Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 301 to 325 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
100 decreased fertility (MESH:D005298)
108 decreased gene expression (GO:0010467) vitellogenins (MESH:D014819) 285: Reduction, Vitellogenin synthesis in liver
109 decreased egg quantity (VT:1000294)
110 decreased vitellogenins (MESH:D014819) 221: Reduction, Plasma vitellogenin concentrations
111 decreased receptor-mediated endocytosis (GO:0006898) vitellogenins (MESH:D014819) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
112 decreased oocyte growth (GO:0001555) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
113 decreased oocyte development (GO:0048599) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
114 decreased Luteinizing hormone (CHEBI:81568)
115 decreased Follicle stimulating hormone (CHEBI:81569) 129: Reduction, Gonadotropins, circulating concentrations
116 decreased calcium-transporting ATPase activity (GO:0005388) calcium ion-transporting ATPase complex (GO:0090534) 51: Inhibition, Ca++ ATPase
119 decreased ATP biosynthetic process (GO:0006754) ATP (CHEBI:15422)
121 decreased nitric oxide (CHEBI:16480) 193: Decreased, Nitric Oxide
122 decreased long-term synaptic potentiation (GO:0060291) 166: Decreased, Long-term potentiation (LTP)
124 decreased transport (GO:0006810) bile salt export pump (PR:000003549) 41: Inhibition, Bile Salt Export Pump (ABCB11)
130 decreased prostaglandin-endoperoxide synthase activity (GO:0004666) prostaglandin G/H synthase 1 (PR:000013427)
131 decreased prostaglandin-endoperoxide synthase activity (GO:0004666) prostaglandin G/H synthase 2 (PR:000013428) 79: Inhibition, Cyclooxygenase activity
132 decreased prostaglandin E2 (CHEBI:15551)
133 decreased bicarbonate transport (GO:0015701) hydrogencarbonate (CHEBI:17544) 49: Reduction, Ca and HCO3 transport to shell gland
134 decreased eggshell (UBERON:0005079) 106: Reduction, Eggshell thickness
144 decreased estrogen receptor activity (GO:0030284) estrogen receptor (PR:000007204)
150 decreased gene expression (GO:0010467) glucose-6-phosphate 1-dehydrogenase (PR:000007749) 131: Down Regulation, Gulcose-6-phosphate dehydrogenase
155 decreased hemoglobin (CHEBI:35143) 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
159 decreased Decreased liver function (HP:0001410) 164: Induction, Liver “Dysfunctional” Changes by CGA 330050
160 decreased nitric-oxide synthase activity (GO:0004517) nitric oxide synthase, brain (PR:000011326) 147: Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307
181 decreased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor alpha (PR:000013056)