Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 251 to 275 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
370 increased binding (GO:0005488) major urinary protein (rat) (PR:P02761) 714: Increased, Binding of chemicals to 2u (serum)
503 increased binding (GO:0005488) transthyretin (PR:000016801) 957: Binding, Transthyretin in serum
515 increased binding (GO:0005488) FK506-binding protein 15 (PR:000007535) 980: Inhibition, Calcineurin Activity
516 increased binding (GO:0005488) FKBP12 (Arabidopsis thaliana) (TAIR:AT5G64350) 980: Inhibition, Calcineurin Activity
517 increased binding (GO:0005488) Immunophilins (MESH:D020104) 1201: Binding, Immunophilins
483 decreased biosynthetic process (GO:0009058) 5,6,7,8-tetrahydrobiopterin (CHEBI:15372) 934: KE3 : Decrease, Tetrahydrobiopterin
667 increased biosynthetic process (GO:0009058) reactive oxygen species (CHEBI:26523) None
253 increased biosynthetic process (GO:0009058) triglyceride (CHEBI:17855)
221 decreased blood circulation (GO:0008015) blood (UBERON:0000178) 298: Insufficiency, Vascular
1018 decreased blood circulation (GO:0008015) blood plasma (UBERON:0001969) 2261: Decreased, blood plasma volume
915 increased blood coagulation, fibrin clot formation (GO:0072378) Fibrin (CHEBI:5054) 1846: Thrombosis and Disseminated Intravascular Coagulation
900 occurrence blood vessel remodeling (GO:0001974) blood vessel (UBERON:0001981) 2069: Occurrence, Abnormal Vascular Remodeling
989 increased blood viscosity trait (VT:3000004) blood (UBERON:0000178) 2238: Increased, Blood viscosity
1001 decreased bone mineralization (GO:0030282) 2090: Increase, Bone Remodeling
707 morphological change brain development (GO:0007420) hippocampal formation (UBERON:0002421) 757: Hippocampal anatomy, Altered
8 pathological brain inflammation (MP:0001847) microglial cell (CL:0000129) 188: Neuroinflammation
9 pathological brain inflammation (MP:0001847) astrocyte (CL:0000127) 188: Neuroinflammation
958 increased Breast carcinoma (HP:0003002) VEGF-A complex (GO:1990150) 1376: Increase, angiogenesis
959 increased Breast carcinoma (HP:0003002) BRCA1-A complex (GO:0070531) 1971: Increased, tumor growth
922 increased calcium amount (VT:0010499) calcium(2+) (CHEBI:29108) 1339: Increase, intracellular calcium
54 decreased calcium ion transport (GO:0006816) calcium ion (CHEBI:39124)
615 increased calcium ion transport (GO:0006816) calcium ion (CHEBI:39124)
116 decreased calcium-transporting ATPase activity (GO:0005388) calcium ion-transporting ATPase complex (GO:0090534) 51: Inhibition, Ca++ ATPase
321 abnormal calmodulin binding (GO:0005516) calcium ion (CHEBI:39124) 1243: Altered, Ca2+-calmodulin activated signal transduction
582 decreased carboxylation reaction (MI:1139) prothrombin (PR:000007299) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)