| 785 |
Camptothecin
|
|
550: Increased LMNA gene mutation leading to heart failure
|
| 728 |
4-diethylaminobenzaldehyde (DEAB)
|
|
436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
|
| 786 |
Carbamate pesticides
|
|
551: Increased Muscarinic M2 Receptor leading to Arrhythmia
|
| 726 |
BMS-89453
|
|
436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
|
| 787 |
Cholinergic drugs
|
|
551: Increased Muscarinic M2 Receptor leading to Arrhythmia
|
| 788 |
Halogenated Hydrocarbons
|
|
519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
|
| 725 |
All-trans retinoic acid
|
|
615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
|
| 723 |
Zinc
|
-
Zinc, CAS-RN: 7440-66-6, DTXSID7035012
|
615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
|
| 789 |
terfenadine
|
|
519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
|
| 716 |
Cisplatin
|
-
Cisplatin, CAS-RN: 15663-27-1, DTXSID4024983
|
472: DNA adduct formation leading to kidney failure
|
| 790 |
Flecainide
|
|
553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
|
| 791 |
Bupivacaine
|
|
553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
|
| 792 |
Tetracaine
|
|
553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
|
| 699 |
Influenza Virus
|
|
506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
|
| 698 |
Diethylhexyl phthalate
|
|
431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
|
| 681 |
Prototypical stressor
|
|
211: Handbook development AOP
|
| 793 |
Saxitoxin
|
|
553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
|
| 673 |
Nitrogen dioxide
|
-
Nitrogen dioxide, CAS-RN: 10102-44-0, DTXSID7020974
|
411: Oxidative stress Leading to Decreased Lung Function
|
| 794 |
Tetrodotoxin derivatives
|
|
553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
|
| 671 |
Asbestos fibers
|
-
Asbestos fibers, CAS-RN: NOCAS, DTXSID0030740
|
409: Frustrated phagocytosis leads to malignant mesothelioma
|
| 440 |
Photoreactive chemicals
|
|
282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
|
| 665 |
Bis(2,4,6-trimethylphenyl)-lambda~2~-germane--selenium (1/1)
|
-
Bis(2,4,6-trimethylphenyl)-lambda~2~-germane--selenium (1/1), CAS-RN: 115385-04-1, DTXSID10556604
|
413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
|
| 810 |
Forskolin
|
|
558: Phosphodiesterase inhibition leading to heart failure
|
| 813 |
Donepezil
|
|
559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
|
| 814 |
Neostigmine
|
|
559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
|