Prototypical Stressors

Showing 226 to 250 of 871 Prototypical Stressors

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ID Prototypical Stressor Name Associated Chemical(s): Name, CAS-RN, DTXSID Associated AOPs
380 Calcium channel blockers
261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
731 All-trans retionic acid
436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
579 PF915275
348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
578 Glycyrrhizin
  • Glycyrrhizin, CAS-RN: 1405-86-3, DTXSID8047006
348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
577 Osilodrostat(LCI699)
349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
466 4-biphenyl carboxylic acid
297: Inhibition of retinaldehyde dehydrogenase leads to population decline
486 minocycline
  • Minocycline, CAS-RN: 10118-90-8, DTXSID1045033
277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
531 Kaempferol
  • Kaempferol, CAS-RN: 520-18-3, DTXSID7020768
154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
681 Prototypical stressor
211: Handbook development AOP
474 BIO (6-bromoindirubin-3’-oxime)
410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
471 WNT2
298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
470 Wnt
298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
469 Vinblastine sulfate
  • Vinrosidine sulfate (1:x), CAS-RN: 18556-44-0, DTXSID7047853
106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
468 SB-210661
297: Inhibition of retinaldehyde dehydrogenase leads to population decline
532 Dodecylbenzene sulfonate
154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
533 Dibefurin
154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
534 Ascomycin
154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
461 Disulphiram
297: Inhibition of retinaldehyde dehydrogenase leads to population decline
455 Potassium bromate
  • Potassium bromate, CAS-RN: 7758-01-2, DTXSID6020195
296: Oxidative DNA damage leading to chromosomal aberrations and mutations
648 work stress
403: combined unhealthy lifestyle factors leading to metabolic syndrome
456 Cadmium chloride
  • Cadmium chloride, CAS-RN: 10108-64-2, DTXSID6020226
296: Oxidative DNA damage leading to chromosomal aberrations and mutations
545 Carbenoxolone
  • Carbenoxolone, CAS-RN: 5697-56-3, DTXSID4022733
348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
541 psychosocial stress
403: combined unhealthy lifestyle factors leading to metabolic syndrome
463 Citral
297: Inhibition of retinaldehyde dehydrogenase leads to population decline
535 1,5-dibenzoyloxymethyl-norcantharidin
154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response