Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 226 to 250 of 1147 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


285	increased	apoptotic process (GO:0006915)	Leydig cell (CL:0000178)	648: Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells
820	decreased	apoptotic process (GO:0006915)	ciliated epithelial cell (CL:0000067)	914: Decrease, Apoptosis of ciliated epithelial cells
207	decreased	apoptotic process (GO:0006915)		2 Events 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis 1183: Decreased, Apoptosis (Epithelial Cells)
314	increased	Appetite (MESH:D001066)		574: Increased, Appetite and hunger
327	decreased	aquatic locomotion (NBO:0000371)		2 Events 586: Reduced, swimming speed 1005: Reduced, Swimming performance
423	decreased	aromatase activity (GO:0070330)	aromatase isoform 1 (PR:000038849)	800: Decreased, Aromatase (Cyp19a1) mRNA
32	decreased	aromatase activity (GO:0070330)	aromatase (PR:000006100)	3 Events 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) 36: Inhibition, Aromatase 800: Decreased, Aromatase (Cyp19a1) mRNA
1083	increased	aromatase activity (GO:0070330)	aromatase (PR:000006100)	2293: Aromatase, induction
361	increased	Arrhythmias, Cardiac (MESH:D001145)		699: Increased, cardiac arrthymia
101	increased	aryl hydrocarbon receptor activity (GO:0004874)	aryl hydrocarbon receptor (PR:000003858)	18: Activation, AhR
1073	increased	aryl hydrocarbon receptor binding (GO:0017162)	aryl hydrocarbon receptor (PR:000003858)	18: Activation, AhR
80	increased	ataxia (MP:0001393)		3 Events 39: Increased Cholinergic Signaling 602: Increased, Ataxia, paralysis, or hyperactivity 764: N/A, Ataxia, paralysis, or hyperactivity
942	increased	Atherosclerosis (HP:0002621)		1443: Atherosclerosis
119	decreased	ATP biosynthetic process (GO:0006754)	ATP (CHEBI:15422)	4 Events 40: Mitochondrial ATP production, decreased 1138: Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP 1771: Decrease, Adenosine triphosphate pool 1472: Decrease, ATP production
796	decreased	ATP synthesis coupled proton transport (GO:0015986)	mitochondrion (GO:0005739)	None
460	increased	atrophy (MESH:D001284)	olfactory epithelium (UBERON:0001997)	868: Increase, Tissue Degeneration, Necrosis & Atrophy
349	decreased	attraction-related behavior (NBO:0000280)		674: Reduced, Ability to attract spawning mates
443	occurrence	autophagic cell death (GO:0048102)	renal tubule (UBERON:0009773)	818: Occurrence, Cytoplasmic vacuolization (Renal tubule)
450	occurrence	autophagic cell death (GO:0048102)		4 Events 833: Occurrence, Cytoplasmic vacuolization (hepatocyte) 835: Occurrence, Ballooning degeneration (hepatocyte) 836: Occurrence, Cytoplasmic vacuolization (Bile duct cell) 837: Occurrence, Cytoplasmic vacuolization (kupffer cell)
1058	occurrence	B cell activation involved in immune response (GO:0002312)	B cell (CL:0000236)	2256: Gluten-reactive B cells and transglutaminase 2-reactive B cells, activation
1072	abnormal	behavior (GO:0007610)		2301: Abnormal, Behavior
538	increased	beta-2 adrenergic receptor binding (GO:0031698)	beta-2 adrenergic receptor (PR:000001193)	1038: Activation, beta-2 adrenergic receptor
539	increased	beta2-adrenergic receptor activity (GO:0004941)	beta-2 adrenergic receptor (PR:000001193)	1039: Increased activity, beta-2 adrenergic receptor
133	decreased	bicarbonate transport (GO:0015701)	hydrogencarbonate (CHEBI:17544)	49: Reduction, Ca and HCO3 transport to shell gland
304	abnormal	binding (GO:0005488)	calcium ion (CHEBI:39124)	1243: Altered, Ca2+-calmodulin activated signal transduction