Prototypical Stressors

Showing 701 to 725 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

704	Disopyramide	Disopyramide, CAS-RN: 3737-09-5, DTXSID1045536	None
705	Procainamide	Procainamide, CAS-RN: 51-06-9, DTXSID7023512	None
706	Terfenadine	Terfenadine, CAS-RN: 50679-08-8, DTXSID2023642	2 AOPs 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
707	Cisapride	Cisapride, CAS-RN: 81098-60-4, DTXSID3022825	2 AOPs 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
708	Tetraarsenic trioxide	Tetraarsenic trioxide, CAS-RN: 83527-54-2, DTXSID80232428	None
709	Pentamidine	Pentamidine, CAS-RN: 100-33-4, DTXSID7023431	None
710	Geldanamycin	Geldanamycin, CAS-RN: 30562-34-6, DTXSID7042691	None
711	Silver	Silver, CAS-RN: 7440-22-4, DTXSID4024305	4 AOPs 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
712	Gold nanoparticles		None
713	Chromium	Chromium, CAS-RN: 7440-47-3, DTXSID3031022	None
714	Other heavy metal effects		None
715	Other heavy metals		None
716	Cisplatin	Cisplatin, CAS-RN: 15663-27-1, DTXSID4024983	472: DNA adduct formation leading to kidney failure
717	Nanoparticles and Micrometer Particles		None
718	Platinum		None
719	2) Aluminum		None
720	Aluminum	Aluminum, CAS-RN: 7429-90-5, DTXSID3040273	None
721	Manganese	Manganese, CAS-RN: 7439-96-5, DTXSID2024169	2 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
722	Nickel	Nickel, CAS-RN: 7440-02-0, DTXSID2020925	None
723	Zinc	Zinc, CAS-RN: 7440-66-6, DTXSID7035012	615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
724	Gold	Gold, CAS-RN: 7440-57-5, DTXSID3064697	None
725	All-trans retinoic acid		615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
726	BMS-89453		436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
727	WIN18446		None
728	4-diethylaminobenzaldehyde (DEAB)		436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries