Prototypical Stressors

Showing 176 to 200 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

738	Uranium, soluble salts	Uranium, soluble salts, CAS-RN: NOCAS, DTXSID7024374	447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
369	Polyoxin B	Polyoxin B, CAS-RN: 19396-06-6, DTXSID3058329	360: Chitin synthase 1 inhibition leading to mortality
594	Captafol	Captafol, CAS-RN: 2425-06-1, DTXSID4020242	360: Chitin synthase 1 inhibition leading to mortality
595	Captan	Captan, CAS-RN: 133-06-2, DTXSID9020243	360: Chitin synthase 1 inhibition leading to mortality
596	Folpet	Folpet, CAS-RN: 133-07-3, DTXSID0021385	360: Chitin synthase 1 inhibition leading to mortality
368	Nikkomycins	Nikkomycins, CAS-RN: 59456-70-1, DTXSID5058436	360: Chitin synthase 1 inhibition leading to mortality
621	DX600		319: Binding to ACE2 leading to lung fibrosis
739	welding fumes		451: Interaction with lung resident cell membrane components leads to lung cancer
740	Carbon black	Carbon black, CAS-RN: 1333-86-4, DTXSID7051216	451: Interaction with lung resident cell membrane components leads to lung cancer
598	Exemestane	Exemestane, CAS-RN: 107868-30-4, DTXSID5023037	346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
741	DCA		335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
742	DCPMU		335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
743	Niclosamide ethanolamine		263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
744	Oxyclozanide	Oxyclozanide, CAS-RN: 2277-92-1, DTXSID50177312	263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
599	Stressor:292 Clotrimazole		346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
334	low molecular weight proteins		257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
331	Polymyxin B	Polymyxin B, CAS-RN: 1404-26-8, DTXSID1048467	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
332	Colistin	Colistin, CAS-RN: 1066-17-7, DTXSID1040663	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
333	Albumin	Albumin, CAS-RN: 308060-74-4, DTXSID1040409	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
616	TAK-242		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
612	curcumin	Curcumin, CAS-RN: 458-37-7, DTXSID8031077	277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
611	Pralnacasan (VX-740, HMR3480)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
340	Methoxyacetic acid	Methoxyacetic acid, CAS-RN: 625-45-6, DTXSID1031591	212: Histone deacetylase inhibition leading to testicular atrophy
330	Vancomycin	Vancomycin, CAS-RN: 1404-90-6, DTXSID0042664	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
336	Acrylamide	Acrylamide, CAS-RN: 79-06-1, DTXSID5020027	17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory