Prototypical Stressors

Showing 76 to 100 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

173	Raloxifene	Raloxifene, CAS-RN: 84449-90-1, DTXSID3023550	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
175	PERFLUOROOCTANOIC ACID		2 AOPs 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
178	Haloperidol	Haloperidol, CAS-RN: 52-86-8, DTXSID4034150	2 AOPs 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
453	Other DNA damaging agents		2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
449	Temozolomide	Temozolomide, CAS-RN: 85622-93-1, DTXSID5043714	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
448	RG 108		2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
447	Zebularine		2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
446	Hydralazine hydrochloride	Hydralazine hydrochloride, CAS-RN: 304-20-1, DTXSID1044645	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
445	Psammaplin A		2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
342	Trichostatin A	Trichostatin A, CAS-RN: 58880-19-6, DTXSID6037063	2 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 274: Histone deacetylase inhibition leads to impeded craniofacial development
255	Graphene oxide nanoparticles		2 AOPs 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
256	Polychlorinated dibenzodioxins		2 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
367	Diuron	Diuron, CAS-RN: 330-54-1, DTXSID0020446	2 AOPs 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
261	Tetrabromobisphenol A	3,3',5,5'-Tetrabromobisphenol A, CAS-RN: 79-94-7, DTXSID1026081	2 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
360	Ethanol	Ethanol, CAS-RN: 64-17-5, DTXSID9020584	2 AOPs 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
284	Aristolochic acid	Aristolochic acid, CAS-RN: 313-67-7, DTXSID0040969	2 AOPs 397: Bulky DNA adducts leading to mutations 644: Bulky DNA adducts leading to chromosomal aberrations and mutations
761	Tian Ma (Tall Gastrodia Tuber)		2 AOPs 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function
749	Titanium dioxide nanoparticles		2 AOPs 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 451: Interaction with lung resident cell membrane components leads to lung cancer
758	3,3′,5,5′ tetrabromobisphenol A		2 AOPs 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition
345	Endosulfan	Endosulfan, CAS-RN: 115-29-7, DTXSID1020560	2 AOPs 10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
319	Acrolein	Acrolein, CAS-RN: 107-02-8, DTXSID5020023	2 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
304	Tributyltin	Tributyltin, CAS-RN: 688-73-3, DTXSID0040709	2 AOPs 72: Epigenetic modification of PPARG leading to adipogenesis 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
310	Disulfiram	Tetraethylthiuram disulfide, CAS-RN: 97-77-8, DTXSID1021322	2 AOPs 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
300	PPARalpha antagonists		2 AOPs 6: Antagonist binding to PPARα leading to body-weight loss 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
321	3,5-Dichlorophenol	3,5-Dichlorophenol, CAS-RN: 591-35-5, DTXSID2025006	2 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation