Prototypical Stressors

Showing 701 to 725 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

172	Tamoxifen	Tamoxifen, CAS-RN: 10540-29-1, DTXSID1034187	3 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
171	Pyrethrins and Pyrethroids		3 AOPs 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
170	thiazopyr	Thiazopyr, CAS-RN: 117718-60-2, DTXSID1032488	162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
169	Sunitinib malate Sunitinib (INN)		43: Disruption of VEGFR Signaling Leading to Developmental Defects
168	2-Imidazolidinimine, 1-[(6-chloro-3-pyridinyl)methyl]-N-nitro-, (2E)-		None
167	1',2'-dihydrorotenone	1',2'-Dihydrorotenone, CAS-RN: 6659-45-6, DTXSID5041227	None
166	Benzoic acid, 4-chloro-, 2-benzoyl-2-(1,1-dimethylethyl)hydrazide		None
165	Benzoic acid, 3-methoxy-2-methyl-, 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide		None
164	Tebufenozide	Tebufenozide, CAS-RN: 112410-23-8, DTXSID4034948	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
163	Tacrolimus (also FK506)	Tacrolimus, CAS-RN: 104987-11-3, DTXSID5046354	2 AOPs 154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
162	1,2,4-triazole		153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
161	Levothyroxine	Levothyroxine, CAS-RN: 51-48-9, DTXSID8023214	None
160	Halogenated phenols		152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
159	dibenzofuran	Dibenzofuran, CAS-RN: 132-64-9, DTXSID2021993	None
158	Indole	Indole, CAS-RN: 120-72-9, DTXSID0020737	None
157	Gabapentin	Gabapentin, CAS-RN: 60142-96-3, DTXSID0020074	None
156	Aspartame	Aspartame, CAS-RN: 22839-47-0, DTXSID0020107	None
155	Propyl Acetate	Propyl acetate, CAS-RN: 109-60-4, DTXSID6021901	None
154	Ethyl acetate	Ethyl acetate, CAS-RN: 141-78-6, DTXSID1022001	None
153	Vinyl acetate	Vinyl acetate, CAS-RN: 108-05-4, DTXSID3021431	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
152	Penicillin		None
151	GW6471		6: Antagonist binding to PPARα leading to body-weight loss
150	Hexachlorobenzene	Hexachlorobenzene, CAS-RN: 118-74-1, DTXSID2020682	131: Aryl hydrocarbon receptor activation leading to uroporphyria
149	Polychlorinated dibenzofurans		150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
148	Polychlorinated biphenyl		5 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 131: Aryl hydrocarbon receptor activation leading to uroporphyria 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals