Prototypical Stressors

Showing 776 to 800 of 874 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

447	Zebularine		2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
448	RG 108		2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
449	Temozolomide	Temozolomide, CAS-RN: 85622-93-1, DTXSID5043714	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
453	Other DNA damaging agents		2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
465	nitrofen	Nitrofen, CAS-RN: 1836-75-5, DTXSID7020970	2 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
467	Bisdiamine		2 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
492	Dexamethasone	Dexamethasone, CAS-RN: 50-02-2, DTXSID3020384	2 AOPs 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
500	High aspect ratio material		2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
509	benzo[a]pyrene		2 AOPs 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
546	Malathion	Malathion, CAS-RN: 121-75-5, DTXSID4020791	2 AOPs 551: Increased Muscarinic M2 Receptor leading to Arrhythmia 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
548	Triphenyl phosphate	Triphenyl phosphate, CAS-RN: 115-86-6, DTXSID1021952	2 AOPs 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
603	Triclosan	Triclosan, CAS-RN: 3380-34-5, DTXSID5032498	2 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
620	HCoV-NL63		2 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
634	nanomaterials		2 AOPs 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 451: Interaction with lung resident cell membrane components leads to lung cancer
638	(-)-Epigallocatechin gallate	(-)-Epigallocatechin gallate, CAS-RN: 989-51-5, DTXSID1029889	2 AOPs 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response 486: Binding to the extracellular protein laminin leading to decreased cognitive function
649	Paraoxon	Paraoxon, CAS-RN: 311-45-5, DTXSID6024046	2 AOPs 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
651	Ethyl Parathion		2 AOPs 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
655	Ozone	Ozone, CAS-RN: 10028-15-6, DTXSID0021098	2 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
664	Uranium	Uranium, CAS-RN: 7440-61-1, DTXSID1042522	2 AOPs 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
667	Diesel engine exhaust	Diesel engine exhaust, CAS-RN: NOCAS, DTXSID1024043	2 AOPs 411: Oxidative stress Leading to Decreased Lung Function 451: Interaction with lung resident cell membrane components leads to lung cancer
706	Terfenadine	Terfenadine, CAS-RN: 50679-08-8, DTXSID2023642	2 AOPs 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
707	Cisapride	Cisapride, CAS-RN: 81098-60-4, DTXSID3022825	2 AOPs 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
721	Manganese	Manganese, CAS-RN: 7439-96-5, DTXSID2024169	2 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
749	Titanium dioxide nanoparticles		2 AOPs 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 451: Interaction with lung resident cell membrane components leads to lung cancer
758	3,3′,5,5′ tetrabromobisphenol A		2 AOPs 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition