Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 351 to 375 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1052 occurrence gene conversion (GO:0035822) alpha-beta T cell receptor complex (GO:0042105) 2253: Gluten-reactive T cell receptors, generation
329 increased Amputation, Congenital (MESH:C565682) 591: Increased, amputations
1127 decreased regulation of DNA binding (GO:0051101) androgen (CHEBI:50113) 2393: Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced
1030 increased regulation of androgen receptor signaling pathway (GO:0060765) androgen receptor (PR:000004191) 2274: Androgen receptor activation, increased
1092 arrested androgen receptor signaling pathway (GO:0030521) androgen receptor (PR:000004191) None
1093 decreased androgen receptor signaling pathway (GO:0030521) androgen receptor (PR:000004191) None
1126 decreased protein import into nucleus, translocation (GO:0000060) androgen receptor (PR:000004191) 2393: Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced
96 decreased androgen receptor activity (GO:0004882) androgen receptor (PR:000004191)
99 decreased regulation of gene expression (GO:0010468) androgen receptor (PR:000004191) 286: Altered, Transcription of genes by the androgen receptor
107 increased androgen receptor activity (GO:0004882) androgen receptor (PR:000004191) 25: Agonism, Androgen receptor
592 decreased signaling (GO:0023052) androgen receptor (PR:000004191) 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
345 increased anesthesia (MESH:D000758) 634: N/A, sedation
813 increased regulation of peptidase activity (GO:0052547) angiotensin-converting enzyme (human) (PR:P12821) None
770 disrupted mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (PR:000003622) None
814 decreased angiotensin-converting enzyme 2 (PR:000003622) None
815 increased mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
816 increased carboxypeptidase activity (GO:0004180) angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
817 decreased protein localization to cell surface (GO:0034394) angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
818 increased angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
872 occurrence receptor binding (GO:0005102) angiotensin-converting enzyme 2 (PR:000003622) 1739: Binding to ACE2
812 increased mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (human) (PR:Q9BYF1) None
524 decreased swim bladder inflation (GO:0048798) anterior chamber swim bladder (UBERON:2001277) 1007: Reduced, Anterior swim bladder inflation
259 increased gene expression (GO:0010467) apolipoprotein B-100 (PR:000004145) 880: Increased, ApoB100
702 increased increased apoptosis (MP:0006042) apoptosis fated cell (CL:0000445) None
1084 increased apoptosis regulator BAX (PR:000002193) 2124: increased, Bax expression