Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 276 to 300 of 1150 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
243 increased gene expression (GO:0010467) cytochrome P450 1A1 (PR:000006101) 80: Up Regulation, CYP1A1
244 decreased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 456: Suppression, Constitutive androstane receptor, NR1I3
245 increased signaling (GO:0023052) sterol regulatory element-binding protein 1 (PR:000015611) 457: Activation, SREBF1
246 increased triglyceride biosynthetic process (GO:0019432) triglyceride (CHEBI:17855) 454: Increased, Triglyceride formation
247 increased gene expression (GO:0010467) fatty acid synthase (PR:000007348) 463: Up Regulation, FAS
248 increased acetyl-CoA carboxylase activity (GO:0003989) acetyl-CoA carboxylase 1 (PR:000003596) 470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
249 decreased signaling (GO:0023052) hepatocyte nuclear factor 4-alpha (PR:000008654) 461: Suppression, HNF4alpha
250 decreased signaling (GO:0023052) hepatocyte nuclear factor 3-beta (PR:000007603) 471: Inhibition, FoxA2
251 decreased gene expression (GO:0010467) carnitine O-palmitoyltransferase 1, liver isoform (PR:000005835) 472: Down Regulation, CPT1A
252 decreased gene expression (GO:0010467) hydroxymethylglutaryl-CoA synthase, mitochondrial (PR:000008638) 474: Down Regulation, HMGCS2
254 increased signaling (GO:0023052) nuclear factor erythroid 2-related factor 2 (PR:000011170) 478: Activation, NRF2
255 increased signaling (GO:0023052) bile acid receptor (PR:000011396) 479: Activation, NR1H4
282 decreased intracellular cholesterol transport (GO:0032367) cholesterol (CHEBI:16113) 644: Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
1150 increased Abnormality of cellular immune system (HP:0010987) B7-related protein (PR:000001290) 2323: Over-expression of PD-L1 in cancer cells
288 abnormal glucocorticoid receptor activity (GO:0004883) glucocorticoid receptor (PR:000011406) 651: Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells
289 abnormal regulation of steroid biosynthetic process (GO:0050810) 652: Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
290 decreased dopamine beta-monooxygenase activity (GO:0004500) dopamine beta-hydroxylase (PR:000006294) 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase
291 decreased norepinephrine biosynthetic process (GO:0042421) (R)-noradrenaline (CHEBI:18357) 528: Decreased, Synthesis of NE
292 decreased signaling (GO:0023052) proto-oncogene c-Fos (mouse) (PR:P01101) 529: Decreased, GnRH cfos activity
294 decreased regulation of luteinizing hormone secretion (GO:0033684) Luteinizing hormone (CHEBI:81568) 531: Decreased, LH Surge
295 delayed abnormal ovulation (MP:0001928) 532: Delayed, Ovulation
296 decreased secretion (GO:0046903) cortical granule (GO:0060473) 533: Decreased, Cortical granule release/distribution upon fertilization
297 abnormal fertilization envelope (GO:0060387) 534: Altered, Formation of cortical envelope
298 abnormal sperm entry (GO:0035037) 535: Abnormal, Sperm penetration (polyspermy)
300 increased DNA hypermethylation (GO:0044026) 662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis