Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 326 to 350 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
407 increased cell death (GO:0008219) epithelial cell (CL:0000066) 780: Increase, Cytotoxicity (epithelial cells)
409 increased stomach epithelial hyperplasia (MP:0005493) epithelial cell (CL:0000066) 782: Increase, Hyperplasia (forestomach epithelial cells)
326 decreased action potential (GO:0001508) 585: Decreased, Sodium conductance 1
410 increased Carcinoma, Renal Cell (MESH:D002292) Adenoma (MESH:D000236) 713: Increase, Adenomas/carcinomas (renal tubular)
329 increased Amputation, Congenital (MESH:C565682) 591: Increased, amputations
330 decreased hypoxia (MP:0005039) 590: N/A, hypoxia
331 decreased potassium channel inhibitor activity (GO:0019870) potassium voltage-gated channel subfamily H member 2 (human) (PR:Q12809) 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
332 increased neurotransmitter secretion (GO:0007269) 600: Overactivation, Neuronotransmitter release
333 increased membrane depolarization (GO:0051899) 599: prolonged, Depolarization of neuronal membrane
334 increased locomotion (GO:0040011) 622: Increased, locomotion
335 increased fossorial locomotion behavior (NBO:0000071) 624: Increased, foot detachment
336 decreased neurotransmitter reuptake (GO:0098810) sodium-dependent serotonin transporter (PR:000015189) 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
337 increased musculoskeletal movement (GO:0050881) valve (UBERON:0003978) 1142: Increased, valve movement
338 decreased serotonin secretion (GO:0001820) sodium-dependent serotonin transporter (PR:000015189) 626: Increased, serotonin (5-HT)
339 decreased fear/anxiety related behavior (NBO:0000018) 627: Decreased, anxiety
340 decreased abnormal sheltering behavior (MP:0014039) 629: Decreased, sheltering
341 decreased serotonin uptake (GO:0051610) sodium-dependent serotonin transporter (PR:000015189) 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
342 decreased histamine receptor activity (GO:0004969) histamine H2 receptor (PR:000001423) 638: Antagonism, Histamine Receptor (H2)
343 decreased rhythmic excitation (GO:0043179) histaminergic neuron (CL:0011110) 633: Decrease, histaminergic neuron excitation
344 decreased locomotion (GO:0040011) 635: Decreased, locomotion
345 increased anesthesia (MESH:D000758) 634: N/A, sedation
415 increased cell proliferation (GO:0008283) hepatocyte (CL:0000182) 787: Increase, Regenerative cell proliferation (hepatocytes)
348 abnormal fertility (MESH:D005298) 673: Reduced, Spawning behavior
349 decreased attraction-related behavior (NBO:0000280) 674: Reduced, Ability to attract spawning mates
412 increased kidney epithelium hyperplasia (MP:0004968) nephron tubule epithelial cell (CL:1000494) 784: Increase, Hyperplasia (tubular epithelial cells)