Prototypical Stressors

Showing 701 to 725 of 874 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

846	Picoxystrobin	Picoxystrobin, CAS-RN: 117428-22-5, DTXSID9047542	587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits
847	Muristerone A		342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
848	Cucurbitacin B		606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
849	Cucurbitacin D		606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
850	Deguelin	Deguelin, CAS-RN: 522-17-8, DTXSID10200231	3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
851	Pyrimidifen	Pyrimidifen, CAS-RN: 105779-78-0, DTXSID9057925	3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
852	Tebufenpyrad	Tebufenpyrad, CAS-RN: 119168-77-3, DTXSID0034223	3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
853	Brusatol		615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
854	ML385		615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
855	Metribuzin	Metribuzin, CAS-RN: 21087-64-9, DTXSID6024204	567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
856	Chlorotoluron	Chlorotoluron, CAS-RN: 15545-48-9, DTXSID8052853	567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
857	Oxaliplatin	Oxaliplatin, CAS-RN: 61825-94-3, DTXSID0036760	472: DNA adduct formation leading to kidney failure
858	Carboplatin	Carboplatin, CAS-RN: 41575-94-4, DTXSID3046742	472: DNA adduct formation leading to kidney failure
865	5-Methylchrysene	5-Methylchrysene, CAS-RN: 3697-24-3, DTXSID6063143	644: Bulky DNA adducts leading to chromosomal aberrations and mutations
866	3-Methylcholanthrene	3-Methylcholanthrene, CAS-RN: 56-49-5, DTXSID0020862	644: Bulky DNA adducts leading to chromosomal aberrations and mutations
867	2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine	2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine, CAS-RN: 105650-23-5, DTXSID3037628	644: Bulky DNA adducts leading to chromosomal aberrations and mutations
875	17-Methyltestosterone	17-Methyltestosterone, CAS-RN: 58-18-4, DTXSID1033664	547: Androgen receptor agonism leading to long anogenital distance (AGD) in female offspring
876	Testosterone propionate	Testosterone propionate, CAS-RN: 57-85-2, DTXSID9036515	547: Androgen receptor agonism leading to long anogenital distance (AGD) in female offspring
877	Lomitapide	Lomitapide, CAS-RN: 182431-12-5, DTXSID50171294	653: Inhibition to Microsomal Triglyceride Transfer Protein Leads to Steatosis
10	Benzo(k)fluoranthene	Benzo(k)fluoranthene, CAS-RN: 207-08-9, DTXSID0023909	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
11	Bis(2-ethylhexyl) phthalate	Di(2-ethylhexyl) phthalate, CAS-RN: 117-81-7, DTXSID5020607	2 AOPs 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
15	Diclofenac sodium	Diclofenac sodium, CAS-RN: 15307-79-6, DTXSID3037208	2 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
32	Letrozole	Letrozole, CAS-RN: 112809-51-5, DTXSID4023202 Fadrozole, CAS-RN: 102676-47-1, DTXSID5034141	2 AOPs 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
34	Mercaptobenzothiazole	2-Mercaptobenzothiazole, CAS-RN: 149-30-4, DTXSID1020807	2 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
35	Mercuric chloride	Mercuric chloride, CAS-RN: 7487-94-7, DTXSID5020811	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress