Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 276 to 300 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
35 decreased fertility (MESH:D005298) 406: decreased, Fertility
41 decreased thyroxine (CHEBI:30660)
49 decreased GABA-gated chloride ion channel activity (GO:0022851) chloride (CHEBI:17996)
51 decreased chemical synaptic transmission (GO:0007268) 669: Reduction, Neuronal synaptic inhibition
54 decreased calcium ion transport (GO:0006816) calcium ion (CHEBI:39124)
55 decreased gene expression (GO:0010467) brain-derived neurotrophic factor (PR:000004716) 381: Reduced levels of BDNF
56 decreased secretion (GO:0046903) brain-derived neurotrophic factor (PR:000004716) 381: Reduced levels of BDNF
59 decreased learning (GO:0007612) 341: Impairment, Learning and memory
61 decreased glutamate secretion, neurotransmission (GO:0061535) glutamate(1-) (CHEBI:14321) None
62 decreased synapse assembly (GO:0007416) synapse (GO:0045202) 385: Decrease of synaptogenesis
63 decreased synaptic signaling (GO:0099536)
64 decreased memory (GO:0007613) 341: Impairment, Learning and memory
66 decreased I-kappaB kinase/NF-kappaB signaling (GO:0007249) transcription factor NF-kappa-B subunit (PR:000001753) 202: Inhibition, Nuclear factor kappa B (NF-kB)
67 decreased cytokine production involved in inflammatory response (GO:0002534) 152: Suppression, Inflammatory cytokines
68 decreased lymphocyte (CL:0000542) 168: Decreased, Lymphocytes
75 decreased acetylcholinesterase activity (GO:0003990) acetylcholinesterase (PR:000003626) 12: Acetylcholinesterase (AchE) Inhibition
83 decreased population growth rate (PCO:0000008)
86 decreased glutathione (CHEBI:16856) None
90 decreased gene expression (GO:0010467) STAR (PR:000015715) 266: Decrease, Steroidogenic acute regulatory protein (STAR)
91 decreased gene expression (GO:0010467) translocator protein (PR:000016757) 289: Decrease, Translocator protein (TSPO)
92 decreased mitochondrial transport (GO:0006839) cholesterol (CHEBI:16113) 447: Reduction, Cholesterol transport in mitochondria
93 decreased testosterone biosynthetic process (GO:0061370) testosterone (CHEBI:17347)
94 decreased testosterone (CHEBI:17347)
96 decreased androgen receptor activity (GO:0004882) androgen receptor (PR:000004191)
99 decreased regulation of gene expression (GO:0010468) androgen receptor (PR:000004191) 286: Altered, Transcription of genes by the androgen receptor