Prototypical Stressors

Showing 751 to 775 of 874 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

261	Tetrabromobisphenol A	3,3',5,5'-Tetrabromobisphenol A, CAS-RN: 79-94-7, DTXSID1026081	2 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
284	Aristolochic acid	Aristolochic acid, CAS-RN: 313-67-7, DTXSID0040969	2 AOPs 397: Bulky DNA adducts leading to mutations 644: Bulky DNA adducts leading to chromosomal aberrations and mutations
294	Cyclosporin		2 AOPs 154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
300	PPARalpha antagonists		2 AOPs 6: Antagonist binding to PPARα leading to body-weight loss 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
304	Tributyltin	Tributyltin, CAS-RN: 688-73-3, DTXSID0040709	2 AOPs 72: Epigenetic modification of PPARG leading to adipogenesis 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
310	Disulfiram	Tetraethylthiuram disulfide, CAS-RN: 97-77-8, DTXSID1021322	2 AOPs 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
319	Acrolein	Acrolein, CAS-RN: 107-02-8, DTXSID5020023	2 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
321	3,5-Dichlorophenol	3,5-Dichlorophenol, CAS-RN: 591-35-5, DTXSID2025006	2 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
337	Bleomycin	Bleomycin, CAS-RN: 11056-06-7, DTXSID1030862	2 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 550: Increased LMNA gene mutation leading to heart failure
338	Carbon nanotubes, Multi-walled carbon nanotubes, single-walled carbon nanotubes, carbon nanofibres		2 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 409: Frustrated phagocytosis leads to malignant mesothelioma
341	Butyrate	Butyrate, CAS-RN: 461-55-2, DTXSID8040432	2 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 274: Histone deacetylase inhibition leads to impeded craniofacial development
342	Trichostatin A	Trichostatin A, CAS-RN: 58880-19-6, DTXSID6037063	2 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 274: Histone deacetylase inhibition leads to impeded craniofacial development
345	Endosulfan	Endosulfan, CAS-RN: 115-29-7, DTXSID1020560	2 AOPs 10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
360	Ethanol	Ethanol, CAS-RN: 64-17-5, DTXSID9020584	2 AOPs 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
367	Diuron	Diuron, CAS-RN: 330-54-1, DTXSID0020446	2 AOPs 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
378	Virus		2 AOPs 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
382	Nifedipine	Nifedipine, CAS-RN: 21829-25-4, DTXSID2025715	2 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
383	Amlodipine	Amlodipine, CAS-RN: 88150-42-9, DTXSID7022596	2 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
386	Nimodipine	Nimodipine, CAS-RN: 66085-59-4, DTXSID5023370	2 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
388	Diltiazem	(+)-Diltiazem, CAS-RN: 42399-41-7, DTXSID9022940	2 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
391	Ciprofloxacin	Ciprofloxacin, CAS-RN: 85721-33-1, DTXSID8022824	2 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
443	Decitabine	Decitabine, CAS-RN: 2353-33-5, DTXSID7030432	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
444	Sinefungin	Sinefungin, CAS-RN: 58944-73-3, DTXSID10207689	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
445	Psammaplin A		2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
446	Hydralazine hydrochloride	Hydralazine hydrochloride, CAS-RN: 304-20-1, DTXSID1044645	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)