Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 351 to 375 of 1147 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1110 decreased cellular response to oxidative stress (GO:0034599) 1869: Diminished protective oxidative stress response
714 increased cellular response to oxidative stress (GO:0034599) 1394: Induction, persistent proliferation/sustained proliferation
788 decreased cellular response to type I interferon (GO:0071357) type I interferon receptor complex (GO:0038197) None
708 abnormal chemical synaptic transmission (GO:0007268) synapse (GO:0045202) 758: Hippocampal Physiology, Altered
44 abnormal chemical synaptic transmission (GO:0007268) None
51 decreased chemical synaptic transmission (GO:0007268) 669: Reduction, Neuronal synaptic inhibition
195 increased chemokine activity (GO:0008009) Chemokine (FMA:241981) 151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
854 increased chemokine secretion (GO:0090195) Chemokine (FMA:241981) 1496: Increased, secretion of proinflammatory mediators
14 increased chitin biosynthetic process (GO:0006031) chitin (CHEBI:17029) 990: Increase, Incomplete ecdysis
751 decreased chitin synthase activity (GO:0004100) 1522: Inhibition, Chitin synthase 1
791 decreased chloride channel activity (GO:0005254) 1906: Cystic Fibrosis Transmembrane Regulator Function, Decreased
397 increased chloride channel activity (GO:0005254) glutamate-gated chloride channel (fruit fly) (PR:Q94900)
399 increased chloride transmembrane transport (GO:1902476) chloride (CHEBI:17996) 761: Increased, Chloride conductance
280 decreased cholesterol biosynthetic process (GO:0006695) cholesterol (CHEBI:16113)
1026 increased cholesterol biosynthetic process (GO:0006695) 2270: Increased, cholesterol synthesis enzymes
734 decreased cholesterol transport (GO:0030301) cholesterol (CHEBI:16113) 807: Decreased, cholesterol
735 decreased cholesterol transport (GO:0030301) cholesteryl ester (CHEBI:17002) 807: Decreased, cholesterol
863 increased chromosomal instability (MP:0008866) chromosome (GO:0005694)
862 increased chromosome breakage (GO:0031052) chromosome (GO:0005694)
371 abnormal chromosome movement towards spindle pole (GO:0051305) chromosome (GO:0005694) 752: Altered, Meiotic chromosome dynamics
357 abnormal chromosome segregation (GO:0007059) 696: Increased, Chromosome misseggregation
826 increased chronic inflammatory response (GO:0002544) 1868: Hyperinflammation
944 occurrence clathrin-dependent endocytosis (GO:0072583) None
894 increased Cleft palate (HP:0000175) 2042: Increase, Orofacial clefting
895 increased cleft upper lip (MP:0005170) 2042: Increase, Orofacial clefting