Prototypical Stressors

Showing 676 to 700 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

197	coumatetralyl	Coumatetralyl, CAS-RN: 5836-29-3, DTXSID8041799	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
196	coumachlor	Coumachlor, CAS-RN: 81-82-3, DTXSID8041797	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
195	Warfarin	Warfarin, CAS-RN: 81-81-2, DTXSID5023742	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
194	Carprofen	Carprofen, CAS-RN: 53716-49-7, DTXSID1045871	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
193	nimesulide	Nimesulide, CAS-RN: 51803-78-2, DTXSID3037250	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
192	Meloxicam	Meloxicam, CAS-RN: 71125-38-7, DTXSID1020803	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
191	Clofibrate	Clofibrate, CAS-RN: 637-07-0, DTXSID3020336	3 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
190	flunixin meglumine	Flunixin meglumine, CAS-RN: 42461-84-7, DTXSID1045584	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
189	Mefenamic acid	Mefenamic acid, CAS-RN: 61-68-7, DTXSID5023243	None
188	Diflunisal	Diflunisal, CAS-RN: 22494-42-4, DTXSID5022932	None
187	Telmisartan	Telmisartan, CAS-RN: 144701-48-4, DTXSID8023636	None
186	Ketorolac Tromethamine	Ketorolac tromethamine, CAS-RN: 74103-07-4, DTXSID0045597	None
185	Nitazoxanide	Nitazoxanide, CAS-RN: 55981-09-4, DTXSID5033757	None
184	Oxaprozin	Oxaprozin, CAS-RN: 21256-18-8, DTXSID1045118	None
183	Amlexanox		None
182	Phenylbutazone	4-Butyl-1,2-diphenyl-3,5-Pyrazolidinedione, CAS-RN: 50-33-9, DTXSID9021136	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
181	Ketoprofen	Ketoprofen, CAS-RN: 22071-15-4, DTXSID6020771	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
180	2,4-Dinitrophenol	2,4-Dinitrophenol, CAS-RN: 51-28-5, DTXSID0020523	263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
179	Reserpine	Reserpine, CAS-RN: 50-55-5, DTXSID7021237	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
178	Haloperidol	Haloperidol, CAS-RN: 52-86-8, DTXSID4034150	2 AOPs 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
177	atrazine	Atrazine, CAS-RN: 1912-24-9, DTXSID9020112	5 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
176	Diethylstilbestrol	Diethylstilbestrol, CAS-RN: 56-53-1, DTXSID3020465	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
175	PERFLUOROOCTANOIC ACID		2 AOPs 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
174	Fulvestrant	Fulvestrant, CAS-RN: 129453-61-8, DTXSID4022369	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
173	Raloxifene	Raloxifene, CAS-RN: 84449-90-1, DTXSID3023550	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia