Prototypical Stressors

Showing 851 to 871 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

22	Ethyl methanesulfonate	Ethyl methanesulfonate, CAS-RN: 62-50-0, DTXSID6025309	550: Increased LMNA gene mutation leading to heart failure
21	Domoic acid	L-Domoic acid, CAS-RN: 14277-97-5, DTXSID20274180	None
20	Dioxin and dioxin-like compounds	2,3,7,8-Tetrachlorodibenzo-p-dioxin, CAS-RN: 1746-01-6, DTXSID2021315 Acetamide, CAS-RN: 60-35-5, DTXSID7020005	None
19	Dimethyl sulfate	Dimethyl sulfate, CAS-RN: 77-78-1, DTXSID5024055	None
18	Dimethyl nitrosamine	N-Nitrosodimethylamine, CAS-RN: 62-75-9, DTXSID7021029	38: Protein Alkylation leading to Liver Fibrosis
17	Diethyl sulfate	Diethyl sulfate, CAS-RN: 64-67-5, DTXSID1024045	None
16	Diethyl nitrosamine	N-Nitrosodiethylamine, CAS-RN: 55-18-5, DTXSID2021028	None
15	Diclofenac sodium	Diclofenac sodium, CAS-RN: 15307-79-6, DTXSID3037208	2 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
14	Dibutyl phthalate	1,2-Benzenedicarboxylic acid, dibutyl ester, CAS-RN: 84-74-2, DTXSID2021781	4 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
13	Carbon tetrachloride	Carbon tetrachloride, CAS-RN: 56-23-5, DTXSID8020250	38: Protein Alkylation leading to Liver Fibrosis
12	Butyl 4-hydroxybenzoate	4-Hydroxybenzoic acid butyl ester, CAS-RN: 94-26-8, DTXSID3020209	None
11	Bis(2-ethylhexyl) phthalate	Di(2-ethylhexyl) phthalate, CAS-RN: 117-81-7, DTXSID5020607	2 AOPs 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
10	Benzo(k)fluoranthene	Benzo(k)fluoranthene, CAS-RN: 207-08-9, DTXSID0023909	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
9	Allyl Alcohol	Allyl alcohol, CAS-RN: 107-18-6, DTXSID8020044	38: Protein Alkylation leading to Liver Fibrosis
8	Aceytlsalicylic acid	Aspirin, CAS-RN: 50-78-2, DTXSID5020108	None
7	2-mercaptobenzothiazole	2-Mercaptobenzothiazole, CAS-RN: 149-30-4, DTXSID1020807	None
6	2(3H)-Benzothiazolethione		None
5	17beta-Trenbolone	17beta-Trenbolone, CAS-RN: 10161-33-8, DTXSID0034192	3 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 376: Androgen receptor agonism leading to male-biased sex ratio 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
4	17beta-Estradiol	17beta-Estradiol, CAS-RN: 50-28-2, DTXSID0020573	3 AOPs 314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
3	1-Methylsulfonyloxyethane	Ethyl methanesulfonate, CAS-RN: 62-50-0, DTXSID6025309	None
2	(2-ethylhexyl) hydrogen phthalate	MEHP, CAS-RN: 4376-20-9, DTXSID2025680	None