Prototypical Stressors

Showing 51 to 75 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

861	Anthracene	Anthracene, CAS-RN: 120-12-7, DTXSID0023878	3 AOPs 644: Bulky DNA adducts leading to chromosomal aberrations and mutations 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
862	Pyrene	Pyrene, CAS-RN: 129-00-0, DTXSID3024289	3 AOPs 644: Bulky DNA adducts leading to chromosomal aberrations and mutations 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
5	17beta-Trenbolone	17beta-Trenbolone, CAS-RN: 10161-33-8, DTXSID0034192	3 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 376: Androgen receptor agonism leading to male-biased sex ratio 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
26	Fadrozole	Fadrozole, CAS-RN: 102676-47-1, DTXSID5034141	3 AOPs 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 25: Aromatase inhibition leading to reproductive dysfunction
863	Benz(a)anthracene	Benz(a)anthracene, CAS-RN: 56-55-3, DTXSID5023902	3 AOPs 644: Bulky DNA adducts leading to chromosomal aberrations and mutations 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
318	Carbon nanotubes		3 AOPs 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response 409: Frustrated phagocytosis leads to malignant mesothelioma
864	Chrysene	Chrysene, CAS-RN: 218-01-9, DTXSID0022432	3 AOPs 644: Bulky DNA adducts leading to chromosomal aberrations and mutations 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
526	SARS-CoV		3 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
145	Finasteride		3 AOPs 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring
295	serotonin transporter activation		3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
795	Isoproterenol		2 AOPs 554: β-adrenergic receptor agonists leading to arrhythmias. 558: Phosphodiesterase inhibition leading to heart failure
128	Benomyl	Benomyl, CAS-RN: 17804-35-2, DTXSID5023900	2 AOPs 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
874	Benzo(g,h,i)perylene	Benzo(g,h,i)perylene, CAS-RN: 191-24-2, DTXSID5023908	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
445	Psammaplin A		2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
664	Uranium	Uranium, CAS-RN: 7440-61-1, DTXSID1042522	2 AOPs 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
509	benzo[a]pyrene		2 AOPs 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
133	Phenobarbital	Phenobarbital, CAS-RN: 50-06-6, DTXSID5021122	2 AOPs 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
803	E-4031		2 AOPs 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure
667	Diesel engine exhaust	Diesel engine exhaust, CAS-RN: NOCAS, DTXSID1024043	2 AOPs 411: Oxidative stress Leading to Decreased Lung Function 451: Interaction with lung resident cell membrane components leads to lung cancer
446	Hydralazine hydrochloride	Hydralazine hydrochloride, CAS-RN: 304-20-1, DTXSID1044645	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
467	Bisdiamine		2 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
175	PERFLUOROOCTANOIC ACID		2 AOPs 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
492	Dexamethasone	Dexamethasone, CAS-RN: 50-02-2, DTXSID3020384	2 AOPs 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
173	Raloxifene	Raloxifene, CAS-RN: 84449-90-1, DTXSID3023550	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
178	Haloperidol	Haloperidol, CAS-RN: 52-86-8, DTXSID4034150	2 AOPs 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure