Fay |
- Inhibition, sodium channel
|
|
Sodium channel inhibition leading to reduced survival |
Kellie Fay |
- Inhibition, sodium channel
|
- Reduced, feeding 1
- Increased, predation
- Reduced, survival
|
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Mary Gilbert |
- Inhibition, Na+/I- symporter (NIS)
|
- Cognitive Function, Decreased
|
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
- Inhibition, Na+/I- symporter (NIS)
|
- Altered, Amphibian metamorphosis
|
Thyroperoxidase inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
- Thyroperoxidase, Inhibition
|
- Altered, Amphibian metamorphosis
|
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
|
- Altered, Amphibian metamorphosis
|
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
|
- Altered, Amphibian metamorphosis
|
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
|
- Altered, Amphibian metamorphosis
|
unknown MIE leading to renal failure and mortality |
Kellie Fay |
|
|
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription |
Dalma Martinovic-Weigelt |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
|
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) |
Charles Wood |
- Increase, Urinary bladder calculi
|
- Increase, Adenomas/carcinomas (urothelial)
|
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure |
Carlie LaLone |
|
|
Varroa mite infestation increases virus levels leading to colony loss/failure |
Carlie LaLone |
|
|
Weather event contributes abnormal foraging leading to colony loss/failure |
Carlie LaLone |
|
|
Weather event contributes to colony loss/failure |
Carlie LaLone |
|
|
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity |
Tammy Stoker |
- Inhibition, Inhibition of Dopamine-beta-hydroxylase
|
- Decreased, Decreased fecundity
|