Prototypical Stressors

Showing 226 to 250 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

649	Paraoxon	Paraoxon, CAS-RN: 311-45-5, DTXSID6024046	2 AOPs 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
648	work stress		403: combined unhealthy lifestyle factors leading to metabolic syndrome
647	physical inactivity		403: combined unhealthy lifestyle factors leading to metabolic syndrome
646	high fat diet		403: combined unhealthy lifestyle factors leading to metabolic syndrome
645	Cigarette smoke	Cigarette smoke, CAS-RN: NOCAS, DTXSID5035038	5 AOPs 403: combined unhealthy lifestyle factors leading to metabolic syndrome 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
644	Rocilinostat / Ricolinostat		None
643	Staurosporine	Staurosporine, CAS-RN: 62996-74-1, DTXSID6041131	399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
642	Saracatinib	Saracatinib, CAS-RN: 379231-04-6, DTXSID90191355	399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
641	Rosmarinic acid		399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
640	11-Keto-testosterone	11-Ketotestosterone, CAS-RN: 564-35-2, DTXSID8036499	376: Androgen receptor agonism leading to male-biased sex ratio
639	Methyldihydrotestosterone		376: Androgen receptor agonism leading to male-biased sex ratio
638	(-)-Epigallocatechin gallate	(-)-Epigallocatechin gallate, CAS-RN: 989-51-5, DTXSID1029889	2 AOPs 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response 486: Binding to the extracellular protein laminin leading to decreased cognitive function
637	Dimethyl fumarate		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
636	Dehydroxymethylepoxyquinomicin (DHMEQ)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
635	Arsenic	Arsenic, CAS-RN: 7440-38-2, DTXSID4023886	5 AOPs 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 550: Increased LMNA gene mutation leading to heart failure 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
634	nanomaterials		2 AOPs 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 451: Interaction with lung resident cell membrane components leads to lung cancer
633	Stressor:624 SARS-CoV-2		379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
632	Pathogen Associated Molecular Patterns (PAMPs)		377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
631	Danger Associated Molecular Patters (DAMPs)		377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
630	Chemical:33664 17-Methyltestosterone		376: Androgen receptor agonism leading to male-biased sex ratio
629	unmethylated CpG motifs (DNA;RNA;ODN)		377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
628	cell free mitochondrial DNA (mtDNA)		377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
627	Dummy Stressor		None
626	fungi		None
625	bacteria		374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis