Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 326 to 350 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
483 decreased biosynthetic process (GO:0009058) 5,6,7,8-tetrahydrobiopterin (CHEBI:15372) 934: KE3 : Decrease, Tetrahydrobiopterin
376 increased preneoplasia (MP:0002009) abnormal cell mass (MP:0003902) 774: Increase, Preneoplastic foci (hepatocytes)
248 increased acetyl-CoA carboxylase activity (GO:0003989) acetyl-CoA carboxylase 1 (PR:000003596) 470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
76 increased acetylcholine (CHEBI:15355) 10: Acetylcholine accumulation in synapses
75 decreased acetylcholinesterase activity (GO:0003990) acetylcholinesterase (PR:000003626) 12: Acetylcholinesterase (AchE) Inhibition
552 increased cell proliferation (GO:0008283) acinar cell (CL:0000622) 1062: Increased, Cellular proliferation / hyperplasia of acinar cells
1101 decreased dendritic spine morphogenesis (GO:0060997) actin cytoskeleton (GO:0015629) 2078: Loss of drebrin
1102 increased regulation of actin-dependent ATPase activity (GO:1904621) actin cytoskeleton (GO:0015629) 2078: Loss of drebrin
982 decreased impaired synaptic plasticity (MP:0001900) actin cytoskeleton of dendritic spine (GO:0098938) None
729 decreased activin receptor signaling pathway (GO:0032924) activin complex (GO:0048180) None
730 decreased activin receptor signaling pathway (GO:0032924) activin receptor complex (GO:0048179) None
943 increased acute-phase response (GO:0006953) Acute phase proteins (N/A)
174 increased gene expression (GO:0010467) acyl-CoA desaturase (PR:000014497)
366 increased Adenoma (MESH:D000236)
410 increased Carcinoma, Renal Cell (MESH:D002292) Adenoma (MESH:D000236) 713: Increase, Adenomas/carcinomas (renal tubular)
413 increased hepatocellular carcinoma (MESH:D006528) Adenoma (MESH:D000236) 719: Increase, hepatocellular adenomas and carcinomas
567 increased Pituitary adenoma (HP:0002893) Adenoma (MESH:D000236) 1082: Increased, adenomas (pituitary)
558 increased adenosquamous carcinoma (MESH:D018196) 1070: Increased, adenosquamous carcinomas of endometrium
1108 increased Endometrial carcinoma (HP:0012114) adenosquamous carcinoma (MESH:D018196) 1070: Increased, adenosquamous carcinomas of endometrium
486 decreased catalytic activity (GO:0003824) AKT kinase (PR:000029189) 973: KE5 : Decrease, AKT/eNOS activity
1060 decreased retinoic acid biosynthetic process (GO:0002138) all-trans-retinoic acid (CHEBI:15367) 1881: Decreased, all-trans retinoic acid (atRA) concentration
1113 decreased G-protein coupled receptor signaling pathway (GO:0007186) alpha-1A adrenergic receptor (PR:000001183) 2370: Agonism binding, α1-Adrenoreceptor
435 decreased signaling (GO:0023052) alpha-2A adrenergic receptor (PR:000001186) 849: Inhibition, Antgonism of NE receptor
1035 increased alpha-beta T cell receptor complex (GO:0042105) None
1036 increased gene conversion (GO:0035822) alpha-beta T cell receptor complex (GO:0042105) None