Prototypical Stressors

Showing 751 to 775 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

754	SANT-3		460: Antagonism of Smoothened receptor leading to orofacial clefting
755	SANT-4		460: Antagonism of Smoothened receptor leading to orofacial clefting
756	GANT61	GANT61, CAS-RN: 500579-04-4, DTXSID50329591	491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
757	GANT 58		491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
758	3,3′,5,5′ tetrabromobisphenol A		2 AOPs 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition
759	NH-375		485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
760	Lei Gong Teng (Common Threewingnut Root)		486: Binding to the extracellular protein laminin leading to decreased cognitive function
761	Tian Ma (Tall Gastrodia Tuber)		2 AOPs 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function
762	Deltamethrin		489: Inhibition of voltage-gated sodium channels leading to decreased cognition
763	Altered Gravity		None
764	Preferred: Altered Gravity		None
765	Piperonyl butoxide	Piperonyl butoxide, CAS-RN: 51-03-6, DTXSID1021166	None
766	Chlorpyrifos oxon	Chlorpyrifos oxon, CAS-RN: 5598-15-2, DTXSID1038666	490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
767	Diethyl maleate	Diethyl maleate, CAS-RN: 141-05-9, DTXSID8020464	492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
768	PCB 126		2 AOPs 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
769	Polyethylene AS low Mol.Wt.	Polyethylene AS low Mol.Wt., CAS-RN: 9002-88-4, DTXSID8031946	505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
770	Polyvinyl chloride	Polyvinyl chloride, CAS-RN: 9002-86-2, DTXSID5025940	505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
771	Perfluorooctanesulfonic acid	Perfluorooctanesulfonic acid, CAS-RN: 1763-23-1, DTXSID3031864	529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
772	PPAR agonist		529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
773	Per- and Polyfluorinated Substances (PFAS)		529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
774	Boscalid	Boscalid, CAS-RN: 188425-85-6, DTXSID6034392	3 AOPs 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
775	Bixafen	Bixafen, CAS-RN: 581809-46-3, DTXSID6058134	3 AOPs 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
776	Sedaxane	Sedaxane, CAS-RN: 874967-67-6, DTXSID2058207	3 AOPs 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
777	Sodium L-glutamate	Sodium L-glutamate, CAS-RN: 142-47-2, DTXSID9020906	475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
778	amyloid beta		475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons