Prototypical Stressors

Showing 151 to 175 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

655	Ozone	Ozone, CAS-RN: 10028-15-6, DTXSID0021098	2 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
620	HCoV-NL63		2 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
74	2,2',4,4'-Tetrahydroxybenzophenone	2,2',4,4'-Tetrahydroxybenzophenone, CAS-RN: 131-55-5, DTXSID5041306	2 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
32	Letrozole	Letrozole, CAS-RN: 112809-51-5, DTXSID4023202 Fadrozole, CAS-RN: 102676-47-1, DTXSID5034141	2 AOPs 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
603	Triclosan	Triclosan, CAS-RN: 3380-34-5, DTXSID5032498	2 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
593	Polyoxin D		360: Chitin synthase 1 inhibition leading to mortality
599	Stressor:292 Clotrimazole		346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
744	Oxyclozanide	Oxyclozanide, CAS-RN: 2277-92-1, DTXSID50177312	263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
743	Niclosamide ethanolamine		263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
742	DCPMU		335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
741	DCA		335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
598	Exemestane	Exemestane, CAS-RN: 107868-30-4, DTXSID5023037	346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
740	Carbon black	Carbon black, CAS-RN: 1333-86-4, DTXSID7051216	451: Interaction with lung resident cell membrane components leads to lung cancer
739	welding fumes		451: Interaction with lung resident cell membrane components leads to lung cancer
621	DX600		319: Binding to ACE2 leading to lung fibrosis
368	Nikkomycins	Nikkomycins, CAS-RN: 59456-70-1, DTXSID5058436	360: Chitin synthase 1 inhibition leading to mortality
596	Folpet	Folpet, CAS-RN: 133-07-3, DTXSID0021385	360: Chitin synthase 1 inhibition leading to mortality
732	Vitamin A		436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
585	PF-06651600 (CAS No：1792180-81-4),		315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
628	cell free mitochondrial DNA (mtDNA)		377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
629	unmethylated CpG motifs (DNA;RNA;ODN)		377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
630	Chemical:33664 17-Methyltestosterone		376: Androgen receptor agonism leading to male-biased sex ratio
631	Danger Associated Molecular Patters (DAMPs)		377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
579	PF915275		348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
575	Lysodren, Mitotan, Mitotane	Lysodren, Mitotan, Mitotane, CAS-RN: 164203-73-0, DTXSID30425146	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory