Prototypical Stressors

Showing 126 to 150 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

128	Benomyl	Benomyl, CAS-RN: 17804-35-2, DTXSID5023900	2 AOPs 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
638	(-)-Epigallocatechin gallate	(-)-Epigallocatechin gallate, CAS-RN: 989-51-5, DTXSID1029889	2 AOPs 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response 486: Binding to the extracellular protein laminin leading to decreased cognitive function
603	Triclosan	Triclosan, CAS-RN: 3380-34-5, DTXSID5032498	2 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
32	Letrozole	Letrozole, CAS-RN: 112809-51-5, DTXSID4023202 Fadrozole, CAS-RN: 102676-47-1, DTXSID5034141	2 AOPs 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
74	2,2',4,4'-Tetrahydroxybenzophenone	2,2',4,4'-Tetrahydroxybenzophenone, CAS-RN: 131-55-5, DTXSID5041306	2 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
620	HCoV-NL63		2 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
655	Ozone	Ozone, CAS-RN: 10028-15-6, DTXSID0021098	2 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
50	Rotenone	Rotenone, CAS-RN: 83-79-4, DTXSID6021248	2 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation
651	Ethyl Parathion		2 AOPs 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
649	Paraoxon	Paraoxon, CAS-RN: 311-45-5, DTXSID6024046	2 AOPs 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
868	Acenaphthene	Acenaphthene, CAS-RN: 83-32-9, DTXSID3021774	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
869	Acenaphthylene	Acenaphthylene, CAS-RN: 208-96-8, DTXSID3023845	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
634	nanomaterials		2 AOPs 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 451: Interaction with lung resident cell membrane components leads to lung cancer
15	Diclofenac sodium	Diclofenac sodium, CAS-RN: 15307-79-6, DTXSID3037208	2 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
546	Malathion	Malathion, CAS-RN: 121-75-5, DTXSID4020791	2 AOPs 551: Increased Muscarinic M2 Receptor leading to Arrhythmia 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
870	Fluorene	Fluorene, CAS-RN: 86-73-7, DTXSID8024105	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
11	Bis(2-ethylhexyl) phthalate	Di(2-ethylhexyl) phthalate, CAS-RN: 117-81-7, DTXSID5020607	2 AOPs 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
10	Benzo(k)fluoranthene	Benzo(k)fluoranthene, CAS-RN: 207-08-9, DTXSID0023909	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
548	Triphenyl phosphate	Triphenyl phosphate, CAS-RN: 115-86-6, DTXSID1021952	2 AOPs 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
872	Indeno(1,2,3-cd)pyrene	Indeno(1,2,3-cd)pyrene, CAS-RN: 193-39-5, DTXSID8024153	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
118	Verapamil	(+/-)-Verapamil, CAS-RN: 52-53-9, DTXSID9041152	2 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
873	Dibenz(a,h)anthracene	Dibenz(a,h)anthracene, CAS-RN: 53-70-3, DTXSID9020409	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
35	Mercuric chloride	Mercuric chloride, CAS-RN: 7487-94-7, DTXSID5020811	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
871	Fluoranthene	Fluoranthene, CAS-RN: 206-44-0, DTXSID3024104	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
83	Emamectin benzoate	Emamectin benzoate, CAS-RN: 155569-91-8, DTXSID0034566	2 AOPs 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality