Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 226 to 250 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
684 abnormal embryo development (GO:0009790) 1295: Defect of Embryogenesis
694 increased cell activation involved in immune response (GO:0002263) 1492: Tissue resident cell activation
695 increased acute inflammatory response (GO:0002526) 1493: Increased Pro-inflammatory mediators
705 decreased fatty acid beta-oxidation (GO:0006635) 1528: Fatty Acid Beta Oxidation, Decreased
713 decreased abnormal circulating hormone level (MP:0005418) None
714 increased cellular response to oxidative stress (GO:0034599) 1394: Induction, persistent proliferation/sustained proliferation
719 increased hypoxia-inducible factor-1alpha signaling pathway (GO:0097411) None
260 occurrence inflammatory response (GO:0006954) 486: systemic inflammation leading to hepatic steatosis
262 decreased ovulation (GO:0030728) 488: Decrease, Ovulation
264 decreased reproductive process (GO:0022414) 675: Reduced, Reproductive Success
266 increased apoptotic process (GO:0006915)
267 decreased sperm quantity (VT:0002673) 520: Decreased sperm quantity or quality in the adult, Decreased fertility
270 abnormal abnormal nervous system physiology (MP:0003633) 192: Altered, Neurophysiology
273 increased abnormal fetal Leydig cell differentiation (MP:0013603)
274 increased Testicular dysgenesis (HP:0008715)
276 increased abnormal adult Leydig cell differentiation (MP:0013604) 541: Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells
283 decreased steroid biosynthetic process (GO:0006694) 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
284 decreased regulation of steroid biosynthetic process (GO:0050810) 647: Decreased, steroidogenic protein expression
289 abnormal regulation of steroid biosynthetic process (GO:0050810) 652: Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
295 delayed abnormal ovulation (MP:0001928) 532: Delayed, Ovulation
298 abnormal sperm entry (GO:0035037) 535: Abnormal, Sperm penetration (polyspermy)
299 increased abnormal chromosome number (MP:0004023)
300 increased DNA hypermethylation (GO:0044026) 662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
302 abnormal foraging behavior (GO:0060756) 560: Abnormal, Foraging activity and behavior
303 increased colony collapse (MESH:D056631)