Prototypical Stressors

Showing 326 to 350 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

328	Gentamicin	Gentamicin, CAS-RN: 1403-66-3, DTXSID5034642	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
329	Tobramycin	Tobramycin, CAS-RN: 32986-56-4, DTXSID8023680	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
330	Vancomycin	Vancomycin, CAS-RN: 1404-90-6, DTXSID0042664	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
331	Polymyxin B	Polymyxin B, CAS-RN: 1404-26-8, DTXSID1048467	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
332	Colistin	Colistin, CAS-RN: 1066-17-7, DTXSID1040663	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
333	Albumin	Albumin, CAS-RN: 308060-74-4, DTXSID1040409	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
334	low molecular weight proteins		257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
335	Cadmium	Cadmium, CAS-RN: 7440-43-9, DTXSID1023940	10 AOPs 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 521: Essential element imbalance leads to reproductive failure via oxidative stress 550: Increased LMNA gene mutation leading to heart failure 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure 560: Inhibition of Funny current (If) leading to Arrhythmias 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
336	Acrylamide	Acrylamide, CAS-RN: 79-06-1, DTXSID5020027	17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
337	Bleomycin	Bleomycin, CAS-RN: 11056-06-7, DTXSID1030862	2 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 550: Increased LMNA gene mutation leading to heart failure
338	Carbon nanotubes, Multi-walled carbon nanotubes, single-walled carbon nanotubes, carbon nanofibres		2 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 409: Frustrated phagocytosis leads to malignant mesothelioma
339	Carbon nanotubes, Multi-walled carbon nanotubes, Single-walled carbon nanotubes, carbon fibres		None
340	Methoxyacetic acid	Methoxyacetic acid, CAS-RN: 625-45-6, DTXSID1031591	212: Histone deacetylase inhibition leading to testicular atrophy
341	Butyrate	Butyrate, CAS-RN: 461-55-2, DTXSID8040432	2 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 274: Histone deacetylase inhibition leads to impeded craniofacial development
342	Trichostatin A	Trichostatin A, CAS-RN: 58880-19-6, DTXSID6037063	2 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 274: Histone deacetylase inhibition leads to impeded craniofacial development
343	thiomersal		None
344	Heptachlor	Heptachlor, CAS-RN: 76-44-8, DTXSID3020679	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
345	Endosulfan	Endosulfan, CAS-RN: 115-29-7, DTXSID1020560	2 AOPs 10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
346	Stressor:147 Dibenzo-p-dioxin		None
347	Polycyclic aromatic hydrocarbons	Polycyclic aromatic hydrocarbons, CAS-RN: 130498-29-2, DTXSID3044043	None
348	2,4-Dithiobiuret	2,4-Dithiobiuret, CAS-RN: 541-53-7, DTXSID2034968	None
349	dioxin		None
350	Enflurane	Enflurane, CAS-RN: 13838-16-9, DTXSID1020562	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
351	Halothane	Halothane, CAS-RN: 151-67-7, DTXSID4025371	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
352	Isoflurane	Isoflurane, CAS-RN: 26675-46-7, DTXSID3020752	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration