Prototypical Stressors

Showing 201 to 225 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

330	Vancomycin	Vancomycin, CAS-RN: 1404-90-6, DTXSID0042664	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
331	Polymyxin B	Polymyxin B, CAS-RN: 1404-26-8, DTXSID1048467	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
332	Colistin	Colistin, CAS-RN: 1066-17-7, DTXSID1040663	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
333	Albumin	Albumin, CAS-RN: 308060-74-4, DTXSID1040409	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
616	TAK-242		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
334	low molecular weight proteins		257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
336	Acrylamide	Acrylamide, CAS-RN: 79-06-1, DTXSID5020027	17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
612	curcumin	Curcumin, CAS-RN: 458-37-7, DTXSID8031077	277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
340	Methoxyacetic acid	Methoxyacetic acid, CAS-RN: 625-45-6, DTXSID1031591	212: Histone deacetylase inhibition leading to testicular atrophy
611	Pralnacasan (VX-740, HMR3480)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
351	Halothane	Halothane, CAS-RN: 151-67-7, DTXSID4025371	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
358	Isoniazid	Isoniazid, CAS-RN: 54-85-3, DTXSID8020755	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
357	Titanium oxide (TiO)	Titanium oxide (TiO), CAS-RN: 12137-20-1, DTXSID7065253	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
600	Pentachlorophenol	Pentachlorophenol, CAS-RN: 87-86-5, DTXSID7021106	263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
356	Chlorzoxazone	Chlorzoxazone, CAS-RN: 95-25-0, DTXSID9022813	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
601	Carbonyl cyanide-p-trifluoromethoxyphenylhydrazone		263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
355	Chemical:584015 (1-~13~C)Aniline		260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
354	Sevoflurane	Sevoflurane, CAS-RN: 28523-86-6, DTXSID8046614	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
353	Methoxyflurane	Methoxyflurane, CAS-RN: 76-38-0, DTXSID7025556	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
352	Isoflurane	Isoflurane, CAS-RN: 26675-46-7, DTXSID3020752	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
344	Heptachlor	Heptachlor, CAS-RN: 76-44-8, DTXSID3020679	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
605	Emodin	Emodin, CAS-RN: 518-82-1, DTXSID5025231	263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
609	Belnacasan (VX-765)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
747	Toluene diisocyanate	Toluene diisocyanate, CAS-RN: 26471-62-5, DTXSID0024341	39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
750	Iron nanoparticles		392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation