Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 276 to 300 of 1152 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
463 increased neoplasm (MP:0002006) olfactory segment of nasal mucosa (UBERON:0005386) 872: Increase, Site of Contact Nasal Tumors
460 increased atrophy (MESH:D001284) olfactory epithelium (UBERON:0001997) 868: Increase, Tissue Degeneration, Necrosis & Atrophy
586 decreased transport (GO:0006810) nutrient (CHEBI:33284) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
244 decreased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 456: Suppression, Constitutive androstane receptor, NR1I3
38 increased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 715: Activation, Constitutive androstane receptor
37 increased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 2 (PR:000011397)
256 increased signaling (GO:0023052) nuclear receptor subfamily 0 group B member 2 (PR:000011391) 480: Activation, SHP
23 increased transcription corepressor activity (GO:0003714) nuclear receptor corepressor 2 (PR:000011048) 1000: stabilization, PPAR alpha co-repressor
24 increased transcription corepressor activity (GO:0003714) nuclear receptor corepressor 1 (PR:000011047) 1000: stabilization, PPAR alpha co-repressor
18 increased gene expression (GO:0010467) nuclear hormone receptor FTZ-F1 (fruit fly) (PR:P33244) 1265: Decrease, Fushi tarazu factor-1 gene expression
254 increased signaling (GO:0023052) nuclear factor erythroid 2-related factor 2 (PR:000011170) 478: Activation, NRF2
224 abnormal DNA alkylation (GO:0006305) Nuclear deoxyribonucleic acid (FMA:67194) 373: Formation, Pro-mutagenic DNA Adducts
228 functional change DNA repair (GO:0006281) Nuclear deoxyribonucleic acid (FMA:67194) 493: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts
1085 increased wounding (MP:0013027) Nose (FMA:46472) 2312: Increased, nasal lesions
1090 decreased response to odorant (GO:1990834) Nose (FMA:46472) 2317: Loss of olfactory function
685 decreased NMDA glutamate receptor activity (GO:0004972) NMDA selective glutamate receptor complex (GO:0017146) 195: Inhibition, NMDARs
686 increased NMDA glutamate receptor activity (GO:0004972) NMDA selective glutamate receptor complex (GO:0017146) 388: Overactivation, NMDARs
806 increased NLRP3 inflammasome complex assembly (GO:0044546) NLRP3 inflammasome complex (GO:0072559) 1895: NLRP3 inflammasome activity, increased
485 decreased catalytic activity (GO:0003824) nitric oxide synthase, endothelial (PR:000011328) 973: KE5 : Decrease, AKT/eNOS activity
492 increased protein glutathionylation (GO:0010731) nitric oxide synthase, endothelial (PR:000011328) 927: KE1 : S-Glutathionylation, eNOS
494 functional change nitric oxide synthase, endothelial (PR:000011328) 932: KE4 : Uncoupling, eNOS
160 decreased nitric-oxide synthase activity (GO:0004517) nitric oxide synthase, brain (PR:000011326) 147: Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307
121 decreased nitric oxide (CHEBI:16480) 193: Decreased, Nitric Oxide
487 decreased nitric oxide biosynthetic process (GO:0006809) nitric oxide (CHEBI:16480) 933: KE6 : Depletion, Nitric Oxide
301 increased acetylcholine receptor activity (GO:0015464) Nicotinic acetylcholine receptor (FMA:61796) 559: Activation, Nicotinic acetylcholine receptor