Prototypical Stressors

Showing 726 to 750 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

729	WIN18466		436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
730	a		None
731	All-trans retionic acid		436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
732	Vitamin A		436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
733	Nanoparticles and micrometer		None
734	Clomiphene citrate (1:1)	Clomiphene citrate (1:1), CAS-RN: 50-41-9, DTXSID8020337	440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
735	Clomiphene	Clomiphene, CAS-RN: 911-45-5, DTXSID1022843	None
736	Tamoxifen epoxide	Tamoxifen epoxide, CAS-RN: 92137-93-4, DTXSID40238885	None
737	Ethyl alcohol		443: DNA damage and mutations leading to Metastatic Breast Cancer
738	Uranium, soluble salts	Uranium, soluble salts, CAS-RN: NOCAS, DTXSID7024374	447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
739	welding fumes		451: Interaction with lung resident cell membrane components leads to lung cancer
740	Carbon black	Carbon black, CAS-RN: 1333-86-4, DTXSID7051216	451: Interaction with lung resident cell membrane components leads to lung cancer
741	DCA		335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
742	DCPMU		335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
743	Niclosamide ethanolamine		263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
744	Oxyclozanide	Oxyclozanide, CAS-RN: 2277-92-1, DTXSID50177312	263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
745	Fumonisin B1	Fumonisin B1, CAS-RN: 116355-83-0, DTXSID6020644	449: Ceramide synthase inhibition leading to neural tube defects
746	Vismodegib	Vismodegib, CAS-RN: 879085-55-9, DTXSID40236689	460: Antagonism of Smoothened receptor leading to orofacial clefting
747	Toluene diisocyanate	Toluene diisocyanate, CAS-RN: 26471-62-5, DTXSID0024341	39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
748	Cyclopamine	Cyclopamine, CAS-RN: 4449-51-8, DTXSID6043709	None
749	Titanium dioxide nanoparticles		2 AOPs 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 451: Interaction with lung resident cell membrane components leads to lung cancer
750	Iron nanoparticles		392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
751	SANT1		None
752	SANT-1	(E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine, CAS-RN: 304909-07-7, DTXSID90425965	460: Antagonism of Smoothened receptor leading to orofacial clefting
753	SANT-2	SANT-2, CAS-RN: 329196-48-7, DTXSID40362255	460: Antagonism of Smoothened receptor leading to orofacial clefting