Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 276 to 300 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
356 decreased G2/MI transition of meiotic cell cycle (GO:0008315) 694: Reduced, Meiotic prophase I/metaphase I transition, oocyte
357 abnormal chromosome segregation (GO:0007059) 696: Increased, Chromosome misseggregation
360 abnormal action potential (GO:0001508) 698: Altered, Action Potential
361 increased Arrhythmias, Cardiac (MESH:D001145) 699: Increased, cardiac arrthymia
377 abnormal regulation of gene expression (GO:0010468) 1214: Altered gene expression specific to CAR activation, Hepatocytes
378 increased cellular respiration (GO:0045333) 769: Increase, Oxidative metabolism
391 increased neoplasm (MP:0002006) 745: Increase, Leydig cell tumors
395 increased synaptic transmission, dopaminergic (GO:0001963) 746: Increase, Dopaminergic activity
400 increased membrane hyperpolarization (GO:0060081) 763: hyperpolarisation, neuron
436 decreased glomerular filtration (GO:0003094) 819: Decreased, Glomerular filtration
437 decreased kidney plasma flow trait (VT:0005524) 820: Decreased, Renal plasma flow
441 increased abnormal amino acid level (MP:0005332) 813: Increased, Serum creatinine
445 occurrence podocyte vacuolization (MP:0011899) 824: Occurrence, Cytoplasmic vacuolization (podocyte)
447 occurrence Mallory bodies (MP:0014045) 839: Formation, Mallory body
448 increased Microvesicular hepatic steatosis (HP:0001414) 838: Induction, Microvesicular fat
450 occurrence autophagic cell death (GO:0048102)
456 increased porphyria (MP:0005654) 369: Uroporphyria
458 decreased regulation of intracellular pH (GO:0051453) 867: Decrease, Intracellular pH
459 increased leukocyte mediated cytotoxicity (GO:0001909) 768: Increase, Cytotoxicity
461 increased necrotic cell death (GO:0070265)
466 occurrence renal tubular necrosis (MP:0004154) 1097: Occurrence, renal proximal tubular necrosis
471 occurrence liver inflammation (MP:0001860) 902: Inflammation, Liver
474 decreased epithelial cell apoptotic process (GO:1904019) None
481 decreased respiratory function trait (VT:0002327) 1250: Decrease, Lung function
482 occurrence mucus secretion (GO:0070254) None